WormBase Tree Display for Gene: WBGene00000840

WBGene00000840 SMap: S_parent: Sequence: ZK856
  Identity: Version: 1
    Name: CGC_name: cul-5 Person_evidence: WBPerson1052
      Sequence_name: ZK856.1
      Molecular_name: ZK856.1
        ZK856.1.1
        CE41096
      Other_name: CELE_ZK856.1 Accession_evidence: NDB BX284605
      Public_name: cul-5
    DB_info: Database: AceView gene 5K663
        WormQTL gene WBGene00000840
        WormFlux gene WBGene00000840
        NDB locus_tag CELE_ZK856.1
        Panther gene CAEEL|WormBase=WBGene00000840|UniProtKB=Q23639
          family PTHR11932
        NCBI gene 179413
        RefSeq protein NM_073215.8
        SwissProt UniProtAcc Q23639
        TREEFAM TREEFAM_ID TF105874
        UniProt_GCRP UniProtAcc Q23639
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:21 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: cul
    Allele (48)
    Strain: WBStrain00001851
      WBStrain00032168
    RNASeq_FPKM (74)
    GO_annotation: 00079158
      00079159
      00079160
      00079161
      00079162
      00079163
      00079164
      00107887
      00107888
    Contained_in_operon: CEOP5246
    Ortholog (39)
    Paralog: WBGene00000836 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00000837 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00000838 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00000839 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00000841 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00000143 Caenorhabditis elegans From_analysis: WormBase-Compara
    Structured_description: Concise_description: cul-5 encodes a cullin, orthologous to vasopressin-activated calcium-mobilizing receptor-1 in mammals, that is thought to regulate the cell cycle by virtue of its paralogy to cul-1 and cul-2; however, CUL-5 is dispensable for viability and gross morphology in mass RNAi screens, and does not appear to interact with any of 17 Skp1-related proteins (SKR-1 through SKR-21). Paper_evidence: WBPaper00002473
            WBPaper00005128
            WBPaper00005654
          Curator_confirmed: WBPerson567
          Date_last_updated: 17 Jun 2004 00:00:00
      Automated_description: Predicted to enable protein-macromolecule adaptor activity and ubiquitin protein ligase binding activity. Predicted to be involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process and protein ubiquitination. Predicted to be part of Cul5-RING ubiquitin ligase complex and SCF ubiquitin ligase complex. Expressed in several structures, including head; intestine; nervous system; tail; and vulval muscle. Is an ortholog of human CUL5 (cullin 5). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: ZK856.1
    Corresponding_CDS_history: ZK856.1:wp175
    Corresponding_transcript: ZK856.1.1
    Other_sequence (34)
    Associated_feature: WBsf647140
      WBsf661616
      WBsf1001071
  Experimental_info: RNAi_result (20)
    Expr_pattern: Chronogram1562
      Expr7264
      Expr8294
      Expr1024104
      Expr1030522
      Expr1163196
      Expr2010590
      Expr2028830
    Drives_construct: WBCnstr00002643
      WBCnstr00037253
    Construct_product: WBCnstr00037253
    Microarray_results (18)
    Expression_cluster: WBPaper00031040:TGF-beta_adult_downregulated
      WBPaper00033065:cyc-1(RNAi)_downregulated
      WBPaper00037950:A-class-motor-neurons_L2-larva_expressed
      WBPaper00037950:all-neurons_embryo_enriched
      WBPaper00037950:all-neurons_L1-larva_expressed
      WBPaper00037950:all-neurons_L2-larva_expressed
      WBPaper00037950:AVA-neuron_L1-larva_expressed
      WBPaper00037950:BAG-neuron_blastula-embryo_expressed
      WBPaper00037950:bodywall-muscle_L2-larva_expressed
      WBPaper00037950:dopaminergic-neurons_L1-larva_expressed
      WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
      WBPaper00037950:excretory-cell_L2-larva_expressed
      WBPaper00037950:GABAergic-motor-neurons_L1-larva_expressed
      WBPaper00037950:germline-precursors_blastula-embryo_expressed
      WBPaper00037950:hypodermis_L3-L4-larva_expressed
      WBPaper00037950:intestine_L1-larva_expressed
      WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
      WBPaper00044656:tatn-1(qd182)_downregulated
      WBPaper00044736:flat_dev_expression
      WBPaper00045521:Oogenic
      WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h
      WBPaper00048988:neuron_expressed
      WBPaper00049290:rsks-1(sv31)_downregulated
      WBPaper00049545:jmjd-3.1(+)_upregulated
      WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated
      WBPaper00049545:sur-5p-jmjd-1.2(+)_upregulated
      WBPaper00049920:Glucose-Diet_downregulated_hyl-2(tm2031)
      WBPaper00049920:Glucose-Diet_downregulated_N2
      WBPaper00049942:HeatShock_downregulated_hsf-1(+)
      WBPaper00050344:AFD-neuron_enriched
      WBPaper00050344:PLM-neuron_enriched
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
      WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C
      WBPaper00050859:downregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050990:body-muscle_expressed
      WBPaper00050990:GABAergic-neuron_expressed
      WBPaper00050990:hypodermis_expressed
      WBPaper00050990:intestine_expressed
      WBPaper00051039:germline_enriched
      WBPaper00051245:epidermis_cytoplasm_expressed
      WBPaper00051245:intestine_cytoplasm_expressed
      WBPaper00052885:hrde-1(tm1200)-emb-4(qm31)_regulated
      WBPaper00053020:sta-1(ok587)_downregulated
      WBPaper00053184:sma-2(rax5)_downregulated
      WBPaper00053184:sma-4(rax3)_downregulated
      WBPaper00053302:stavudine_24h_regulated
      WBPaper00053302:zidovudine_72h_regulated
      WBPaper00053810:daf-2(e1370)_downregulated
      WBPaper00053810:isp-1(qm150)_downregulated
      WBPaper00053814:25C_downregulated_OP50
      WBPaper00055226:ADR-2_target_N2
      WBPaper00055334:DLC-1_interacting
      WBPaper00055565:AVK_enriched
      WBPaper00055648:germline_expressed
      WBPaper00055897:heat-shock_downregulated
      WBPaper00055971:nhl-2(ok818)_25C_upregulated
      WBPaper00056034:pals-22(jy3)_downregulated
      WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047)
      WBPaper00056139:soil-microbiota_downregulated
      WBPaper00056443:sek-1(km4)_downregulated
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_downregulated
      WBPaper00058691:cfp-1(tm6369)_downregulated
      WBPaper00058691:set-2(bn129)_downregulated
      WBPaper00059356:BAZ-2_SET-6_interacting
      WBPaper00059471:EGL-43_interacting
      WBPaper00059567:olrn-1(ums9)_regulated
      WBPaper00060811:L1_vs_adult_upregulated_neural
      WBPaper00061040:eat-2(ad1116)_downregulated
      WBPaper00061439:unc-30(ok613)_downregulated
      WBPaper00061527:clr-1_21440-mtm-3_16030
      WBPaper00062193:hsf-1(RNAi)_downregulated
      WBPaper00062193:skn-1(RNAi)_downregulated
      WBPaper00062293:clk-1(qm30)_upregulated
      WBPaper00062293:isp-1(qm150)_upregulated
      WBPaper00062554:MAGU-2_interacting
      WBPaper00064071:NHR-49_interacting
      WBPaper00064088:Day-1-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064716:paraquat_upregulated
      WBPaper00065096:Day10_vs_Day1_upregulated
      WBPaper00065373:sek-1(km4)_downregulated_Ref
      WBPaper00065841:120_0
      WBPaper00065993:glp-1(e2141)_downregulated
      WBPaper00066062:xrep-4(lax137)_upregulated
      WBPaper00066085:sin-3(syb2172)_downregulated
      WBPaper00066146:germline-inx-14(RNAi)_downregulated_PA14
      cgc4386_cluster_5_1
      WBPaper00024671:AFD_AWB_vs_unsorted_upregulated
      WBPaper00025032:cluster_119
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00025141:unc-4::GFP_Expressed_Genes
      WBPaper00026929:sir-2.1_overexpression_regulated
      WBPaper00035588:alg-1(-)_upregulated
      WBPaper00035905:FBF-1_Associated
      WBPaper00037113:Chlorpyrifos_Diazinon_16C_regulated
      WBPaper00040184:hcf-1nc_sir-2.1nc_daf-2down
      WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2
      WBPaper00041002:HF_3d_2.0mM_Down
      WBPaper00041606:CE_S.marcescens_regulated
      WBPaper00041606:CE_X.nematophila_regulated
      WBPaper00041906:I-3690_vs_OP50_3d
      WBPaper00045263:isp-1(qm150)_downregulated
      WBPaper00048989:N2_rapamycin_downregulated
      WBPaper00053688:E.faecium_upregulated
      WBPaper00053827:pyoverdine_upregulated
      WBPaper00057098:SiO2-nanoparticles_upregulated
      [cgc5767]:expression_class_E
      [cgc5767]:expression_class_E_pi(23_min)
      [cgc5767]:expression_class_M
      [cgc5767]:expression_class_ME
      [cgc6390]:Cluster_E
      [cgc6390]:mixed_oogenesis-somatic
    Interaction (34)
  Map_info: Map: V Position: 2.30976 Error: 0.009953
    Positive: Positive_clone: ZK856 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 5581
    Pseudo_map_position
  Reference (13)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene