| WBGene00001578 | SMap | S_parent | Sequence | R12A1 |
|---|
| Identity | Version | 2 |
| | Name | CGC_name | ges-1 | Person_evidence | WBPerson411 |
| | | | | | WBPerson36909 |
| | | | | | WBPerson7188 |
| | | Sequence_name | R12A1.4 |
| | | Molecular_name | R12A1.4 |
| | | | R12A1.4.1 |
| | | | CE28763 |
| | | Other_name | ges1 | Accession_evidence | EMBL | M96145 |
| | | | cest-18 |
| | | | CELE_R12A1.4 | Accession_evidence | NDB | BX284605 |
| | | Public_name | ges-1 |
| | DB_info | Database (11) |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:25 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | | | 2 | 20 May 2019 14:10:26 | WBPerson1983 | Name_change | CGC_name | ges-1 |
| | | | | | | | Other_name | cest-18 |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | ges |
| | Allele (102) |
| | Legacy_information | cal : electrophoretic variant of major gut esterase. No other phenotype. ES1 ME3. NA6 (ca4 etc. : all electrophoretic variants). |
| | | [C.elegansII] cal : electrophoretic variant of major gut esterase. No other phenotype. ES1 ME3. OA>10: ca4, ca6 etc (all electrophoretic variants), ca6ca7, ca6ca9, ca10, ca11 etc (null mutations, major gut esterase activity absent, no other phenotype) pk47, pk49 (Tc1 insertions; deletionderivatives also obtained). Cloned: encodes gut-specific esterase,expressed from 200-cell stage onward. Extensive promoter analysis. [McGhee et al. 1990, Aamodt et al. 1991, JM] |
| | Strain (15) |
| | RNASeq_FPKM (74) |
| | GO_annotation | 00052613 |
| | | 00052614 |
| | | 00052615 |
| | | 00052616 |
| | | 00052617 |
| | | 00052618 |
| | | 00052619 |
| | | 00052620 |
| | | 00052621 |
| | Ortholog (75) |
| | Paralog (40) |
| | Structured_description | Concise_description | ges-1 encodes a gut-specific type B carboxylesterase; by homology, GES-1 hydrolyzes carboxylic ester substrates to yield an alcohol and a carboxylic anion, however, loss of GES-1 activity via mutation or RNAi does not result in any obvious abnormalities; GES-1 is expressed solely in the intestinal, or E, lineage from the 4 E-cell stage of gut development through adulthood; GES-1 contains a C-terminal endoplasmic reticulum (ER) retention sequence, KDEL, which suggests that it localizes to the ER lumen; GES-1 expression in the gut appears to be positively regulated by ELT-2, a gut-specific GATA-type transcription factor expressed throughout the C. elegans life cycle and essential for normal gut development. | Paper_evidence | WBPaper00000869 |
| | | | | | WBPaper00001305 |
| | | | | | WBPaper00001695 |
| | | | | | WBPaper00003129 |
| | | | | | WBPaper00004994 |
| | | | | Curator_confirmed | WBPerson1843 |
| | | | | Date_last_updated | 15 Feb 2005 00:00:00 |
| | | Automated_description | Enables carboxylesterase activity. Involved in cellular catabolic process. Located in peroxisome. Expressed in pharynx. Human ortholog(s) of this gene implicated in colorectal cancer; hepatocellular carcinoma; and stomach cancer. Is an ortholog of human CES1 (carboxylesterase 1). | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Disease_info | Potential_model | DOID:9256 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1863) |
| | | DOID:3119 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1863) |
| | | DOID:10534 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1863) |
| | | DOID:684 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1863) |
| Molecular_info | Corresponding_CDS | R12A1.4 |
| | Corresponding_transcript | R12A1.4.1 |
| | Other_sequence (12) |
| | Associated_feature | WBsf919554 |
| | | WBsf919555 |
| | | WBsf919556 |
| | | WBsf919557 |
| | | WBsf919558 |
| | | WBsf999325 |
| | | WBsf1019177 |
| | | WBsf233333 |
| Experimental_info | RNAi_result | WBRNAi00063184 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00017787 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00051827 | Inferred_automatically | RNAi_primary |
| | Expr_pattern | Expr683 |
| | | Expr684 |
| | | Expr10319 |
| | | Expr10320 |
| | | Expr11336 |
| | | Expr1028070 |
| | | Expr1030944 |
| | | Expr1155486 |
| | | Expr2012022 |
| | | Expr2030258 |
| | Drives_construct (93) |
| | Construct_product | WBCnstr00018781 |
| | | WBCnstr00018782 |
| | | WBCnstr00036850 |
| | Microarray_results (19) |
| | Expression_cluster | WBPaper00030894:daf-2(e1370ts)_upregulated |
| | | WBPaper00031040:Cluster_3 |
| | | WBPaper00031040:TGF-beta_adult_upregulated |
| | | WBPaper00032425:down_in_alg-1 |
| | | WBPaper00032425:down_in_rde-4 |
| | | WBPaper00032425:down_in_zfp-1 |
| | | WBPaper00037950:bodywall-muscle_L1-larva_expressed |
| | | WBPaper00037950:germline-precursors_blastula-embryo_expressed |
| | | WBPaper00037950:hypodermis_L1-larva_expressed |
| | | WBPaper00037950:intestine_embryo_enriched |
| | | WBPaper00037950:intestine_embryo_SelectivelyEnriched |
| | | WBPaper00037950:intestine_L1-larva_expressed |
| | | WBPaper00037950:pharyngeal-muscle_embryo_enriched |
| | | WBPaper00037950:pharyngeal-muscle_embryo_SelectivelyEnriched |
| | | WBPaper00037950:pharyngeal-muscle_L1-larva_expressed |
| | | WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed |
| | | WBPaper00038168:lin-15B(n744)_downregulated |
| | | WBPaper00038438:S.marcescens_24hr_upregulated_RNAseq |
| | | WBPaper00038438:S.marcescens_24hr_upregulated_TilingArray |
| | | WBPaper00042561:smgl-1(RNAi)_downregulated |
| | | WBPaper00044030:nhr-8(hd117)_downregulated |
| | | WBPaper00044316:HgCl2_7.5uM_upregulated |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00045521:Gender_Neutral |
| | | WBPaper00045571:germline-ablation_upregulated |
| | | WBPaper00045774:clk-1_upregulated |
| | | WBPaper00046121:endoderm_unique |
| | | WBPaper00046337:monosomal_N2_vs_daf-2_downregulated |
| | | WBPaper00046337:polysomal_daf-2_vs_daf-2;daf-16_downregulated |
| | | WBPaper00046337:polysomal_N2_vs_daf-2_downregulated |
| | | WBPaper00046497:B.thuringiensis_0.1mix_downregulated_6h |
| | | WBPaper00046497:B.thuringiensis_0.1mix_downregulated_12h |
| | | WBPaper00046497:B.thuringiensis_0.5mix_downregulated_6h |
| | | WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h |
