WormBase Tree Display for Gene: WBGene00000845
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WBGene00000845 | Evidence | Person_evidence | WBPerson170 | ||||
---|---|---|---|---|---|---|---|
SMap | S_parent | Sequence | C02C2 | ||||
Identity (6) | |||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | cup | ||||||
Allele (34) | |||||||
Strain | WBStrain00031661 | ||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (31) | |||||||
Ortholog (29) | |||||||
Paralog (100) | |||||||
Structured_description | Concise_description | cup-4 encodes a non-alpha ligand-gated ion channel with similarity to the nicotinic acetylcholine receptors; cup-4 is required cell autonomously for efficient fluid endocytosis in coelomocytes; cup-4 mutant animals display reduced levels of plasma membrane phosphatidylinositol 4,5-bisphosphate, suggesting that CUP-4 may regulate endocytosis via regulation of phospholipase C activity; in addition, cup-4 mutants display disorganized clathrin and RME-1 at the coelomocyte plasma membrane; CUP-4::GFP is expressed in coelomocytes where it localizes to the cytoplasm, primarily to cytoplasmic vesicles. | Paper_evidence | WBPaper00004883 | |||
WBPaper00006324 | |||||||
WBPaper00025238 | |||||||
Curator_confirmed | WBPerson1843 | ||||||
WBPerson567 | |||||||
Date_last_updated | 01 Sep 2010 00:00:00 | ||||||
Automated_description | Predicted to enable neurotransmitter receptor activity. Involved in several processes, including determination of adult lifespan; positive regulation of egg-laying behavior; and response to caloric restriction. Located in cytoplasmic vesicle membrane. | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Molecular_info | Corresponding_CDS | C02C2.3 | |||||
Corresponding_transcript | C02C2.3.1 | ||||||
Other_sequence | JO468316.1 | ||||||
JI169898.1 | |||||||
Oden_isotig23439 | |||||||
Associated_feature | WBsf645364 | ||||||
WBsf225290 | |||||||
Experimental_info | RNAi_result (14) | ||||||
Expr_pattern | Expr3280 | ||||||
Expr16469 | |||||||
Expr1011461 | |||||||
Expr1030524 | |||||||
Expr1143520 | |||||||
Expr1200314 | |||||||
Expr2010596 | |||||||
Expr2028836 | |||||||
Drives_construct (4) | |||||||
Construct_product | WBCnstr00007433 | ||||||
WBCnstr00011282 | |||||||
WBCnstr00037250 | |||||||
Microarray_results (20) | |||||||
Expression_cluster (119) | |||||||
Interaction | WBInteraction000051699 | ||||||
WBInteraction000390325 | |||||||
WBInteraction000421321 | |||||||
WBInteraction000585701 | |||||||
Map_info | Map | III | Position | -0.533135 | Error | 0.003482 | |
Positive | Positive_clone | C02C2 | Inferred_automatically | From sequence, transcript, pseudogene data | |||
pJF148 | Person_evidence | WBPerson170 | |||||
Mapping_data | Multi_point | 3952 | |||||
5055 | |||||||
Reference (13) | |||||||
Remark | pJF148 is identified as positive via stable transformation rescue, ar494 mutation, RNAi | Person_evidence | WBPerson170 | ||||
Method | Gene |