WormBase Tree Display for Gene: WBGene00000845
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WBGene00000845 | Evidence | Person_evidence | WBPerson170 | |||
---|---|---|---|---|---|---|
SMap | S_parent | Sequence | C02C2 | |||
Identity (6) | ||||||
Gene_info | Biotype | SO:0001217 | ||||
Gene_class | cup | |||||
Allele (34) | ||||||
Strain | WBStrain00031661 | |||||
RNASeq_FPKM (74) | ||||||
GO_annotation (31) | ||||||
Ortholog (29) | ||||||
Paralog (100) | ||||||
Structured_description | Concise_description | cup-4 encodes a non-alpha ligand-gated ion channel with similarity to the nicotinic acetylcholine receptors; cup-4 is required cell autonomously for efficient fluid endocytosis in coelomocytes; cup-4 mutant animals display reduced levels of plasma membrane phosphatidylinositol 4,5-bisphosphate, suggesting that CUP-4 may regulate endocytosis via regulation of phospholipase C activity; in addition, cup-4 mutants display disorganized clathrin and RME-1 at the coelomocyte plasma membrane; CUP-4::GFP is expressed in coelomocytes where it localizes to the cytoplasm, primarily to cytoplasmic vesicles. | Paper_evidence | WBPaper00004883 | ||
WBPaper00006324 | ||||||
WBPaper00025238 | ||||||
Curator_confirmed | WBPerson1843 | |||||
WBPerson567 | ||||||
Date_last_updated | 01 Sep 2010 00:00:00 | |||||
Automated_description | Predicted to enable neurotransmitter receptor activity. Involved in several processes, including determination of adult lifespan; positive regulation of egg-laying behavior; and response to caloric restriction. Located in cytoplasmic vesicle membrane. | Paper_evidence | WBPaper00065943 | |||
Curator_confirmed | WBPerson324 | |||||
WBPerson37462 | ||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | |||||
Date_last_updated | 29 Nov 2023 00:00:00 | |||||
Molecular_info | Corresponding_CDS | C02C2.3 | ||||
Corresponding_transcript | C02C2.3.1 | |||||
Other_sequence | JO468316.1 | |||||
JI169898.1 | ||||||
Oden_isotig23439 | ||||||
Associated_feature | WBsf645364 | |||||
WBsf225290 | ||||||
Experimental_info | RNAi_result (14) | |||||
Expr_pattern | Expr3280 | |||||
Expr16469 | ||||||
Expr1011461 | ||||||
Expr1030524 | ||||||
Expr1143520 | ||||||
Expr1200314 | ||||||
Expr2010596 | ||||||
Expr2028836 | ||||||
Drives_construct | WBCnstr00005671 | |||||
WBCnstr00005672 | ||||||
WBCnstr00011282 | ||||||
WBCnstr00037250 | ||||||
Construct_product | WBCnstr00007433 | |||||
WBCnstr00011282 | ||||||
WBCnstr00037250 | ||||||
Microarray_results (20) | ||||||
Expression_cluster (119) | ||||||
Interaction | WBInteraction000051699 | |||||
WBInteraction000390325 | ||||||
WBInteraction000421321 | ||||||
WBInteraction000585701 | ||||||
Map_info (3) | ||||||
Reference (13) | ||||||
Remark | pJF148 is identified as positive via stable transformation rescue, ar494 mutation, RNAi | Person_evidence | WBPerson170 | |||
Method | Gene |