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WormBase Tree Display for Gene: WBGene00002018

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Name Class

WBGene00002018SMapS_parentSequenceY46H3A
IdentityVersion1
NameCGC_namehsp-16.41Person_evidenceWBPerson36
Sequence_nameY46H3A.2
Molecular_nameY46H3A.2
Y46H3A.2.1
CE22003
Other_namehsp-16
CELE_Y46H3A.2Accession_evidenceNDBBX284605
Public_namehsp-16.41
DB_infoDatabaseAceViewgene5C283
WormQTLgeneWBGene00002018
WormFluxgeneWBGene00002018
NDBlocus_tagCELE_Y46H3A.2
PanthergeneCAEEL|WormBase=WBGene00002018|UniProtKB=P06581
familyPTHR45640
NCBIgene178660
RefSeqproteinNM_182316.5
SwissProtUniProtAccP06581
UniProt_GCRPUniProtAccP06581
OMIMgene123580
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:26WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classhsp
Allele (21)
Strain (15)
In_clusterHSP16B
RNASeq_FPKM (74)
GO_annotation (11)
OrthologWBGene00027234Caenorhabditis briggsaeFrom_analysisOMA
WormBase-Compara
WBGene00052625Caenorhabditis remaneiFrom_analysisOMA
TreeFam
Inparanoid_8
WormBase-Compara
WBGene00038448Caenorhabditis briggsaeFrom_analysisOrthoMCL
OMA
Inparanoid_8
WormBase-Compara
WBGene00140961Caenorhabditis brenneriFrom_analysisOMA
TreeFam
Inparanoid_8
WormBase-Compara
WBGene00149500Caenorhabditis brenneriFrom_analysisOMA
TreeFam
Inparanoid_8
WormBase-Compara
WBGene00154236Caenorhabditis brenneriFrom_analysisOMA
TreeFam
Inparanoid_8
WormBase-Compara
WBGene00151214Caenorhabditis brenneriFrom_analysisOMA
TreeFam
Inparanoid_8
WormBase-Compara
WBGene00155603Caenorhabditis brenneriFrom_analysisOMA
TreeFam
Inparanoid_8
WormBase-Compara
WBGene00126654Caenorhabditis japonicaFrom_analysisTreeFam
Inparanoid_8
WormBase-Compara
WBGene00124823Caenorhabditis japonicaFrom_analysisTreeFam
Inparanoid_8
WormBase-Compara
WBGene00101797Pristionchus pacificusFrom_analysisOMA
Inparanoid_8
WBGene00101796Pristionchus pacificusFrom_analysisOMA
Inparanoid_8
WBGene00091037Pristionchus pacificusFrom_analysisOMA
Inparanoid_8
WBGene00027246Caenorhabditis briggsaeFrom_analysisOMA
WormBase-Compara
WBGene00073752Caenorhabditis remaneiFrom_analysisOMA
TreeFam
WBGene00068605Caenorhabditis remaneiFrom_analysisOMA
TreeFam
WBGene00073755Caenorhabditis remaneiFrom_analysisTreeFam
WBGene00068608Caenorhabditis remaneiFrom_analysisTreeFam
WBGene00226306Brugia malayiFrom_analysisWormBase-Compara
WBGene00226851Brugia malayiFrom_analysisWormBase-Compara
WBGene00236790Brugia malayiFrom_analysisWormBase-Compara
CBOVI.g12732Caenorhabditis bovisFrom_analysisWormBase-Compara
CBOVI.g12776Caenorhabditis bovisFrom_analysisWormBase-Compara
CBOVI.g12783Caenorhabditis bovisFrom_analysisWormBase-Compara
CBOVI.g12785Caenorhabditis bovisFrom_analysisWormBase-Compara
CSP21.g2043Caenorhabditis parvicaudaFrom_analysisWormBase-Compara
CSP26.g15082Caenorhabditis zanzibariFrom_analysisWormBase-Compara
CSP26.g5545Caenorhabditis zanzibariFrom_analysisWormBase-Compara
CSP26.g5547Caenorhabditis zanzibariFrom_analysisWormBase-Compara
CSP28.g4574Caenorhabditis panamensisFrom_analysisWormBase-Compara
CSP28.g5092Caenorhabditis panamensisFrom_analysisWormBase-Compara
CSP29.g17962Caenorhabditis beceiFrom_analysisWormBase-Compara
CSP29.g18638Caenorhabditis beceiFrom_analysisWormBase-Compara
CSP29.g5549Caenorhabditis beceiFrom_analysisWormBase-Compara
CSP32.g10286Caenorhabditis sulstoniFrom_analysisWormBase-Compara
CSP32.g14653Caenorhabditis sulstoniFrom_analysisWormBase-Compara
CSP32.g14657Caenorhabditis sulstoniFrom_analysisWormBase-Compara
CSP32.g14875Caenorhabditis sulstoniFrom_analysisWormBase-Compara
CSP32.g16154Caenorhabditis sulstoniFrom_analysisWormBase-Compara
CSP32.g6663Caenorhabditis sulstoniFrom_analysisWormBase-Compara
CSP39.g22417Caenorhabditis waitukubuliFrom_analysisWormBase-Compara
CSP39.g23489Caenorhabditis waitukubuliFrom_analysisWormBase-Compara
CSP39.g8365Caenorhabditis waitukubuliFrom_analysisWormBase-Compara
CSP39.g8373Caenorhabditis waitukubuliFrom_analysisWormBase-Compara
CSP40.g17873Caenorhabditis tribulationisFrom_analysisWormBase-Compara
CSP40.g21397Caenorhabditis tribulationisFrom_analysisWormBase-Compara
CSP40.g23637Caenorhabditis tribulationisFrom_analysisWormBase-Compara
Cnig_chr_V.g20090Caenorhabditis nigoniFrom_analysisWormBase-Compara
Cnig_chr_V.g20092Caenorhabditis nigoniFrom_analysisWormBase-Compara
Cnig_chr_V.g20529Caenorhabditis nigoniFrom_analysisWormBase-Compara
Cnig_chr_V.g20543Caenorhabditis nigoniFrom_analysisWormBase-Compara
Csp11.Scaffold575.g4426Caenorhabditis tropicalisFrom_analysisWormBase-Compara
Csp11.Scaffold630.g16839Caenorhabditis tropicalisFrom_analysisWormBase-Compara
Csp11.Scaffold630.g19838Caenorhabditis tropicalisFrom_analysisWormBase-Compara
Csp5_scaffold_00279.g8578Caenorhabditis sinicaFrom_analysisWormBase-Compara
Csp5_scaffold_01089.g18311Caenorhabditis sinicaFrom_analysisWormBase-Compara
Csp5_scaffold_06367.g36441Caenorhabditis sinicaFrom_analysisWormBase-Compara
FL83_24822Caenorhabditis latensFrom_analysisWormBase-Compara
GCK72_018404Caenorhabditis remaneiFrom_analysisWormBase-Compara
Sp34_10087200Caenorhabditis inopinataFrom_analysisWormBase-Compara
Sp34_50235600Caenorhabditis inopinataFrom_analysisWormBase-Compara
Sp34_50235800Caenorhabditis inopinataFrom_analysisWormBase-Compara
Sp34_50329000Caenorhabditis inopinataFrom_analysisWormBase-Compara
Sp34_50329200Caenorhabditis inopinataFrom_analysisWormBase-Compara
Sp34_50329800Caenorhabditis inopinataFrom_analysisWormBase-Compara
Sp34_50330100Caenorhabditis inopinataFrom_analysisWormBase-Compara
Sp34_50355400Caenorhabditis inopinataFrom_analysisWormBase-Compara
Sp34_50359400Caenorhabditis inopinataFrom_analysisWormBase-Compara
chrV_pilon.g13310Caenorhabditis elegansFrom_analysisWormBase-Compara
WBGene00236859Onchocerca volvulusFrom_analysisWormBase-Compara
WBGene00257141Strongyloides rattiFrom_analysisWormBase-Compara
WBGene00257259Strongyloides rattiFrom_analysisWormBase-Compara
WBGene00258086Strongyloides rattiFrom_analysisWormBase-Compara
WBGene00261172Strongyloides rattiFrom_analysisWormBase-Compara
WBGene00265225Strongyloides rattiFrom_analysisWormBase-Compara
WBGene00265337Strongyloides rattiFrom_analysisWormBase-Compara
WBGene00288111Trichuris murisFrom_analysisWormBase-Compara
WBGene00289300Trichuris murisFrom_analysisWormBase-Compara
WBGene00294628Trichuris murisFrom_analysisWormBase-Compara
WBGene00294630Trichuris murisFrom_analysisWormBase-Compara
WBGene00296278Trichuris murisFrom_analysisWormBase-Compara
WBGene00296279Trichuris murisFrom_analysisWormBase-Compara
FB:FBgn0011296Drosophila melanogasterFrom_analysisEnsEMBL-Compara
Inparanoid
Panther
FB:FBgn0001229Drosophila melanogasterFrom_analysisEnsEMBL-Compara
Inparanoid
Panther
FB:FBgn0001227Drosophila melanogasterFrom_analysisEnsEMBL-Compara
Inparanoid
Panther
FB:FBgn0001224Drosophila melanogasterFrom_analysisEnsEMBL-Compara
Hieranoid
Inparanoid
Panther
FB:FBgn0001223Drosophila melanogasterFrom_analysisEnsEMBL-Compara
Hieranoid
Inparanoid
Panther
ZFIN:ZDB-GENE-020508-1Danio rerioFrom_analysisEnsEMBL-Compara
OMA
Panther
