WormBase Tree Display for Gene: WBGene00001080
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WBGene00001080 | Evidence | Paper_evidence | WBPaper00006355 | ||||
---|---|---|---|---|---|---|---|
SMap | S_parent | Sequence | Y59A8B | ||||
Identity (6) | |||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | dpy | ||||||
Reference_allele | WBVar00143205 | ||||||
Allele (428) | |||||||
Legacy_information | e428 : weak dumpy (XX) non-dumpy (XO); lethal to 2A;3X. ES3 (adult) ES1 (larvae). ME3. NA3 (e459 (resembles e428) ct16 (very weak dumpy)). | ||||||
See also e428, e459, e1483 | |||||||
[C.elegansII] e428 : weak dumpy (XX); non-dumpy (XO); lethal to 2A;3X. ES3 (adult) ES1 (larvae).Some X chromosome transcript levels elevated,in both XX and XO. ME3. OA2: e459 (resembles e428), ct16 (very weak phenotype). [Hodgkin 1983b; Meyer and Casson 1986; TY] | |||||||
Strain (20) | |||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (12) | |||||||
Contained_in_operon | CEOP5552 | ||||||
Ortholog (36) | |||||||
Structured_description | Concise_description | dpy-21 encodes a novel, conserved protein with a proline-rich N terminus; dpy-21 affects RNA levels of X-linked dosage-compensated genes, body length in hermaphrodites, and fertility and male tail development in males; DPY-21 interacts in vivo with DPY-27 and SDC-3, members of the dosage compensation complex, and like members of the dosage compensation complex, is diffusely localized in nuclei of XX embryos containing <40 cells, but then specifically localizes to X chromosomes of XX embryos with >40 cells, remaining on the X throughout development; in XO embryos, DPY-21 is dispersed throughout the nucleus in multiple foci that are not coincident with the X chromosome; in hermaphrodites, localization of DPY-21 to the X chromosome requires activity of SDC-2, SDC-3, DPY-26, DPY-27, and DPY-28; DPY-21 is not, however, required reciprocally for the stability or localization of these other dosage compensation proteins; in addition, unlike SDC-3 and other members of the dosage compensation complex, DPY-21 is not recruited to the autosomal her-1 regulatory region, suggesting that DPY-21 is not part of the gene-specific complex that represses her-1 expression in hermaphrodites. | Paper_evidence | WBPaper00000665 | |||
WBPaper00000941 | |||||||
WBPaper00001003 | |||||||
WBPaper00006355 | |||||||
Curator_confirmed | WBPerson48 | ||||||
WBPerson1843 | |||||||
Date_last_updated | 17 Jul 2006 00:00:00 | ||||||
Automated_description | Enables histone H4K20 demethylase activity. Predicted to be involved in chromatin remodeling. Located in X chromosome. Is an ortholog of human RSBN1L (round spermatid basic protein 1 like). | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Molecular_info | Corresponding_CDS | Y59A8B.1a | |||||
Corresponding_CDS_history | Y59A8B.1:wp139 | ||||||
Corresponding_transcript | Y59A8B.1b | ||||||
Y59A8B.1a.1 | |||||||
Other_sequence (17) | |||||||
Associated_feature | WBsf653522 | ||||||
WBsf982072 | |||||||
WBsf1002778 | |||||||
WBsf1002779 | |||||||
WBsf014601 | |||||||
Experimental_info | RNAi_result (13) | ||||||
Expr_pattern | Expr2896 | ||||||
Expr13514 | |||||||
Expr1027959 | |||||||
Expr1030687 | |||||||
Expr1161165 | |||||||
Expr2011064 | |||||||
Expr2029301 | |||||||
Regulate_expr_cluster | WBPaper00050370:dpy-21(e428)_L3_downregulated | ||||||
WBPaper00050370:dpy-21(e428)_L3_upregulated | |||||||
WBPaper00050801:DPY-21_dauer_regulome | |||||||
Antibody | WBAntibody00000707 | ||||||
WBAntibody00000708 | |||||||
Microarray_results (20) | |||||||
Expression_cluster (115) | |||||||
Interaction (71) | |||||||
WBProcess | WBbiopr:00000056 | ||||||
Map_info | Map | V | Position | 13.3323 | Error | 0.006986 | |
Well_ordered | |||||||
Positive | Inside_rearr | ozDf1 | |||||
Positive_clone | Y59A8B | Inferred_automatically | From sequence, transcript, pseudogene data | ||||
Negative | Outside_rearr | ozDf2 | |||||
Mapping_data | 2_point (14) | ||||||
Multi_point (24) | |||||||
Pos_neg_data | 4305 | ||||||
4291 | |||||||
4292 | |||||||
4293 | |||||||
8970 | |||||||
8983 | |||||||
Landmark_gene | |||||||
Reference (124) | |||||||
Method | Gene |