| WBGene00001688 | Evidence | CGC_data_submission |
|---|
| SMap | S_parent | Sequence | F22B7 |
| Identity | Version | 1 |
| | Name | CGC_name | gpr-1 | Person_evidence | WBPerson732 |
| | | Sequence_name | F22B7.13 |
| | | Molecular_name | F22B7.13 |
| | | | F22B7.13.1 |
| | | | CE24910 |
| | | Other_name | ags-3.2 |
| | | | lap-2/ags-3.2 | Paper_evidence | WBPaper00010166 |
| | | | CELE_F22B7.13 | Accession_evidence | NDB | BX284603 |
| | | Public_name | gpr-1 |
| | DB_info | Database | AceView | gene | 3J719 |
| | | | WormQTL | gene | WBGene00001688 |
| | | | WormFlux | gene | WBGene00001688 |
| | | | NDB | locus_tag | CELE_F22B7.13 |
| | | | NCBI | gene | 176210 |
| | | | RefSeq | protein | NM_066499.5 |
| | | | SwissProt | UniProtAcc | Q95QJ7 |
| | | | TREEFAM | TREEFAM_ID | TF318159 |
| | | | UniProt_GCRP | UniProtAcc | Q95QJ7 |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:25 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | gpr |
| | Allele (26) |
| | Strain | WBStrain00036782 |
| | | WBStrain00007343 |
| | RNASeq_FPKM (74) |
| | GO_annotation (15) |
| | Contained_in_operon | CEOP3875 |
| | Ortholog (20) |
| | Paralog | WBGene00001689 | Caenorhabditis elegans | From_analysis | TreeFam |
| | | | | | Inparanoid_8 |
| | | | | | WormBase-Compara |
| | Structured_description | Concise_description | gpr-1 encodes an extremely similar (97% identity) paralog of GPR-2; GPR-1(and GPR-2) proteins have two N-terminal tetratricopeptide-like motifs anda C-terminal GoLoco/GPR (G protein regulatory) motif, the latter of whichhas also been found in mammalian AGS3 and Drosophila Pins; GPR-1 isrequired for normally asymmetrical cleavage of one-cell embryos; GPR-1 andGPR-2 form a high molecular weight (~700 kDa) complex that includes LIN-5;GPR-1 binds GDP-bound GOA-1 via a GoLoco/GPR motif, and depends on RIC-8for this binding; GPR-1/2, GOA-1, and LIN-5 colocalize at the cortex ofearly embryos; cortical enrichment of GPR-1 requires LIN-5, PAR-2, PAR-3,and LET-99; the asymmetric distribution of GPR-1/2 and LET-99 in EMS cellsis dependent on MES-1/SRC-1 signaling; GPR-1/2 is co-immunoprecipitatedwith RIC-8 and GPA-16. | Paper_evidence | WBPaper00005878 |
| | | | | | WBPaper00005918 |
| | | | | | WBPaper00005945 |
| | | | | | WBPaper00006289 |
| | | | | | WBPaper00024244 |
| | | | | | WBPaper00024481 |
| | | | | | WBPaper00026807 |
| | | | | Curator_confirmed | WBPerson567 |
| | | | | Date_last_updated | 06 Sep 2006 00:00:00 |
| | | Automated_description | Enables G-protein alpha-subunit binding activity and GDP-dissociation inhibitor activity. Predicted to be involved in cell division. Located in aster and cell cortex. Expressed in P lineage cell. | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Molecular_info | Corresponding_CDS | F22B7.13 |
| | Corresponding_transcript | F22B7.13.1 |
| | Other_sequence | CJC06602_1 |
| | | CBC04217_1 |
| | Associated_feature | WBsf225448 |
| Experimental_info | RNAi_result (55) |
| | Expr_pattern | Expr2564 |
| | | Expr10765 |
| | | Expr1031007 |
| | | Expr1149216 |
| | | Expr2012213 |
| | | Expr2030449 |
| | Drives_construct | WBCnstr00036768 |
| | Construct_product | WBCnstr00007804 |
| | | WBCnstr00007805 |
| | | WBCnstr00010003 |
| | | WBCnstr00036768 |
| | Antibody | WBAntibody00000624 |
| | | WBAntibody00000631 |
| | | WBAntibody00000632 |
| | | WBAntibody00000783 |
| | | WBAntibody00001312 |
| | | WBAntibody00001392 |
| | Microarray_results (17) |
| | Expression_cluster | WBPaper00031040:TGF-beta_adult_downregulated |
| | | WBPaper00037950:A-class-motor-neurons_L2-larva_expressed |
| | | WBPaper00037950:all-neurons_L2-larva_expressed |
| | | WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed |
| | | WBPaper00037950:coelomocytes_L2-larva_expressed |
| | | WBPaper00037950:intestine_L2-larva_expressed |
| | | WBPaper00038168:lin-35_upregulated |
| | | WBPaper00044501:gld-1_let-7_regulated |
| | | WBPaper00044656:tatn-1(qd182)_downregulated |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00044760:germline_specific |
| | | WBPaper00045521:Gender_Neutral |
| | | WBPaper00045571:germline-ablation_downregulated |
| | | WBPaper00045774:clk-1_downregulated |
| | | WBPaper00046509:lin-35(n745)_upregulated |
| | | WBPaper00046805:csr-1(RNAi)_upregulated_Set1 |
| | | WBPaper00048690:hermaphrodite-Z1-Z4-daughter_enriched |
| | | WBPaper00048690:male-Z1-Z4-daughter_enriched |
| | | WBPaper00048971:daf-16(mgDf50)_downregulated_L1 |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049498:npr-1(ur89)_regulated_8 |
| | | WBPaper00049545:jmjd-3.1(+)_downregulated |
| | | WBPaper00050193:cec-4(ok3124)_downregulated_L1 |
| | | WBPaper00050193:met-2(n4256)set-25(n5021)_downregulated_L1 |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C |
| | | WBPaper00050488:N2_vs_mir-34(OverExpression)_regulated_dauer_20C |
| | | WBPaper00050522:mafr-1(tm6082)_downregulated |
| | | WBPaper00050726:OsmoticStress_regulated_Food |
| | | WBPaper00050726:OsmoticStress_regulated_NoFood |
| | | WBPaper00050801:DAF-16_dauer_regulome |
| | | WBPaper00050859:downregulated_P-granule(-)GFP(+)_vs_control_day2-adult |
| | | WBPaper00051039:germline_enriched |
| | | WBPaper00053184:sma-2(rax5)_downregulated |
| | | WBPaper00053184:sma-4(rax3)_downregulated |
| | | WBPaper00053289:DREAM-target |
| | | WBPaper00053302:stavudine_24h_regulated |
| | | WBPaper00053302:zidovudine_72h_regulated |
| | | WBPaper00053388:dauer_regulated_Cluster3 |
| | | WBPaper00053810:nuo-6(qm200)_downregulated |
| | | WBPaper00055334:DLC-1_interacting |
| | | WBPaper00055354:eat-2(ad1116)_downregulated |
| | | WBPaper00055354:Rifampicin-Psora_downregulated |
| | | WBPaper00055482:pmt-2(RNAi)_downregulated |
| | | WBPaper00055648:germline_expressed |
| | | WBPaper00055862:antimycin_damt-1(gk961032)_regulated |
| | | WBPaper00055971:nhl-2(ok818)_20C_upregulated |
| | | WBPaper00055971:nhl-2(ok818)_25C_upregulated |
| | | WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047) |
| | | WBPaper00056443:sek-1(km4)_downregulated |
| | | WBPaper00057041:unc-70(cas983)_upregulated |
| | | WBPaper00057288:iff-1(RNAi)_downregulated_transcript |
| | | WBPaper00058691:cfp-1(tm6369)_downregulated |
| | | WBPaper00058691:sin-3(tm1276)_downregulated |
| | | WBPaper00058725:sftb-1(cer6)_upregulated |
| | | WBPaper00059598:HeatShock_downregulated |
| | | WBPaper00059605:MUT-16_interacting |
| | | WBPaper00059664:srbc-48(ac23)_downregulated |
| | | WBPaper00060014:set-2(tm1630)_upregulated |
| | | WBPaper00060661:sensory-neuron_depleted |
| | | WBPaper00060811:L1_vs_adult_downregulated_neural |
| | | WBPaper00061007:S.aquatilis_downregulated |
| | | WBPaper00061340:Neuroblast_IL1_IL2 |
| | | WBPaper00061466:nath-10(icb99)_downregulated |
| | | WBPaper00061527:F54E7.8-orc-5_6376 |
| | | WBPaper00061530:nhr-49(e2144)_downregulated |
| | | WBPaper00061699:daf-18(ok480)_upregulated |
| | | WBPaper00062056:dpl-1(n2994)_upregulated |
| | | WBPaper00062056:efl-1(se1)_upregulated |
| | | WBPaper00062056:lin-35(n745)_upregulated |
| | | WBPaper00062056:lin-36(n766)_upregulated |
| | | WBPaper00062056:lin-36(we31)_upregulated |
| | | WBPaper00062056:lin-36(we36)_upregulated |
| | | WBPaper00062056:lin-37(n758)_upregulated |
| | | WBPaper00062159:hda-2(ok1479)_downregulated |
| | | WBPaper00062325:muscle_depleted_coding-RNA |
| | | WBPaper00064088:Day-1-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141) |
| | | WBPaper00064088:Day-1-adult_vs_L4_downregulated_glp-1(e2141) |
| | | WBPaper00064088:Day-1-adult_vs_L4_upregulated_fem-3(q20) |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141) |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_glp-1(e2141) |
| | | WBPaper00064088:Day-3-adult_vs_L4_upregulated_fem-3(q20) |
| | | WBPaper00064403:Heat-killed-E.Coli_upregulated |
| | | WBPaper00064716:paraquat_upregulated |
| | | WBPaper00064735:bet-1(uth41)_vs_N2_upregulated |
| | | WBPaper00065096:Day10_vs_Day1_upregulated |
| | | WBPaper00065149:lin-52(n771)_upregulated |
| | | WBPaper00065841:76_0 |
| | | WBPaper00065975:P-body_vs_oocyte_depleted |
| | | WBPaper00065993:glp-1(e2141)_downregulated |
| | | WBPaper00066146:germline-inx-14(RNAi)_downregulated_PA14 |
| | | cgc4489_group_6 |
| | | WBPaper00025032:cluster_7 |
| | | WBPaper00025141:N2_Expressed_Genes |
| | | WBPaper00028564:CeMM_vs_NGM_downregulated |
| | | WBPaper00031003:24hr_muscle_depleted |
| | | WBPaper00031003:total_muscle_depleted |
| | | WBPaper00031532:Larva_Pan_Neuronal_Depleted |
| | | WBPaper00032165:differentially_expressed_with_age_medoid_7 |
| | | WBPaper00032948:FedUp |
| | | WBPaper00035905:FBF-1_Associated |
| | | WBPaper00036123:Atrazine_regulated |
| | | WBPaper00036286:Pattern_H |
| | | WBPaper00036429:glp-1(oz112)_upregulated |
| | | WBPaper00038427:lin-54_embryo_changed |
| | | WBPaper00038427:lin-54_germline_changed |
| | | WBPaper00040426:CYD-1_CDK-4_upregulated |
| | | WBPaper00040426:CYE-1_CDK-2AF_upregulated |
| | | WBPaper00041002:HF_3d_2.0mM_Down |
| | | WBPaper00041606:CE_B.thuringiensis-DB27_regulated |
| | | WBPaper00041606:CE_S.marcescens_regulated |
| | | WBPaper00041606:CE_X.nematophila_regulated |
| | | WBPaper00041939:control_vs_EtBr-exposed_48h |
| | | WBPaper00041939:control_vs_UVC-EtBr-exposed_48h |
| | | WBPaper00041939:control_vs_UVC-exposed_51h |
| | | WBPaper00041939:EtBr-exposed_vs_UVC-exposed_51h |
| | | WBPaper00045960:L1-L4-lethargus_downregulated |
| | | WBPaper00045960:L4-lethargus_downregulated |
| | | WBPaper00047070:N2_starvation_downregulated |
| | | WBPaper00048637:lin-35(n745)_starvation_upregulated |
| | | WBPaper00053236:Starvation_regulated_GR1307 |
| | | WBPaper00053236:Starvation_regulated_N2 |
| | | [cgc6390]:intrinsic |
| | Interaction (82) |
| | WBProcess | WBbiopr:00000017 |
| Map_info | Map | III | Position | -0.210379 | Error | 0.001277 |
| | Positive | Positive_clone | F22B7 | Inferred_automatically | From sequence, transcript, pseudogene data |
| | Pseudo_map_position |
| Reference (69) |
| Remark | Sequence connection from [Ahringer JA] |
| | Gene renamed from ags-3.2 to gpr-1 following advice from [Hodgkin J], [020808 krb] |
| | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission |
| Method | Gene |