HGNC:2388Homo sapiensFrom_analysisEnsEMBL-Compara
OMA
Panther
HGNC:CRYAA2Homo sapiensFrom_analysisEnsEMBL-Compara
OMA
Panther
RGD:2413Rattus norvegicusFrom_analysisEnsEMBL-Compara
Inparanoid
Panther
Paralog (17)
Structured_descriptionConcise_descriptionhsp-16.41 encodes a 16-kD heat shock protein (HSP) that is a member of the hsp16/hsp20/alphaB-crystallin (HSP16) family of heat shock proteins; an hsp-16.41 reporter fusion, expressed broadly but strongest in intestine and pharynx, is induced in response to heat shock or other environmental stresses; expression is detectable in somatic tissues in post-gastrulation embryos, all larval stages, and in adults; HSP-16.41 is likely to function as a passive ligand temporarily preventing unfolded proteins from aggregating.Paper_evidenceWBPaper00001187
WBPaper00001497
WBPaper00002665
WBPaper00004424
WBPaper00013029
WBPaper00013239
WBPaper00013280
Curator_confirmedWBPerson1843
Date_last_updated05 Nov 2004 00:00:00
Automated_descriptionPredicted to enable unfolded protein binding activity. Involved in defense response to Gram-negative bacterium and response to heat. Predicted to be located in cytoplasm and nucleus. Expressed in several structures, including alimentary muscle; coelomocyte; intestine; neurons; and ventral nerve cord. Human ortholog(s) of this gene implicated in cataract 9 multiple types. Is an ortholog of human CRYAA (crystallin alpha A).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoPotential_modelDOID:0110266Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:2388)
Disease_relevanceC. elegans is an effective model system to study heat-related pathologies like heat stroke; in elegans, the heat-shock transcription factor, after activation, induces the expression of other small heat shock proteins (sHSP); HSP-16.1 has a protective effect against heat-induced necrosis; HSP-16.1 localizes to the golgi and functions together with the PMR-1/PMR1 Ca2+ and Mn2+ transporting ATPase, and NUCB-1/Nucleobindin1, a golgi-located calcium-buffering protein, to maintain calcium homeostasis, under heat stroke; overexpresiion of pmr-1/PMR1 is sufficient to promote survival after heat stroke, bypassing both HSF-1 and HSP-16.1, indicating that PMR-1/PMR1 functions downstream of both these genes; also, the sHSPs, HSP-16.1, HSP-16.41 and DNJ-19 are required for an acquired tolerance to heat stroke.Homo sapiensPaper_evidenceWBPaper00041564
Curator_confirmedWBPerson324
Date_last_updated29 May 2013 00:00:00
Molecular_infoCorresponding_CDSY46H3A.2
Corresponding_transcriptY46H3A.2.1
Other_sequence (61)
Associated_featureWBsf646680
WBsf646681
WBsf919559
WBsf919560
WBsf919561
WBsf919562
WBsf231437
WBsf231438
WBsf231439
Experimental_infoRNAi_resultWBRNAi00027603Inferred_automaticallyRNAi_primary
WBRNAi00056699Inferred_automaticallyRNAi_primary
WBRNAi00106383Inferred_automaticallyRNAi_primary
WBRNAi00076794Inferred_automaticallyRNAi_primary
WBRNAi00070131Inferred_automaticallyRNAi_primary
WBRNAi00020673Inferred_automaticallyRNAi_primary
Expr_pattern (11)
Drives_construct (176)
Construct_productWBCnstr00010254
WBCnstr00010255
WBCnstr00017025
WBCnstr00036518
WBCnstr00042209
AntibodyWBAntibody00000051
WBAntibody00001859
Microarray_results (17)
Expression_cluster (413)
Interaction (45)
Map_infoMapVPosition-17.4232Error0.07866
PositivePositive_cloneY46H3AInferred_automaticallyFrom sequence, transcript, pseudogene data
Mapping_dataMulti_point4418
Pseudo_map_position
Reference (69)
RemarkMap position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene