WormBase Tree Display for Gene: WBGene00001163

WBGene00001163 SMap: S_parent: Sequence: C43F9
  Identity: Version: 1
    Name: CGC_name: efn-2 Person_evidence: WBPerson893
      Sequence_name: C43F9.8
      Molecular_name: C43F9.8
        C43F9.8.1
        CE35430
      Other_name: CELE_C43F9.8 Accession_evidence: NDB BX284604
      Public_name: efn-2
    DB_info: Database (11)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:23 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: efn
    Allele (22)
    Strain: WBStrain00029134
      WBStrain00029135
      WBStrain00005372
      WBStrain00005375
      WBStrain00005671
    RNASeq_FPKM (74)
    GO_annotation: 00100323
      00100324
      00100325
      00100326
      00100327
      00108358
    Ortholog (52)
    Paralog: WBGene00006869 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00001165 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00001164 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
    Structured_description: Automated_description: Predicted to enable ephrin receptor binding activity. Predicted to be involved in axon guidance and ephrin receptor signaling pathway. Predicted to be located in plasma membrane. Expressed in several structures, including excretory gland cell; head neurons; motor neurons; pharyngeal muscle cell; and retrovesicular ganglion neurons. Human ortholog(s) of this gene implicated in several diseases, including craniofrontonasal syndrome; gastrointestinal system cancer (multiple); and varicose veins. Is an ortholog of human EFNB1 (ephrin B1) and EFNB3 (ephrin B3). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:1520 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:3227)
      DOID:3748 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:3227)
      DOID:1934 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:3226)
      DOID:0080199 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:3227)
      DOID:10534 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:3226,HGNC:3227)
      DOID:799 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:3227)
      DOID:9261 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:3227)
      DOID:14737 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:3226)
  Molecular_info: Corresponding_CDS: C43F9.8
    Corresponding_CDS_history: C43F9.8:wp109
    Corresponding_transcript: C43F9.8.1
    Other_sequence (11)
    Associated_feature (25)
  Experimental_info: RNAi_result: WBRNAi00042393 Inferred_automatically: RNAi_primary
      WBRNAi00022852 Inferred_automatically: RNAi_primary
      WBRNAi00033551 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr8265
      Expr8266
      Expr11224
      Expr1028720
      Expr1030741
      Expr1146384
      Expr2011192
      Expr2029428
    Drives_construct: WBCnstr00013220
      WBCnstr00013221
      WBCnstr00018077
      WBCnstr00037055
    Construct_product: WBCnstr00013220
      WBCnstr00037055
    Microarray_results (17)
    Expression_cluster: WBPaper00031040:TGF-beta_adult_upregulated
      WBPaper00035197:fer-1_downregulated
      WBPaper00037055:DAF-16_binding_DNA
      WBPaper00037682:sma-2_sma-4_upregulated
      WBPaper00037946:EGL-5_interacting
      WBPaper00037950:A-class-motor-neurons_L2-larva_expressed
      WBPaper00037950:all-neurons_L2-larva_expressed
      WBPaper00037950:AVE-neuron_L1-larva_expressed
      WBPaper00037950:bodywall-muscle_L2-larva_expressed
      WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed
      WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
      WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed
      WBPaper00037950:hypodermis_L3-L4-larva_expressed
      WBPaper00037950:hypodermis_larva_enriched
      WBPaper00037950:hypodermis_larva_SelectivelyEnriched
      WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
      WBPaper00038438:D.coniospora_12hr_downregulated_RNAseq
      WBPaper00038438:P.lumniescens_24hr_upregulated_TilingArray
      WBPaper00038438:S.marcescens_24hr_upregulated_RNAseq
      WBPaper00044578:reduced-humidity_downregulated_microarray
      WBPaper00044736:flat_dev_expression
      WBPaper00045521:Gender_Neutral
      WBPaper00045974:NSM_enriched_totalRNA_RNAseq
      WBPaper00046012:tdp-1(ok803)_upregulated
      WBPaper00046121:ecdoderm_unique
      WBPaper00047131:daf-2(e1370)_upregulated_hel-1(gk148684)-background
      WBPaper00047131:daf-2(e1370)_upregulated_N2-background
      WBPaper00048923:Aging_regulated
      WBPaper00048988:neuron_enriched
      WBPaper00048988:neuron_expressed
      WBPaper00049545:cco-1(RNAi)_upregulated
      WBPaper00049545:jmjd-3.1(+)_upregulated
      WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated
      WBPaper00049545:sur-5p-jmjd-1.2(+)_upregulated
      WBPaper00049635:dop-1(vs100)_upregulated
      WBPaper00050053:muscle_enriched_Day4
      WBPaper00050182:lmn-1(L535P)_upregulated
      WBPaper00050344:AFD-neuron_enriched
      WBPaper00050344:ASER-neuron_enriched
      WBPaper00050344:PLM-neuron_enriched
      WBPaper00050412:cco-1(RNAi)_upregulated_N2
      WBPaper00050488:20C_vs_25C_regulated_N2_adult
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050496:unc-39(hp701)_regulated
      WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
      WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult
      WBPaper00050990:body-muscle_expressed
      WBPaper00050990:GABAergic-neuron_expressed
      WBPaper00050990:hypodermis_expressed
      WBPaper00050990:intestine_expressed
      WBPaper00051352:Long-Term-Association-Memory_upregulated
      WBPaper00051404:alg-1(gk214)_upregulated
      WBPaper00051404:alg-2(ok304)_upregulated
      WBPaper00052884:emb-4(hc60)_upregulated
      WBPaper00053184:sma-4(rax3)_upregulated
      WBPaper00053302:stavudine_24h_regulated
      WBPaper00053302:stavudine_72h_regulated
      WBPaper00053302:zidovudine_72h_regulated
      WBPaper00053321:PGCs_depleted_NuGen
      WBPaper00053388:dauer_regulated_Cluster3
      WBPaper00053599:oocyte_vs_mitosis_upregulated
      WBPaper00053606:N2_vs_elt-2(ca15);elt-7(tm840)_downregulated
      WBPaper00053606:N2_vs_elt-2(ca15)_downregulated
      WBPaper00054410:set-26(tm2467)_upregulated
      WBPaper00054758:alg-1(gk204)_upregulated
      WBPaper00055354:Rapamycin-Allantoin_downregulated
      WBPaper00055354:Rapamycin-Psora-Allantoin_upregulated
      WBPaper00055354:Rapamycin-Rifampicin-Allantoin_upregulated
      WBPaper00055354:Rapamycin-Rifampicin-Psora_upregulated
      WBPaper00055354:Rapamycin-Rifampicin_upregulated
      WBPaper00055354:Rifampicin-Psora_upregulated
      WBPaper00055354:Rifampicin_upregulated
      WBPaper00055941:atfs-1(et15)_upregulated
      WBPaper00055971:nhl-2(ok818)_25C_downregulated
      WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047)
      WBPaper00056139:soil-microbiota_upregulated
      WBPaper00056169:rrf-3(pk1426)_upregulated_embryo
      WBPaper00056443:DietaryRestriction_upregulated
      WBPaper00056443:sek-1(km4)_upregulated
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated
      WBPaper00056826:hmc_biased
      WBPaper00057154:HeatShock_downregulated_miRNA-target
      WBPaper00057154:HeatShock_upregulated_mRNA
      WBPaper00057288:iff-1(RNAi)_upregulated_transcript
      WBPaper00058598:sin-3(tm1276)_downregulated
      WBPaper00058969:RIS_enriched
      WBPaper00059421:daf-1(m40);daf-3(mgDf90)_downregulated
      WBPaper00059421:daf-3(mgDf90)_downregulated
      WBPaper00059471:EGL-43_interacting
      WBPaper00059664:srbc-48(ac23)_upregulated
      WBPaper00059763:neuron_expressed
      WBPaper00060014:set-2(tm1630)_downregulated
      WBPaper00060445:nfki-1(cer1)_downregulated_L4
      WBPaper00060661:sensory-neuron_enriched
      WBPaper00060811:L1_vs_adult_upregulated_neural
      WBPaper00060909:atfs-1(cmh15)_downregulated
      WBPaper00061007:S.aquatilis_upregulated
      WBPaper00061203:let-418(n3536)_upregulated
      WBPaper00061203:sin-3(tm1276)_upregulated
      WBPaper00061203:spr-1(ok2144)_upregulated
      WBPaper00061340:ADF_AWB
      WBPaper00061340:AIN
      WBPaper00061340:AIY
      WBPaper00061340:AIZ
      WBPaper00061340:ALN
      WBPaper00061340:ASK_parent
      WBPaper00061340:AVA
      WBPaper00061340:AVK
      WBPaper00061340:Excretory_gland
      WBPaper00061340:Neuroblast_ADF_AWB
      WBPaper00061340:Parent_of_exc_gland_AVK
      WBPaper00061340:Pharyngeal_marginal_cell
      WBPaper00061340:RIC
      WBPaper00061340:RIC_parent
      WBPaper00061340:RID
      WBPaper00061340:RIM
      WBPaper00061340:RIM_parent
      WBPaper00061340:RIV
      WBPaper00061340:RMD
      WBPaper00061340:SIA
      WBPaper00061340:SMB
      WBPaper00061340:SMD
      WBPaper00061405:S.aureus_downregulated_starvation
      WBPaper00061439:unc-30(ok613)_upregulated_P.aeruginosa-infection
      WBPaper00061479:hda-1(ne4752)_upregulated
      WBPaper00061527:R07G3.8_9125-ric-4_17408
      WBPaper00061651:I1_enriched
      WBPaper00061651:MC_enriched
      WBPaper00061902:camt-1(ok515)_regulated_URX-AQR-PQR
      WBPaper00061995:mter-4(syb3662syb3403)_downregulated
      WBPaper00062159:hda-2(ok1479)_upregulated
      WBPaper00062184:PA14_downregulated
      WBPaper00062325:muscle_enriched_coding-RNA
      WBPaper00062440:crh-1(n3315)_downregulated
      WBPaper00062446:nhr-8(hd117)_upregulated
      WBPaper00062672:let-418(n3536)dcp-66(RNAi)_upregulated
      WBPaper00064088:Day-1-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-1-adult_vs_L4_downregulated_fem-3(q20)
      WBPaper00064088:Day-1-adult_vs_L4_downregulated_glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20)
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_glp-1(e2141)
      WBPaper00064306:Agaro-oligosaccharides_upregulated
      WBPaper00064505:tamoxifen_downregulated
      WBPaper00064721:fasn-1(g14)_downregulated_starved
      WBPaper00065096:25C_vs_20C_downregulated
      WBPaper00065096:Day10_vs_Day1_downregulated
      WBPaper00065258:anchor-cell_enriched
      WBPaper00065749:Heat-Shock_downregulated_endu-2(tm4977)
      WBPaper00065835:Day5_vs_Day1_downregulated
      WBPaper00065841:28_0
      WBPaper00065841:29_0
      WBPaper00065841:36_0
      WBPaper00065841:51_0
      WBPaper00065841:51_1
      WBPaper00065841:53_0
      WBPaper00065841:62_0
      WBPaper00065841:66_0
      WBPaper00065841:67_0
      WBPaper00065841:112_0
      WBPaper00065841:114_0
      WBPaper00065841:115_0
      WBPaper00065841:119_0
      WBPaper00065841:120_0
      WBPaper00065926:pgph-2(overepxreesion)_upregulated_glucose
      WBPaper00066062:xrep-4(lax137)_upregulated
      WBPaper00066085:sin-3(tm1276)_upregulated
      WBPaper00066110:Doxorubicin_upregulated_diploid
      WBPaper00066110:tetraploid_vs_diploid_upregulated
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00028789:PA14_vs_OP50_downregulated_8hr
      WBPaper00031003:hlh_1_enriched
      WBPaper00031252:AIN-1_IP_enriched
      WBPaper00034757:down_by_oxidative_stress
      WBPaper00035084:L1_enriched_AIN-2_IP
      WBPaper00035873:dpy-9_regulated
      WBPaper00035873:dpy-10_regulated
      WBPaper00036130:mir-243_up_regulated
      WBPaper00036286:Pattern_G
      WBPaper00038304:octr-1_regulated
      WBPaper00040210:Diazinon_24C_regulated
      WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2
      WBPaper00040858:eQTL_regulated_developing
      WBPaper00040963:Q100_down
      WBPaper00040963:Q200_down
      WBPaper00040963:TA300_up
      WBPaper00041002:HF_11d_0.2mM_Up
      WBPaper00041174:environmental
      WBPaper00041174:genotypic
      WBPaper00041174:genotypic_and_environmental
      WBPaper00041939:control_vs_EtBr-exposed_48h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_51h
      WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00041939:UVC-EtBr-exposed_vs_EtBr-exposed_51h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_51h
      WBPaper00042548:miRISC_enriched
      WBPaper00045673:colistin_upregulated
      WBPaper00045960:L4-lethargus_upregulated
      WBPaper00048989:N2_rapamycin_upregulated
      WBPaper00053236:Starvation_regulated_N2
    Interaction (17)
    Anatomy_function: WBbtf0219
    WBProcess: WBbiopr:00000120
  Map_info: Map: IV Position: 4.64008 Error: 0.000248
    Positive: Positive_clone: C43F9 Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4275
        5330
        4321
    Pseudo_map_position
  Reference (26)
  Remark: Sequence connection from [Wang X, Culotti JG, Pawson T]
    Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene