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WormBase Tree Display for Gene: WBGene00000888

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Name Class

WBGene00000888SMapS_parentSequenceC34D4
IdentityVersion2
NameCGC_namecyn-12Person_evidenceWBPerson466
Sequence_nameC34D4.12
Molecular_nameC34D4.12a
C34D4.12a.1
CE17506
C34D4.12b
CE49222
C34D4.12b.1
Other_namecyp-12Person_evidenceWBPerson466
CELE_C34D4.12Accession_evidenceNDBBX284604
Public_namecyn-12
DB_infoDatabase (12)
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:21WBPerson1971EventImportedInitial conversion from geneace
220 Sep 2004 16:20:03WBPerson1971Name_changeCGC_namecyp-12 -> cyn-12
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classcyn
Allele (15)
Legacy_information[Page AP] C34D4.12. No mutants known. Transpliced to SL1 and SL2
RNASeq_FPKM (74)
GO_annotation00061263
00061264
00061265
00061266
00061267
00061268
00061269
00061270
00107948
00107949
Ortholog (37)
Paralog (18)
Structured_descriptionConcise_descriptioncyn-12 encodes a member of the cyclophilin family that is related to human PPIL1 (CGI-124); based upon its sequence similarity, CYN-12 is predicted to be a cytoplasmic protein potentially involved in a wide range of signal transduction pathways.Paper_evidenceWBPaper00026884
Curator_confirmedWBPerson48
WBPerson1843
Date_last_updated20 Mar 2007 00:00:00
Automated_descriptionPredicted to enable peptidyl-prolyl cis-trans isomerase activity. Predicted to be part of catalytic step 2 spliceosome. Human ortholog(s) of this gene implicated in pontocerebellar hypoplasia type 14. Is an ortholog of human PPIL1 (peptidylprolyl isomerase like 1).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoPotential_modelDOID:0112325Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:9260)
Molecular_infoCorresponding_CDSC34D4.12a
C34D4.12b
Corresponding_transcriptC34D4.12a.1
C34D4.12b.1
Other_sequence (54)
Associated_featureWBsf651890
WBsf230223
Experimental_infoRNAi_result (12)
Expr_patternExpr1011395
Expr1030553
Expr1145887
Expr2010664
Expr2028904
Drives_constructWBCnstr00037218
Construct_productWBCnstr00037218
Microarray_results (19)
Expression_clusterWBPaper00031040:TGF-beta_adult_downregulated
WBPaper00037950:AVE-neuron_L1-larva_expressed
WBPaper00037950:BAG-neuron_blastula-embryo_expressed
WBPaper00037950:bodywall-muscle_L1-larva_expressed
WBPaper00037950:bodywall-muscle_L2-larva_expressed
WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed
WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
WBPaper00037950:excretory-cell_L2-larva_expressed
WBPaper00037950:GABAergic-motor-neurons_L1-larva_expressed
WBPaper00037950:germline-precursors_blastula-embryo_expressed
WBPaper00037950:hypodermis_L3-L4-larva_expressed
WBPaper00037950:intestine_L1-larva_expressed
WBPaper00037950:intestine_L2-larva_expressed
WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
WBPaper00044426:rotenone_24h_upregulated
WBPaper00044656:tatn-1(qd182)_downregulated
WBPaper00044736:flat_dev_expression
WBPaper00044760:germline_specific
WBPaper00045521:Gender_Neutral
WBPaper00048785:heat-shock_downregulated
WBPaper00048923:Aging_regulated
WBPaper00048988:daf-2(e1370)_daf-16(mu86)_downregulated_neuron
WBPaper00048988:daf-2(e1370)_downregulated_neuron
WBPaper00048988:neuron_expressed
WBPaper00049498:npr-1(ur89)_regulated_3
WBPaper00049545:jmjd-3.1(+)_downregulated
WBPaper00049545:sur-5p-jmjd-1.2(+)_downregulated
WBPaper00049942:hsf-1(RNAi)_downregulated
WBPaper00050225:flp-6(RNAi)_downregulated
WBPaper00050344:AFD-neuron_enriched
WBPaper00050488:adult_vs_dauer_regulated_N2_20C
WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
WBPaper00050726:OsmoticStress_regulated_Food
WBPaper00050859:downregulated_P-granule(-)GFP(+)_vs_control_day2-adult
WBPaper00050990:arcade_intestinal-valve_expressed
WBPaper00050990:hypodermis_expressed
WBPaper00050990:intestine_expressed
WBPaper00050990:seam_expressed
WBPaper00051039:germline_enriched
WBPaper00051352:Long-Term-Association-Memory_upregulated
WBPaper00052884:emb-4(hc60)_downregulated
WBPaper00053713:Pheromone-induced_postdauer_vs_control_downregulated
WBPaper00053810:daf-2(e1370)_downregulated
WBPaper00053810:nuo-6(qm200)_downregulated
WBPaper00055354:Rapamycin-Psora-Allantoin_downregulated
WBPaper00055354:Rapamycin-Rifampicin-Psora_downregulated
WBPaper00055354:Rapamycin-Rifampicin_downregulated
WBPaper00055354:Rifampicin-Allantoin_upregulated
WBPaper00055354:Rifampicin-Psora_downregulated
WBPaper00055648:germline_expressed
WBPaper00055862:antimycin_damt-1(gk961032)_regulated
WBPaper00056471:aak-1(tm1944);aak-2(ok524)_downregulated
WBPaper00058598:mex-3(eu149)_downregulated
WBPaper00058598:sin-3(tm1276)_upregulated
WBPaper00058691:sin-3(tm1276)_downregulated
WBPaper00059328:mrps-5(RNAi)_downregulated_mRNA
WBPaper00059334:SACY-1_interacting
WBPaper00060014:set-2(tm1630)_upregulated
WBPaper00060100:SiNP_downregulated_mRNA
WBPaper00060661:hypoxia_downregulated
WBPaper00060661:sensory-neuron_depleted
WBPaper00060811:L1_vs_adult_downregulated_neural
WBPaper00061007:HB101_downregulated
WBPaper00061007:S.aquatilis_downregulated
WBPaper00061203:sin-3(tm1276)_downregulated
WBPaper00061274:hypergravity_10xg_upregulated
WBPaper00061340:Neuroblast_ALM_BDU
WBPaper00061527:pch-2-B0393.3
WBPaper00062159:hda-2(ok1479)_downregulated
WBPaper00062498:PPM-1.D_interacting
WBPaper00062669:extracellular-vesicle_protein
WBPaper00064071:NHR-49_interacting
WBPaper00064088:Day-1-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
WBPaper00064088:Day-1-adult_vs_L4_downregulated_glp-1(e2141)
WBPaper00064088:Day-3-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
WBPaper00064088:Day-3-adult_vs_L4_downregulated_glp-1(e2141)
WBPaper00064229:B.thuringiensis-Cry5Ba_downregulated
WBPaper00064716:paraquat_upregulated
WBPaper00065096:Day10_vs_Day1_upregulated
WBPaper00065373:Cisplatin_upregulated_WT
WBPaper00065373:sek-1(km4)_upregulated_cisplatin
WBPaper00065975:P-body_vs_WholeAnimal_enriched
WBPaper00065993:glp-1(e2141)_downregulated
WBPaper00066085:sin-3(syb2172)_downregulated
WBPaper00066146:germline-inx-14(RNAi)_downregulated_PA14
cgc4386_cluster_6_2
cgc4489_group_2
WBPaper00025141:N2_Expressed_Genes
WBPaper00025141:unc-4::GFP_Expressed_Genes
WBPaper00026929:sir-2.1_overexpression_regulated
WBPaper00026980:intestine_enriched
WBPaper00027342:alpha-Synuclein(WT)_upregulated
WBPaper00035479:daf-16(RNAi)_upregulated
WBPaper00035905:FBF-1_Associated
WBPaper00036286:Pattern_F
WBPaper00037901:GLD-1_mRNA_targets
WBPaper00040184:hcf-1nc_sir-2.1nc_daf-2down
WBPaper00040210:Chlorpyrifos_16C_regulated
WBPaper00040210:Chlorpyrifos_Diazinon_24C_regulated
WBPaper00041606:CE_X.nematophila_regulated
WBPaper00041939:control_vs_EtBr-exposed_48h
WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h
WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h
WBPaper00053236:Starvation_regulated_GR1307
WBPaper00053236:Starvation_regulated_N2
[cgc5767]:expression_class_M
[cgc5767]:expression_class_SM
[cgc6390]:Cluster_E
[cgc6390]:oogenesis-enriched
Interaction (56)
Map_infoMapIVPosition3.29058Error8.3e-05
PositivePositive_cloneC34D4Inferred_automaticallyFrom sequence, transcript, pseudogene data
Pseudo_map_position
ReferenceWBPaper00026884
WBPaper00038491
WBPaper00055090
RemarkThis gene has been renamed with approval of the CGC (cyp-12->cyn-12)Person_evidenceWBPerson466
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene