WormBase Tree Display for Gene: WBGene00001689
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| WBGene00001689 | Evidence | CGC_data_submission | |||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | C38C10 | ||||||
| Identity | Version | 1 | |||||||
| Name | CGC_name | gpr-2 | Person_evidence | WBPerson732 | |||||
| Sequence_name | C38C10.4 | ||||||||
| Molecular_name | C38C10.4 | ||||||||
| C38C10.4.1 | |||||||||
| CE00107 | |||||||||
| Other_name | ags-3.3 | ||||||||
| lap-1/ags-3.3 | Paper_evidence | WBPaper00010166 | |||||||
| CELE_C38C10.4 | Accession_evidence | NDB | BX284603 | ||||||
| Public_name | gpr-2 | ||||||||
| DB_info | Database | AceView | gene | 3K482 | |||||
| WormQTL | gene | WBGene00001689 | |||||||
| WormFlux | gene | WBGene00001689 | |||||||
| NDB | locus_tag | CELE_C38C10.4 | |||||||
| NCBI | gene | 176318 | |||||||
| RefSeq | protein | NM_066665.8 | |||||||
| SwissProt | UniProtAcc | Q03569 | |||||||
| TREEFAM | TREEFAM_ID | TF318159 | |||||||
| UniProt_GCRP | UniProtAcc | Q03569 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:25 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | gpr | ||||||||
| Allele (23) | |||||||||
| Strain | WBStrain00031852 | ||||||||
| WBStrain00034750 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (11) | |||||||||
| Contained_in_operon | CEOP3576 | ||||||||
| Ortholog (20) | |||||||||
| Paralog | WBGene00001688 | Caenorhabditis elegans | From_analysis | TreeFam | |||||
| Inparanoid_8 | |||||||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | gpr-2 encodes a protein containing a GPR (G Protein Regulator)/GoLoco motif characteristic of guanine nucleotide exchange factors specific for G-alpha GTPases; GPR-2 appears to function redundantly during early embryogenesis and germ-line development to regulate chromosome and spindle movements during cell division; GPR-2 likely acts as a positive regulator of G protein signaling and specifically, may regulate GOA-1 signaling in the embryo; GPR-2 forms a protein complex with the nearly identical GPR-1 and with LIN-5, a coiled-coil protein that is required for proper localization of GPR-2 to the cell cortex and spindle asters of the early embryo; in addition, proper GPR-2/GPR-1/LIN-5 localization between the P2 and EMS blastomeres at the four-cell stage, which may contribute to spindle positioning in EMS, requires the MES-1/SRC-1 tyrosine kinase signaling pathway; GPR-2 is believed to act downstream of, or in parallel to, PAR-3, a PDZ domain-containing protein, in mitotic spindle positioning in the early embryo. | Paper_evidence | WBPaper00005405 | |||||
| WBPaper00005878 | |||||||||
| WBPaper00017879 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
| Automated_description | Enables GDP-dissociation inhibitor activity. Predicted to be involved in cell division. Located in aster and cell cortex. Expressed in P lineage cell. | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | C38C10.4 | |||||||
| Corresponding_transcript | C38C10.4.1 | ||||||||
| Other_sequence | CBC07136_1 | ||||||||
| Associated_feature | WBsf655471 | ||||||||
| WBsf227280 | |||||||||
| WBsf227281 | |||||||||
| Experimental_info | RNAi_result (55) | ||||||||
| Expr_pattern | Expr2564 | ||||||||
| Expr10765 | |||||||||
| Expr1013915 | |||||||||
| Expr1031008 | |||||||||
| Expr1146135 | |||||||||
| Expr1200200 | |||||||||
| Expr2012214 | |||||||||
| Expr2030450 | |||||||||
| Drives_construct | WBCnstr00036767 | ||||||||
| Construct_product | WBCnstr00010004 | ||||||||
| WBCnstr00019267 | |||||||||
| WBCnstr00036767 | |||||||||
| Antibody | WBAntibody00000624 | ||||||||
| WBAntibody00000631 | |||||||||
| WBAntibody00000632 | |||||||||
| WBAntibody00000648 | |||||||||
| WBAntibody00000701 | |||||||||
| WBAntibody00000783 | |||||||||
| WBAntibody00000790 | |||||||||
| WBAntibody00001312 | |||||||||
| WBAntibody00001392 | |||||||||
| Microarray_results (11) | |||||||||
| Expression_cluster (126) | |||||||||
| Interaction (58) | |||||||||
| WBProcess | WBbiopr:00000017 | ||||||||
| Map_info | Map | III | Position | 0.469922 | Error | 0.005225 | |||
| Positive | Positive_clone | C38C10 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference (64) | |||||||||
| Remark | Sequence connection from [Ahringer JA] | ||||||||
| Gene renamed from ags-3.3 to gpr-2 following advice from [Hodgkin J], [020808 krb] | |||||||||
| Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
| Method | Gene |
