WormBase Tree Display for Gene: WBGene00001746
expand all nodes | collapse all nodes | view schema
| WBGene00001746 | Evidence | Person_evidence | WBPerson1698 | ||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | Y18D10A | ||||||
| Identity | Version | 1 | |||||||
| Name | CGC_name | gsk-3 | Person_evidence | WBPerson75 | |||||
| Sequence_name | Y18D10A.5 | ||||||||
| Molecular_name | Y18D10A.5 | ||||||||
| Y18D10A.5.1 | |||||||||
| CE21401 | |||||||||
| Other_name | sgg-1 | ||||||||
| Y18D10A.f | Curator_confirmed | WBPerson1983 | |||||||
| Remark | Old cosmid naming mapped via unique overlapping PCR_product on CDSs | ||||||||
| CELE_Y18D10A.5 | Accession_evidence | NDB | BX284601 | ||||||
| Public_name | gsk-3 | ||||||||
| DB_info | Database (13) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:25 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | gsk | ||||||||
| Allele (132) | |||||||||
| Possibly_affected_by | WBVar02153198 | ||||||||
| Strain | WBStrain00040436 | ||||||||
| WBStrain00000267 | |||||||||
| WBStrain00024318 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (41) | |||||||||
| Ortholog (48) | |||||||||
| Paralog | WBGene00010991 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WormBase-Compara | |||||||||
| WBGene00008095 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| Structured_description | Concise_description | gsk-3 encodes the C. elegans glycogen synthase kinase ortholog; during embryonic development, GSK-3 functions in the Wnt signaling pathway that restricts specification of mesendodermal tissue to the appropriate blastomere; GSK-3 also functions in a Wnt pathway that regulates anteroposterior axon guidance; GSK-3 plays a role in regulating the oocyte-to-embryo transition, by phosphorylating and negatively regulating the OMA-1 zinc finger protein, and in regulation of the oxidative stress response pathway by phosphorylating SKN-1, thereby excluding it from intestinal nuclei; GSK-3, along with MOM-5/Frizzled and APR-1/APC is also required for distal tip cell migration in the gonad and for the engulfment of apoptotic cells, indicating that the Wnt pathway signals to CED-10/Rac to regulate cytoskeletal rearrangement during different cellular processes; GSK-3 can be phosphorylated by murine ERK2 in vitro, suggesting that it is a substrate for the RTK-RAS-ERK pathway in vivo; consistent with this, GSK-3 phosphorylation is absent in mpk-1 mutant animals. | Paper_evidence | WBPaper00004636 | |||||
| WBPaper00026924 | |||||||||
| WBPaper00027607 | |||||||||
| WBPaper00032955 | |||||||||
| WBPaper00035874 | |||||||||
| WBPaper00032961 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson324 | |||||||||
| Date_last_updated | 23 Jan 2012 00:00:00 | ||||||||
| Automated_description | Enables protein serine/threonine kinase activity. Involved in several processes, including engulfment of apoptotic cell; left/right axis specification; and regulation of cellular component organization. Predicted to be located in cytosol and nucleus. Expressed in distal tip cell; seam cell; and sperm. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; bipolar disorder; carcinoma (multiple); and degenerative disc disease. Is an ortholog of human GSK3A (glycogen synthase kinase 3 alpha) and GSK3B (glycogen synthase kinase 3 beta). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0050866 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:4617) | ||||
| DOID:10652 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:4617) | ||||||
| DOID:3312 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:4617) | ||||||
| DOID:2871 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:4617) | ||||||
| DOID:0050861 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:4617) | ||||||
| DOID:332 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:4616,HGNC:4617) | ||||||
| DOID:90 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:4617) | ||||||
| DOID:5419 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:4617) | ||||||
| Molecular_info | Corresponding_CDS | Y18D10A.5 | |||||||
| Corresponding_transcript | Y18D10A.5.1 | ||||||||
| Other_sequence (86) | |||||||||
| Associated_feature | WBsf981118 | ||||||||
| WBsf1010971 | |||||||||
| WBsf218641 | |||||||||
| WBsf218642 | |||||||||
| Experimental_info | RNAi_result (113) | ||||||||
| Expr_pattern | Expr13709 | ||||||||
| Expr15114 | |||||||||
| Expr1012893 | |||||||||
| Expr1031039 | |||||||||
| Expr1159129 | |||||||||
| Expr2012283 | |||||||||
| Expr2030519 | |||||||||
| Construct_product | WBCnstr00000615 | ||||||||
| Antibody | WBAntibody00001673 | ||||||||
| Microarray_results (21) | |||||||||
| Expression_cluster (92) | |||||||||
| Interaction (309) | |||||||||
| Anatomy_function | WBbtf0749 | ||||||||
| WBProcess | WBbiopr:00000073 | ||||||||
| Map_info | Map | I | Position | 14.0947 | Error | 0.019406 | |||
| Positive | Positive_clone | Y18D10A | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Mapping_data | Multi_point | 4534 | |||||||
| 4967 | |||||||||
| Pseudo_map_position | |||||||||
| Reference (98) | |||||||||
| Remark | gsk-3 is the main name for sgg-1 | ||||||||
| Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
| Method | Gene |
