WormBase Tree Display for Gene: WBGene00001519
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| WBGene00001519 | SMap | S_parent | Sequence | CHROMOSOME_V | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | gar-3 | Person_evidence | WBPerson32 | |||||
| Sequence_name | Y40H4A.1 | ||||||||
| Molecular_name | Y40H4A.1a | ||||||||
| Y40H4A.1a.1 | |||||||||
| CE27783 | |||||||||
| Y40H4A.1b | |||||||||
| CE35800 | |||||||||
| Y40H4A.1a.2 | |||||||||
| Y40H4A.1a.3 | |||||||||
| Y40H4A.1b.1 | |||||||||
| Other_name | acm-3 | ||||||||
| gar-3a | Accession_evidence | EMBL | AY221631 | ||||||
| CELE_Y40H4A.1 | Accession_evidence | NDB | BX284605 | ||||||
| Public_name | gar-3 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:24 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | gar | ||||||||
| Allele (594) | |||||||||
| Strain | WBStrain00022220 | ||||||||
| WBStrain00035957 | |||||||||
| WBStrain00035965 | |||||||||
| WBStrain00022221 | |||||||||
| WBStrain00022222 | |||||||||
| WBStrain00052083 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (32) | |||||||||
| Ortholog (57) | |||||||||
| Paralog (17) | |||||||||
| Structured_description | Concise_description | gar-3 encodes a G protein-linked muscarinic acetylcholine receptor; GAR-3 activity is required for regulation of membrane potential and excitation-contraction coupling in pharyngeal muscle and thus, for normal feeding behavior; in regulating pharyngeal pumping, GAR-3 likely acts upstream of GPB-2, a G-protein beta-subunit; GAR-3 also acts cell-autonomously in motor neurons to recruit the SPHK-1 sphingosine kinase to presynaptic acetylcholine release sites; a gar-3::gfp reporter fusion is expressed in the I3 pharyngeal neuron, extrapharyngeal neurons, and in pharyngeal muscles, where expression is highest in the terminal bulb. | Paper_evidence | WBPaper00003864 | |||||
| WBPaper00024250 | |||||||||
| WBPaper00041106 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 24 Oct 2013 00:00:00 | ||||||||
| Automated_description | Enables G protein-coupled acetylcholine receptor activity. Involved in several processes, including G protein-coupled acetylcholine receptor signaling pathway; positive regulation of acetylcholine secretion, neurotransmission; and positive regulation of protein localization to synapse. Located in plasma membrane. Expressed in body wall musculature; linker cell; neurons; non-striated muscle; and somatic nervous system. Human ortholog(s) of this gene implicated in several diseases, including Chagas disease; autoimmune disease of the nervous system (multiple); and lung disease (multiple). Is an ortholog of human CHRM1 (cholinergic receptor muscarinic 1); CHRM3 (cholinergic receptor muscarinic 3); and CHRM5 (cholinergic receptor muscarinic 5). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model (13) | ||||||||
| Molecular_info | Corresponding_CDS | Y40H4A.1a | |||||||
| Y40H4A.1b | |||||||||
| Corresponding_CDS_history | Y40H4A.1:wp51 | ||||||||
| Corresponding_transcript | Y40H4A.1a.1 | ||||||||
| Y40H4A.1a.2 | |||||||||
| Y40H4A.1a.3 | |||||||||
| Y40H4A.1b.1 | |||||||||
| Other_sequence (40) | |||||||||
| Associated_feature (16) | |||||||||
| Experimental_info | RNAi_result | WBRNAi00027900 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00056336 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00092909 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00012332 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00108394 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00020457 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern (12) | |||||||||
| Drives_construct | WBCnstr00011074 | ||||||||
| WBCnstr00013244 | |||||||||
| WBCnstr00013245 | |||||||||
| WBCnstr00018255 | |||||||||
| WBCnstr00019493 | |||||||||
| WBCnstr00036892 | |||||||||
| Construct_product | WBCnstr00001301 | ||||||||
| WBCnstr00013245 | |||||||||
| WBCnstr00018107 | |||||||||
| WBCnstr00018108 | |||||||||
| WBCnstr00018255 | |||||||||
| WBCnstr00036892 | |||||||||
| Microarray_results (29) | |||||||||
| Expression_cluster (178) | |||||||||
| Interaction (18) | |||||||||
| Map_info | Map | V | Position | 6.49683 | Error | 0.009424 | |||
| Positive | Positive_clone | Y40H4A | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Mapping_data | Multi_point | 4335 | |||||||
| 4959 | |||||||||
| 5533 | |||||||||
| Pseudo_map_position | |||||||||
| Reference (56) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
