WormBase Tree Display for Gene: WBGene00001194
expand all nodes | collapse all nodes | view schema
| WBGene00001194 | SMap | S_parent | Sequence | C04A2 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | egl-27 | Person_evidence | WBPerson268 | |||||
| Sequence_name | C04A2.3 | ||||||||
| Molecular_name (60) | |||||||||
| Other_name | CELE_C04A2.3 | Accession_evidence | NDB | BX284602 | |||||
| Public_name | egl-27 | ||||||||
| DB_info | Database (12) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:23 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | egl | ||||||||
| Reference_allele | WBVar00089296 | ||||||||
| Allele (248) | |||||||||
| Legacy_information | n170 : variable bloating moderate to severe Type E; possibly abnormal vulva; males very abnormal : reduced rays short spicules swollen bursa hermaphroditic tail spike. ES2 (adult). ES3 (adult male). ME0. NA1. | ||||||||
| See also e2394, n170 | |||||||||
| [C.elegansII] n170 : variable bloating, moderate to severe; variable drug response; possibly abnormal vulva; Mig; males Lin, very abnormal : reduced rays, short spicules, swollen bursa, hermaphroditic tail spike. ES2 (adult). ES3 (adult male).ME0. OA1: e2394. [Trent et al. 1983; Desai et al. 1988; CZ; MT] | |||||||||
| Complementation_data | [Chisholm AD] complements let-263 | ||||||||
| Strain (13) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation | 00000616 | ||||||||
| 00000617 | |||||||||
| 00000618 | |||||||||
| 00052948 | |||||||||
| 00052949 | |||||||||
| 00052950 | |||||||||
| 00052951 | |||||||||
| 00052952 | |||||||||
| 00052953 | |||||||||
| 00052954 | |||||||||
| 00052955 | |||||||||
| 00052956 | |||||||||
| 00052957 | |||||||||
| 00052958 | |||||||||
| 00052959 | |||||||||
| 00052960 | |||||||||
| 00052961 | |||||||||
| 00052962 | |||||||||
| 00052963 | |||||||||
| 00052964 | |||||||||
| 00052965 | |||||||||
| 00052966 | |||||||||
| 00052967 | |||||||||
| 00052968 | |||||||||
| 00052969 | |||||||||
| 00052970 | |||||||||
| 00052971 | |||||||||
| 00052972 | |||||||||
| 00052973 | |||||||||
| 00052974 | |||||||||
| 00052975 | |||||||||
| 00052976 | |||||||||
| 00052977 | |||||||||
| 00052978 | |||||||||
| 00052979 | |||||||||
| 00052980 | |||||||||
| 00052981 | |||||||||
| 00052982 | |||||||||
| 00108430 | |||||||||
| 00108431 | |||||||||
| 00108432 | |||||||||
| Contained_in_operon | CEOP2739 | ||||||||
| Ortholog (36) | |||||||||
| Paralog | WBGene00003025 | Caenorhabditis elegans | From_analysis | TreeFam | |||||
| Structured_description | Concise_description | egl-27 encodes, along with lin-40, one of two C. elegans homologs of human MTA1 (metastasis-associated protein), part of a nucleosome remodeling and histone deacetylation (NURD) complex; in conjunction with its paralog egr-1, egl-27 is required for proper organization in all parts of the embryo, and for the embryonic expression of hlh-8; egl-27 activity is also required for transdifferentiation of the Y rectal cell to the PDA neuron during larval development; EGL-27 acts downstream of DAF-2 and recognizes the GATA/DAE (DAF-16-associated element) promoter motif of DAF-16 target genes; together with DAF-16 it promotes developmental growth in response to DNA damage. | Paper_evidence | WBPaper00003578 | |||||
| WBPaper00005068 | |||||||||
| WBPaper00012788 | |||||||||
| WBPaper00012830 | |||||||||
| WBPaper00012882 | |||||||||
| WBPaper00012897 | |||||||||
| WBPaper00013003 | |||||||||
| WBPaper00040964 | |||||||||
| WBPaper00047070 | |||||||||
| Person_evidence | WBPerson4498 | ||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 28 Oct 2015 00:00:00 | ||||||||
| Automated_description | Enables RNA polymerase II-specific DNA-binding transcription factor binding activity; chromatin binding activity; and enzyme binding activity. Involved in several processes, including egg-laying behavior; hemidesmosome assembly; and nematode male tail tip morphogenesis. Located in nucleus. Expressed in several structures, including Y cell; intestinal cell; neurons; pharynx; and somatic gonad precursor. Human ortholog(s) of this gene implicated in dentatorubral-pallidoluysian atrophy and schizophrenia. Is an ortholog of human RERE (arginine-glutamic acid dipeptide repeats). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0060162 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:3033) | ||||
| DOID:5419 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:3033) | ||||||
| Molecular_info | Corresponding_CDS (18) | ||||||||
| Corresponding_CDS_history | C04A2.3:wp81 | ||||||||
| C04A2.3b:wp233 | |||||||||
| Corresponding_transcript (24) | |||||||||
| Other_sequence (23) | |||||||||
| Associated_feature (42) | |||||||||
| Gene_product_binds (1510) | |||||||||
| Transcription_factor | WBTranscriptionFactor000021 | ||||||||
| Experimental_info | RNAi_result (77) | ||||||||
| Expr_pattern (17) | |||||||||
| Drives_construct | WBCnstr00003554 | ||||||||
| WBCnstr00007732 | |||||||||
| WBCnstr00010198 | |||||||||
| WBCnstr00012481 | |||||||||
| WBCnstr00014527 | |||||||||
| WBCnstr00015226 | |||||||||
| WBCnstr00015227 | |||||||||
| WBCnstr00015228 | |||||||||
| WBCnstr00017088 | |||||||||
| WBCnstr00037037 | |||||||||
| Construct_product | WBCnstr00007732 | ||||||||
| WBCnstr00010198 | |||||||||
| WBCnstr00012481 | |||||||||
| WBCnstr00016564 | |||||||||
| WBCnstr00017088 | |||||||||
| WBCnstr00037037 | |||||||||
| Microarray_results (42) | |||||||||
| Expression_cluster (160) | |||||||||
| Interaction (170) | |||||||||
| Anatomy_function | WBbtf0744 | ||||||||
| Product_binds_matrix | WBPmat00005570 | ||||||||
| WBPmat00005580 | |||||||||
| WBProcess | WBbiopr:00000020 | ||||||||
| WBbiopr:00000024 | |||||||||
| WBbiopr:00000071 | |||||||||
| WBbiopr:00000072 | |||||||||
| Map_info | Map | II | Position | 0.116063 | Error | 0.000615 | |||
| Well_ordered | |||||||||
| Positive | Positive_clone | C04A2 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | 2_point | 735 | |||||||
| Multi_point | 631 | ||||||||
| 1718 | |||||||||
| 1719 | |||||||||
| 2310 | |||||||||
| 2311 | |||||||||
| Pos_neg_data | 6857 | ||||||||
| 6858 | |||||||||
| Reference (85) | |||||||||
| Picture | WBPicture0000013092 | ||||||||
| Method | Gene |
