WormBase Tree Display for Gene: WBGene00001194
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WBGene00001194 | SMap | S_parent | Sequence | C04A2 | |||||
---|---|---|---|---|---|---|---|---|---|
Identity | Version | 1 | |||||||
Name | CGC_name | egl-27 | Person_evidence | WBPerson268 | |||||
Sequence_name | C04A2.3 | ||||||||
Molecular_name (60) | |||||||||
Other_name | CELE_C04A2.3 | Accession_evidence | NDB | BX284602 | |||||
Public_name | egl-27 | ||||||||
DB_info | Database (12) | ||||||||
Species | Caenorhabditis elegans | ||||||||
History | Version_change | 1 | 07 Apr 2004 11:29:23 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
Status | Live | ||||||||
Gene_info | Biotype | SO:0001217 | |||||||
Gene_class | egl | ||||||||
Reference_allele | WBVar00089296 | ||||||||
Allele (248) | |||||||||
Legacy_information | n170 : variable bloating moderate to severe Type E; possibly abnormal vulva; males very abnormal : reduced rays short spicules swollen bursa hermaphroditic tail spike. ES2 (adult). ES3 (adult male). ME0. NA1. | ||||||||
See also e2394, n170 | |||||||||
[C.elegansII] n170 : variable bloating, moderate to severe; variable drug response; possibly abnormal vulva; Mig; males Lin, very abnormal : reduced rays, short spicules, swollen bursa, hermaphroditic tail spike. ES2 (adult). ES3 (adult male).ME0. OA1: e2394. [Trent et al. 1983; Desai et al. 1988; CZ; MT] | |||||||||
Complementation_data | [Chisholm AD] complements let-263 | ||||||||
Strain (13) | |||||||||
RNASeq_FPKM (74) | |||||||||
GO_annotation (41) | |||||||||
Contained_in_operon | CEOP2739 | ||||||||
Ortholog (36) | |||||||||
Paralog | WBGene00003025 | Caenorhabditis elegans | From_analysis | TreeFam | |||||
Structured_description | Concise_description | egl-27 encodes, along with lin-40, one of two C. elegans homologs of human MTA1 (metastasis-associated protein), part of a nucleosome remodeling and histone deacetylation (NURD) complex; in conjunction with its paralog egr-1, egl-27 is required for proper organization in all parts of the embryo, and for the embryonic expression of hlh-8; egl-27 activity is also required for transdifferentiation of the Y rectal cell to the PDA neuron during larval development; EGL-27 acts downstream of DAF-2 and recognizes the GATA/DAE (DAF-16-associated element) promoter motif of DAF-16 target genes; together with DAF-16 it promotes developmental growth in response to DNA damage. | Paper_evidence | WBPaper00003578 | |||||
WBPaper00005068 | |||||||||
WBPaper00012788 | |||||||||
WBPaper00012830 | |||||||||
WBPaper00012882 | |||||||||
WBPaper00012897 | |||||||||
WBPaper00013003 | |||||||||
WBPaper00040964 | |||||||||
WBPaper00047070 | |||||||||
Person_evidence | WBPerson4498 | ||||||||
Curator_confirmed | WBPerson1843 | ||||||||
WBPerson567 | |||||||||
Date_last_updated | 28 Oct 2015 00:00:00 | ||||||||
Automated_description | Enables RNA polymerase II-specific DNA-binding transcription factor binding activity; chromatin binding activity; and enzyme binding activity. Involved in several processes, including egg-laying behavior; hemidesmosome assembly; and nematode male tail tip morphogenesis. Located in nucleus. Expressed in several structures, including Y cell; intestinal cell; neurons; pharynx; and somatic gonad precursor. Human ortholog(s) of this gene implicated in dentatorubral-pallidoluysian atrophy and schizophrenia. Is an ortholog of human RERE (arginine-glutamic acid dipeptide repeats). | Paper_evidence | WBPaper00065943 | ||||||
Curator_confirmed | WBPerson324 | ||||||||
WBPerson37462 | |||||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
Disease_info | Potential_model | DOID:0060162 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:3033) | ||||
DOID:5419 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:3033) | ||||||
Molecular_info | Corresponding_CDS (18) | ||||||||
Corresponding_CDS_history | C04A2.3:wp81 | ||||||||
C04A2.3b:wp233 | |||||||||
Corresponding_transcript (24) | |||||||||
Other_sequence | CR05536 | ||||||||
Dviv_isotig29307 | |||||||||
ACC25123_1 | |||||||||
FK807587.1 | |||||||||
EX545412.1 | |||||||||
HBC01123_1 | |||||||||
CBC16181_1 | |||||||||
Oden_isotig22916 | |||||||||
ACC05418_1 | |||||||||
BMC00485_1 | |||||||||
Oden_isotig17203 | |||||||||
JI164933.1 | |||||||||
EX011533.1 | |||||||||
ACC27472_1 | |||||||||
CR00735 | |||||||||
EX552944.1 | |||||||||
EX828249.1 | |||||||||
ACC03631_1 | |||||||||
EY466640.1 | |||||||||
Oden_isotig17204 | |||||||||
EY467671.1 | |||||||||
EX546704.1 | |||||||||
CRC00467_1 | |||||||||
Associated_feature (42) | |||||||||
Gene_product_binds (1510) | |||||||||
Transcription_factor | WBTranscriptionFactor000021 | ||||||||
Experimental_info | RNAi_result (77) | ||||||||
Expr_pattern (17) | |||||||||
Drives_construct | WBCnstr00003554 | ||||||||
WBCnstr00007732 | |||||||||
WBCnstr00010198 | |||||||||
WBCnstr00012481 | |||||||||
WBCnstr00014527 | |||||||||
WBCnstr00015226 | |||||||||
WBCnstr00015227 | |||||||||
WBCnstr00015228 | |||||||||
WBCnstr00017088 | |||||||||
WBCnstr00037037 | |||||||||
Construct_product | WBCnstr00007732 | ||||||||
WBCnstr00010198 | |||||||||
WBCnstr00012481 | |||||||||
WBCnstr00016564 | |||||||||
WBCnstr00017088 | |||||||||
WBCnstr00037037 | |||||||||
Microarray_results (42) | |||||||||
Expression_cluster (160) | |||||||||
Interaction (170) | |||||||||
Anatomy_function | WBbtf0744 | ||||||||
Product_binds_matrix | WBPmat00005570 | ||||||||
WBPmat00005580 | |||||||||
WBProcess | WBbiopr:00000020 | ||||||||
WBbiopr:00000024 | |||||||||
WBbiopr:00000071 | |||||||||
WBbiopr:00000072 | |||||||||
Map_info | Map | II | Position | 0.116063 | Error | 0.000615 | |||
Well_ordered | |||||||||
Positive | Positive_clone | C04A2 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
Mapping_data | 2_point | 735 | |||||||
Multi_point | 631 | ||||||||
1718 | |||||||||
1719 | |||||||||
2310 | |||||||||
2311 | |||||||||
Pos_neg_data | 6857 | ||||||||
6858 | |||||||||
Reference (85) | |||||||||
Picture | WBPicture0000013092 | ||||||||
Method | Gene |