| | | WBPaper00047131:daf-2(e1370)_upregulated_N2-background |
| | | WBPaper00047132:glp-1(ts)-25C_upregulated |
| | | WBPaper00048926:miaserin_upregulated_adult-day10 |
| | | WBPaper00048952:glucose_induced |
| | | WBPaper00049134:hpk-1(pk1393)_downregulated |
| | | WBPaper00049217:DAF-16_upregulated |
| | | WBPaper00049484:elt-2(RNAi)_downregulated_L4 |
| | | WBPaper00049545:jmjd-3.1(+)_upregulated |
| | | WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated |
| | | WBPaper00049545:sur-5p-jmjd-1.2(+)_upregulated |
| | | WBPaper00049736:daf-2(e1370)_upregulated_15deg-then-25deg(12hr) |
| | | WBPaper00049942:hsf-1(RNAi)_downregulated |
| | | WBPaper00050080:rbr-2(tm3141)_upregulated |
| | | WBPaper00050163:chd-3(eh4);let-418(RNAi)_downregulated_24-cell-embryo |
| | | WBPaper00050370:dpy-21(e428)_L3_downregulated |
| | | WBPaper00050726:OsmoticStress_regulated_Food |
| | | WBPaper00050726:OsmoticStress_regulated_NoFood |
| | | WBPaper00050801:DAF-16_dauer_regulome |
| | | WBPaper00050801:DPY-21_dauer_regulome |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day1-adult |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult |
| | | WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult |
| | | WBPaper00050990:intestine_enriched |
| | | WBPaper00050990:intestine_expressed |
| | | WBPaper00051039:ash-2(RNAi)_regulated_intestine |
| | | WBPaper00051039:intestine_enriched |
| | | WBPaper00051265:F4_morc-1(tm6048)_downregulated |
| | | WBPaper00051305:vit-2(ac3)_downregulated |
| | | WBPaper00051404:alg-1(gk214)_downregulated |
| | | WBPaper00052884:emb-4(hc60)_upregulated |
| | | WBPaper00053184:sma-2(rax5)_upregulated |
| | | WBPaper00053184:sma-4(rax3)_upregulated |
| | | WBPaper00053388:dauer_regulated_Cluster3 |
| | | WBPaper00053599:female_vs_male_downregulated |
| | | WBPaper00053606:elt-2(ca15)_vs_elt-2(ca15);elt-7(tm840)_doenregulated |
| | | WBPaper00053713:Starvation-induced_postdauer_vs_control_upregulated |
| | | WBPaper00053810:daf-2(e1370)_upregulated |
| | | WBPaper00054758:alg-1(gk204)_downregulated |
| | | WBPaper00055364:uaf-1(n4588)_downregulated |
| | | WBPaper00055386:daf-2(e1370)_upregulated |
| | | WBPaper00055827:daf-2(e1370)_upregulated |
| | | WBPaper00055862:antimycin_damt-1(gk961032)_regulated |
| | | WBPaper00055941:atfs-1(et15)_upregulated |
| | | WBPaper00055971:nhl-2(ok818)_25C_upregulated |
| | | WBPaper00056034:pals-22(jy3)_downregulated |
| | | WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047) |
| | | WBPaper00056169:rrf-3(pk1426)_upregulated_embryo |
| | | WBPaper00056284:ints-2(RNAi)_downregulated |
| | | WBPaper00056293:rpl-5(0)-rpl-33(0)_downregulated |
| | | WBPaper00056326:zip-3(gk3164)_upregulated_P.aeruginosa-infected |
| | | WBPaper00056471:aak-1(tm1944);aak-2(ok524)_downregulated |
| | | WBPaper00056471:S.aureus-4h_upregulated_N2 |
| | | WBPaper00056550:ceh-60(ok1485)_upregulated_AdultDay1 |
| | | WBPaper00056826:hmc_biased |
| | | WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C |
| | | WBPaper00057006:DietaryRestriction_downregulated |
| | | WBPaper00057041:unc-70(cas983)_downregulated |
| | | WBPaper00058598:sin-3(tm1276)_downregulated |
| | | WBPaper00058665:graphene-oxide_upregulated_mRNA |
| | | WBPaper00058691:sin-3(tm1276)_downregulated |
| | | WBPaper00059253:stearic-acid_upregulated |
| | | WBPaper00059253:sucrose_stearic-acid_upregulated |
| | | WBPaper00059253:sucrose_upregulated |
| | | WBPaper00059328:mrps-5(RNAi)_upregulated_protein |
| | | WBPaper00059824:rnp-6(dh1127)_regulated_S.aureus |
| | | WBPaper00059839:S.maltophilia_regulated |
| | | WBPaper00059895:wounding_downregulated |
| | | WBPaper00060014:set-2(tm1630)_downregulated |
| | | WBPaper00060358:B.thuringiensis_non-pathogen_regulated_elt-2(RNAi) |
| | | WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi) |
| | | WBPaper00060358:B.thuringiensis_pathogen_regulated_N2 |
| | | WBPaper00060661:sensory-neuron_depleted |
| | | WBPaper00060911:prx-5(RNAi)_upregulated_mRNA |
| | | WBPaper00061203:let-418(n3536)_upregulated |
| | | WBPaper00061203:sin-3(tm1276)_upregulated |
| | | WBPaper00061203:spr-1(ok2144)_upregulated |
| | | WBPaper00061340:Intestine |
| | | WBPaper00061341:28C_24h_upregulated |
| | | WBPaper00061439:unc-30(ok613)_upregulated_P.aeruginosa-infection |
| | | WBPaper00061527:dhs-28_22199-acs-14 |
| | | WBPaper00061530:nhr-49(e2144)_downregulated |
| | | WBPaper00061699:daf-18(ok480)_downregulated |
| | | WBPaper00062159:hda-2(ok1479)_upregulated |
| | | WBPaper00062193:skn-1(RNAi)_upregulated |
| | | WBPaper00062325:etr-1(lq61)_downregulated |
| | | WBPaper00062325:muscle_depleted_coding-RNA |
| | | WBPaper00062669:extracellular-vesicle_protein |
| | | WBPaper00064071:NHR-49_interacting |
| | | WBPaper00064088:Day-1-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141) |
| | | WBPaper00064088:Day-1-adult_vs_L4_upregulated_fem-3(q20) |
| | | WBPaper00064088:Day-1-adult_vs_L4_upregulated_glp-1(e2141) |
| | | WBPaper00064088:Day-3-adult_vs_L4_upregulated_fem-3(q20) |
| | | WBPaper00064088:Day-3-adult_vs_L4_upregulated_glp-1(e2141) |
| | | WBPaper00064229:B.thuringiensis-Cry5Ba_upregulated |
| | | WBPaper00064494:postdauer_downregulated_AWA |
| | | WBPaper00064632:daf-2(e1370)_upregulated_intestine |
| | | WBPaper00064716:paraquat_downregulated |
| | | WBPaper00064727:daf-2(e1370)_upregulated |
| | | WBPaper00064933:bcf-1(ylf1)_downregulated_transcript |
| | | WBPaper00064939:vit-5(RNAi)_upregulated |
| | | WBPaper00065029:cadmium_upregulated |
| | | WBPaper00065086:JU1400_N.ferruginous_regulated |
| | | WBPaper00065086:N2_N.ausubeli_regulated |
| | | WBPaper00065120:body-muscle-transcriptome |
| | | WBPaper00065373:Cisplatin_downregulated_WT |
| | | WBPaper00065392:Lb.plantarum_downregulated |
| | | WBPaper00065581:hpk-1(pk1393)_downregulated |
| | | WBPaper00065835:Day11_vs_Day1_downregulated |
| | | WBPaper00065835:mtH2S-AP39-D0-treatment_upregulated_Day11 |
| | | WBPaper00065841:27_0 |
| | | WBPaper00065841:34_1 |
| | | WBPaper00065841:79_0 |
| | | WBPaper00065841:79_2 |
| | | WBPaper00065945:epidermis-rpoa-2(-)_upregulated_protein |
| | | WBPaper00065975:P-body_vs_WholeAnimal_depleted |
| | | WBPaper00065984:pals-17(syb3980)_downregulated |
| | | WBPaper00065993:glp-1(e2141)_upregulated |
| | | WBPaper00066038:mip-1(how5)_upregulated |
| | | WBPaper00066146:germline-inx-14(RNAi)_upregulated_PA14 |
| | | WBPaper00066232:hsf-1(RNAi)_downregulated_ash-2 |
| | | WBPaper00066232:hsf-1(RNAi)_downregulated_WT |
| | | cgc4386_cluster_1_2 |
| | | cgc4489_group_8 |
| | | WBPaper00025032:cluster_37 |
| | | WBPaper00026929:sir-2.1_overexpression_regulated |
| | | WBPaper00029437:rde-4_upregulated |
| | | WBPaper00031532:Larva_Pan_Neuronal_Depleted |
| | | WBPaper00032062:age_regulated_genes |
| | | WBPaper00032165:differentially_expressed_with_age_medoid_4 |
| | | WBPaper00032948:StarveUp3 |
| | | WBPaper00035873:dpy-9_regulated |
| | | WBPaper00035873:dpy-10_regulated |
| | | WBPaper00036130:mir-243_down_regulated |
| | | WBPaper00036286:Pattern_C |
| | | WBPaper00038172:tax-6null_down_regulated |
| | | WBPaper00038231:Cry5B_1.5-fold_downregulated |
| | | WBPaper00038231:Cry5B_2-fold_downregulated |
| | | WBPaper00038304:octr-1_regulated |
| | | WBPaper00040184:hcf-1up_sir-2.1up_daf-2up |
| | | WBPaper00040210:Chlorpyrifos_24C_regulated |
| | | WBPaper00040963:TA300_up |
| | | WBPaper00041002:HQ_3d_2.0mM_Up |
| | | WBPaper00041370:spg-7(RNAi)_upregulated |
| | | WBPaper00041606:CE_X.nematophila_regulated |
| | | WBPaper00041939:control_vs_EtBr-exposed_3h |
| | | WBPaper00041939:control_vs_EtBr-exposed_24h |
| | | WBPaper00041939:control_vs_EtBr-exposed_48h |
| | | WBPaper00041939:control_vs_UVC-EtBr-exposed_24h |
| | | WBPaper00041939:control_vs_UVC-EtBr-exposed_48h |
| | | WBPaper00041939:control_vs_UVC-EtBr-exposed_51h |
| | | WBPaper00041939:EtBr-exposed_vs_UVC-exposed_3h |
| | | WBPaper00041960:N2_fasting_upregulated_9hto12h |
| | | WBPaper00041960:N2_fasting_upregulated_anytime |
| | | WBPaper00044091:Bpseudomallei_repressed_8h |
| | | WBPaper00044091:Bpseudomallei_repressed_12h |
| | | WBPaper00044535:male_downregulated |
| | | WBPaper00045263:nuo-6(qm200)_upregulated |
| | | WBPaper00045673:colistin_upregulated |
| | | WBPaper00047070:N2_starvation_upregulated |
| | | WBPaper00048989:eat-2(ad465)_upregulated_in-DMSO |
| | | WBPaper00048989:N2_allantoin_downregulated |
| | | WBPaper00048989:N2_rapamycin_downregulated |
| | | WBPaper00053236:Starvation_regulated_GR1307 |
| | | WBPaper00053236:Starvation_regulated_N2 |
| | | WBPaper00057098:SiO2-nanoparticles_downregulated |
| | | [cgc5976]:class_1 |
| | | [cgc6390]:Cluster_C |
| | | [cgc6390]:herm_soma-enriched |
| | Interaction (43) |
| Map_info | Map | V | Position | -18.9452 | Error | 0.035025 |
| | Well_ordered |
| | Positive | Positive_clone | JM#L0001 |
| | | | R12A1 | Inferred_automatically | From sequence, transcript, pseudogene data |
| | Mapping_data | 2_point | 3138 |
| | | | 3139 |
| | | | 3140 |
| | | | 3141 |
| | | Multi_point | 1188 |
| | | Pos_neg_data | 3142 |
| | | | 3143 |
| | | | 3144 |
| | | | 4540 |
| | | | 5191 |
| Reference (109) |
| Method | Gene |
