WormBase Tree Display for Gene: WBGene00001746

WBGene00001746 Evidence: Person_evidence: WBPerson1698
  SMap: S_parent: Sequence: Y18D10A
  Identity: Version: 1
    Name: CGC_name: gsk-3 Person_evidence: WBPerson75
      Sequence_name: Y18D10A.5
      Molecular_name: Y18D10A.5
        Y18D10A.5.1
        CE21401
      Other_name: sgg-1
        Y18D10A.f Curator_confirmed: WBPerson1983
          Remark: Old cosmid naming mapped via unique overlapping PCR_product on CDSs
        CELE_Y18D10A.5 Accession_evidence: NDB BX284601
      Public_name: gsk-3
    DB_info: Database (13)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:25 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: gsk
    Allele (132)
    Possibly_affected_by: WBVar02153198
    Strain: WBStrain00040436
      WBStrain00000267
      WBStrain00024318
    RNASeq_FPKM (74)
    GO_annotation (41)
    Ortholog (48)
    Paralog: WBGene00010991 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00008095 Caenorhabditis elegans From_analysis: Panther
    Structured_description: Concise_description: gsk-3 encodes the C. elegans glycogen synthase kinase ortholog; during embryonic development, GSK-3 functions in the Wnt signaling pathway that restricts specification of mesendodermal tissue to the appropriate blastomere; GSK-3 also functions in a Wnt pathway that regulates anteroposterior axon guidance; GSK-3 plays a role in regulating the oocyte-to-embryo transition, by phosphorylating and negatively regulating the OMA-1 zinc finger protein, and in regulation of the oxidative stress response pathway by phosphorylating SKN-1, thereby excluding it from intestinal nuclei; GSK-3, along with MOM-5/Frizzled and APR-1/APC is also required for distal tip cell migration in the gonad and for the engulfment of apoptotic cells, indicating that the Wnt pathway signals to CED-10/Rac to regulate cytoskeletal rearrangement during different cellular processes; GSK-3 can be phosphorylated by murine ERK2 in vitro, suggesting that it is a substrate for the RTK-RAS-ERK pathway in vivo; consistent with this, GSK-3 phosphorylation is absent in mpk-1 mutant animals. Paper_evidence: WBPaper00004636
            WBPaper00026924
            WBPaper00027607
            WBPaper00032955
            WBPaper00035874
            WBPaper00032961
          Curator_confirmed: WBPerson1843
            WBPerson324
          Date_last_updated: 23 Jan 2012 00:00:00
      Automated_description: Enables protein serine/threonine kinase activity. Involved in several processes, including engulfment of apoptotic cell; left/right axis specification; and regulation of cellular component organization. Predicted to be located in cytosol and nucleus. Expressed in distal tip cell; seam cell; and sperm. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; bipolar disorder; carcinoma (multiple); and degenerative disc disease. Is an ortholog of human GSK3A (glycogen synthase kinase 3 alpha) and GSK3B (glycogen synthase kinase 3 beta). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:0050866 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4617)
      DOID:10652 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4617)
      DOID:3312 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4617)
      DOID:2871 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4617)
      DOID:0050861 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4617)
      DOID:332 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4616,HGNC:4617)
      DOID:90 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4617)
      DOID:5419 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4617)
  Molecular_info: Corresponding_CDS: Y18D10A.5
    Corresponding_transcript: Y18D10A.5.1
    Other_sequence (86)
    Associated_feature: WBsf981118
      WBsf1010971
      WBsf218641
      WBsf218642
  Experimental_info: RNAi_result (113)
    Expr_pattern: Expr13709
      Expr15114
      Expr1012893
      Expr1031039
      Expr1159129
      Expr2012283
      Expr2030519
    Construct_product: WBCnstr00000615
    Antibody: WBAntibody00001673
    Microarray_results (21)
    Expression_cluster (92)
    Interaction: WBInteraction000005202
      WBInteraction000006081
      WBInteraction000006242
      WBInteraction000006396
      WBInteraction000006464
      WBInteraction000006862
      WBInteraction000006906
      WBInteraction000006929
      WBInteraction000007138
      WBInteraction000007200
      WBInteraction000007237
      WBInteraction000007342
      WBInteraction000009113
      WBInteraction000028460
      WBInteraction000028461
      WBInteraction000029059
      WBInteraction000029431
      WBInteraction000030800
      WBInteraction000030801
      WBInteraction000030802
      WBInteraction000030803
      WBInteraction000032584
      WBInteraction000032703
      WBInteraction000032725
      WBInteraction000032733
      WBInteraction000032773
      WBInteraction000032881
      WBInteraction000032971
      WBInteraction000032998
      WBInteraction000033003
      WBInteraction000033010
      WBInteraction000033041
      WBInteraction000033042
      WBInteraction000033117
      WBInteraction000033133
      WBInteraction000033257
      WBInteraction000033305
      WBInteraction000034112
      WBInteraction000036861
      WBInteraction000037148
      WBInteraction000037434
      WBInteraction000038213
      WBInteraction000038681
      WBInteraction000038838
      WBInteraction000041895
      WBInteraction000042464
      WBInteraction000042705
      WBInteraction000042724
      WBInteraction000043064
      WBInteraction000043399
      WBInteraction000043761
      WBInteraction000043762
      WBInteraction000043981
      WBInteraction000044014
      WBInteraction000046100
      WBInteraction000047206
      WBInteraction000048844
      WBInteraction000049019
      WBInteraction000049020
      WBInteraction000049021
      WBInteraction000049022
      WBInteraction000049038
      WBInteraction000049039
      WBInteraction000049040
      WBInteraction000049041
      WBInteraction000049042
      WBInteraction000049043
      WBInteraction000049135
      WBInteraction000049261
      WBInteraction000049953
      WBInteraction000049954
      WBInteraction000050047
      WBInteraction000050496
      WBInteraction000050673
      WBInteraction000110603
      WBInteraction000110665
      WBInteraction000110714
      WBInteraction000110734
      WBInteraction000110928
      WBInteraction000112591
      WBInteraction000112639
      WBInteraction000113007
      WBInteraction000113616
      WBInteraction000114159
      WBInteraction000114441
      WBInteraction000114594
      WBInteraction000115195
      WBInteraction000115213
      WBInteraction000115214
      WBInteraction000115486
      WBInteraction000116283
      WBInteraction000117496
      WBInteraction000117569
      WBInteraction000119669
      WBInteraction000120125
      WBInteraction000121580
      WBInteraction000126777
      WBInteraction000127088
      WBInteraction000127450
      WBInteraction000133150
      WBInteraction000133721
      WBInteraction000134260
      WBInteraction000140495
      WBInteraction000143054
      WBInteraction000144539
      WBInteraction000147204
      WBInteraction000147905
      WBInteraction000151879
      WBInteraction000157336
      WBInteraction000157337
      WBInteraction000159780
      WBInteraction000162439
      WBInteraction000162955
      WBInteraction000165848
      WBInteraction000166084
      WBInteraction000167072
      WBInteraction000168846
      WBInteraction000171964
      WBInteraction000172278
      WBInteraction000172880
      WBInteraction000173021
      WBInteraction000173198
      WBInteraction000173199
      WBInteraction000173200
      WBInteraction000173201
      WBInteraction000173403
      WBInteraction000173741
      WBInteraction000173767
      WBInteraction000174082
      WBInteraction000174122
      WBInteraction000174229
      WBInteraction000174237
      WBInteraction000174323
      WBInteraction000174415
      WBInteraction000174513
      WBInteraction000175013
      WBInteraction000181372
      WBInteraction000183131
      WBInteraction000189958
      WBInteraction000194410
      WBInteraction000195171
      WBInteraction000196725
      WBInteraction000197953
      WBInteraction000203514
      WBInteraction000226239
      WBInteraction000228090
      WBInteraction000232572
      WBInteraction000236011
      WBInteraction000240412
      WBInteraction000242122
      WBInteraction000246448
      WBInteraction000257161
      WBInteraction000262600
      WBInteraction000264846
      WBInteraction000266385
      WBInteraction000275977
      WBInteraction000277379
      WBInteraction000284850
      WBInteraction000288932
      WBInteraction000292001
      WBInteraction000298353
      WBInteraction000300223
      WBInteraction000307056
      WBInteraction000307320
      WBInteraction000310274
      WBInteraction000313391
      WBInteraction000317974
      WBInteraction000319346
      WBInteraction000326316
      WBInteraction000329759
      WBInteraction000335226
      WBInteraction000338907
      WBInteraction000339224
      WBInteraction000341442
      WBInteraction000342031
      WBInteraction000344368
      WBInteraction000345533
      WBInteraction000347051
      WBInteraction000347870
      WBInteraction000348010
      WBInteraction000348031
      WBInteraction000348994
      WBInteraction000352759
      WBInteraction000357927
      WBInteraction000360773
      WBInteraction000361662
      WBInteraction000361663
      WBInteraction000361688
      WBInteraction000361689
      WBInteraction000363650
      WBInteraction000363686
      WBInteraction000369308
      WBInteraction000369310
      WBInteraction000371903
      WBInteraction000372904
      WBInteraction000376850
      WBInteraction000380989
      WBInteraction000384394
      WBInteraction000384548
      WBInteraction000384755
      WBInteraction000384934
      WBInteraction000385085
      WBInteraction000390805
      WBInteraction000402848
      WBInteraction000413146
      WBInteraction000413512
      WBInteraction000413513
      WBInteraction000417735
      WBInteraction000419330
      WBInteraction000422538
      WBInteraction000430419
      WBInteraction000433153
      WBInteraction000433409
      WBInteraction000435897
      WBInteraction000460781
      WBInteraction000469830
      WBInteraction000471750
      WBInteraction000473172
      WBInteraction000473229
      WBInteraction000500029
      WBInteraction000500030
      WBInteraction000500031
      WBInteraction000500032
      WBInteraction000502069
      WBInteraction000502193
      WBInteraction000502249
      WBInteraction000502250
      WBInteraction000502267
      WBInteraction000506322
      WBInteraction000506323
      WBInteraction000506324
      WBInteraction000506325
      WBInteraction000506326
      WBInteraction000506327
      WBInteraction000506328
      WBInteraction000506329
      WBInteraction000506330
      WBInteraction000506331
      WBInteraction000506332
      WBInteraction000506333
      WBInteraction000506334
      WBInteraction000506335
      WBInteraction000506336
      WBInteraction000506337
      WBInteraction000506338
      WBInteraction000506339
      WBInteraction000506340
      WBInteraction000506341
      WBInteraction000506342
      WBInteraction000506343
      WBInteraction000506344
      WBInteraction000506345
      WBInteraction000506346
      WBInteraction000506347
      WBInteraction000506348
      WBInteraction000506349
      WBInteraction000506350
      WBInteraction000506351
      WBInteraction000506352
      WBInteraction000506353
      WBInteraction000506354
      WBInteraction000506355
      WBInteraction000506356
      WBInteraction000506357
      WBInteraction000506358
      WBInteraction000506359
      WBInteraction000506360
      WBInteraction000506361
      WBInteraction000506362
      WBInteraction000506363
      WBInteraction000521618
      WBInteraction000521620
      WBInteraction000522280
      WBInteraction000522311
      WBInteraction000522318
      WBInteraction000522319
      WBInteraction000522921
      WBInteraction000522922
      WBInteraction000538739
      WBInteraction000538740
      WBInteraction000539217
      WBInteraction000539353
      WBInteraction000540388
      WBInteraction000540622
      WBInteraction000540849
      WBInteraction000541759
      WBInteraction000542287
      WBInteraction000543755
      WBInteraction000543999
      WBInteraction000547202
      WBInteraction000548296
      WBInteraction000548371
      WBInteraction000548775
      WBInteraction000551642
      WBInteraction000554853
      WBInteraction000554854
      WBInteraction000556304
      WBInteraction000556628
      WBInteraction000557826
      WBInteraction000558546
      WBInteraction000559568
      WBInteraction000564879
      WBInteraction000571854
      WBInteraction000573428
      WBInteraction000579434
      WBInteraction000580023
      WBInteraction000581886
      WBInteraction000582702
      WBInteraction000582974
    Anatomy_function: WBbtf0749
    WBProcess: WBbiopr:00000073
  Map_info: Map: I Position: 14.0947 Error: 0.019406
    Positive: Positive_clone: Y18D10A Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4534
        4967
    Pseudo_map_position
  Reference (98)
  Remark: gsk-3 is the main name for sgg-1
    Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene