WormBase Tree Display for Gene: WBGene00000143
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| WBGene00000143 | SMap | S_parent | Sequence | K06H7 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | apc-2 | Person_evidence | WBPerson205 | |||||
| Sequence_name | K06H7.6 | ||||||||
| Molecular_name | K06H7.6 | ||||||||
| K06H7.6.1 | |||||||||
| CE41679 | |||||||||
| Other_name | CELE_K06H7.6 | Accession_evidence | NDB | BX284603 | |||||
| Public_name | apc-2 | ||||||||
| DB_info | Database | AceView | gene | 3J171 | |||||
| WormQTL | gene | WBGene00000143 | |||||||
| WormFlux | gene | WBGene00000143 | |||||||
| NDB | locus_tag | CELE_K06H7.6 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00000143|UniProtKB=P34514 | |||||||
| family | PTHR45957 | ||||||||
| NCBI | gene | 176139 | |||||||
| RefSeq | protein | NM_066361.7 | |||||||
| SwissProt | UniProtAcc | P34514 | |||||||
| TREEFAM | TREEFAM_ID | TF105442 | |||||||
| UniProt_GCRP | UniProtAcc | P34514 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:20 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | apc | ||||||||
| Allele (32) | |||||||||
| Strain | WBStrain00036412 | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (11) | |||||||||
| Ortholog (35) | |||||||||
| Paralog | WBGene00000836 | Caenorhabditis elegans | From_analysis | WormBase-Compara | |||||
| WBGene00000837 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00000838 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00000839 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00000840 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00000841 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| Structured_description | Concise_description | apc-2 encodes an ortholog of subunit 2 of anaphase-promoting complex (APC,a cyclin-specific E3 RING ubiquitin ligase); APC-2 and S. cerevisiae'sApc2p have 32% identity in their cullin domains (considered crucial forfunction), but otherwise share no obvious similarity; inactivating apc-2with RNAi causes embryos to arrest at the meiotic one-cell stage, implyingthat APC-2 is required for the metaphase-to-anaphase transition of meiosisI; this RNAi phenotype of apc-2 is shared by apc-1, apc-4, apc-11, cdc-16,cdc-23, and cdc-27; by analogy with other APC subunits with hypomorphicalleles, APC-2 is likely to be required for asymmetrical segregation ofcell fate determinants in two-cell embryos. | Paper_evidence | WBPaper00005096 | |||||
| WBPaper00013611 | |||||||||
| WBPaper00027095 | |||||||||
| WBPaper00028289 | |||||||||
| Curator_confirmed | WBPerson567 | ||||||||
| Date_last_updated | 09 Aug 2006 00:00:00 | ||||||||
| Automated_description | Predicted to enable ubiquitin protein ligase binding activity. Predicted to be involved in metaphase/anaphase transition of mitotic cell cycle and protein K11-linked ubiquitination. Predicted to be part of anaphase-promoting complex. Human ortholog(s) of this gene implicated in several diseases, including acute myeloid leukemia; lung disease (multiple); and primary angle-closure glaucoma. Is an ortholog of human ANAPC2 (anaphase promoting complex subunit 2). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:5386 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:19989) | ||||
| DOID:3910 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:19989) | ||||||
| DOID:12449 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:19989) | ||||||
| DOID:1405 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:19989) | ||||||
| DOID:9119 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:19989) | ||||||
| Molecular_info | Corresponding_CDS | K06H7.6 | |||||||
| Corresponding_CDS_history | K06H7.6:wp183 | ||||||||
| Corresponding_transcript | K06H7.6.1 | ||||||||
| Other_sequence (18) | |||||||||
| Associated_feature | WBsf645383 | ||||||||
| WBsf645384 | |||||||||
| WBsf659223 | |||||||||
| WBsf225339 | |||||||||
| Experimental_info | RNAi_result (16) | ||||||||
| Expr_pattern | Expr1017011 | ||||||||
| Expr1030075 | |||||||||
| Expr1153776 | |||||||||
| Expr2009354 | |||||||||
| Expr2027590 | |||||||||
| Drives_construct | WBCnstr00037708 | ||||||||
| Construct_product | WBCnstr00037708 | ||||||||
| Microarray_results (22) | |||||||||
| Expression_cluster (116) | |||||||||
| Interaction (218) | |||||||||
| Map_info | Map | III | Position | -0.383689 | Error | 0.000955 | |||
| Positive | Positive_clone | K06H7 | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Pseudo_map_position | |||||||||
| Reference | WBPaper00031064 | ||||||||
| WBPaper00035228 | |||||||||
| WBPaper00038491 | |||||||||
| WBPaper00055090 | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
