WormBase Tree Display for Gene: WBGene00000832
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| WBGene00000832 | SMap | S_parent | Sequence | Y23H5A | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | ctn-1 | Person_evidence | WBPerson481 | |||||
| Sequence_name | Y23H5A.5 | ||||||||
| Molecular_name (12) | |||||||||
| Other_name | Y23H5A.c | Curator_confirmed | WBPerson1983 | ||||||
| Remark | Old cosmid naming mapped via unique overlapping PCR_product on CDSs | ||||||||
| CELE_Y23H5A.5 | Accession_evidence | NDB | BX284601 | ||||||
| Public_name | ctn-1 | ||||||||
| DB_info | Database (12) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:21 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | ctn | ||||||||
| Allele (245) | |||||||||
| Strain | WBStrain00037343 | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation | 00021143 | ||||||||
| 00021144 | |||||||||
| 00021145 | |||||||||
| 00021146 | |||||||||
| 00021147 | |||||||||
| 00021148 | |||||||||
| 00107861 | |||||||||
| 00107862 | |||||||||
| 00107863 | |||||||||
| 00107864 | |||||||||
| Ortholog (35) | |||||||||
| Paralog | WBGene00000942 | Caenorhabditis elegans | From_analysis | TreeFam | |||||
| WormBase-Compara | |||||||||
| WBGene00001978 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | ctn-1 encodes a protein that belongs to the alpha-catulin family of catenin-like proteins; CTN-1 physically interacts in vivo with DYB-1/dystrobrevin; a ctn-1::GFP fusion is expressed in body wall, vulval, and anal muscles; in body wall muscles, CTN-1::GFP localizes to the plasma membranes near dense bodies. | Paper_evidence | WBPaper00011358 | |||||
| WBPaper00041089 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson324 | |||||||||
| Date_last_updated | 02 Aug 2012 00:00:00 | ||||||||
| Automated_description | Predicted to enable actin filament binding activity and cadherin binding activity. Involved in regulation of locomotion. Located in plasma membrane and striated muscle dense body. Expressed in body wall musculature; non-striated muscle; and somatic nervous system. Used to study Duchenne muscular dystrophy. Is an ortholog of human CTNNAL1 (catenin alpha like 1). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Experimental_model | DOID:11723 | Homo sapiens | Paper_evidence | WBPaper00037625 | ||||
| Accession_evidence | OMIM | 310200 | |||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 22 May 2017 00:00:00 | ||||||||
| Disease_relevance | Mutations in human dystrophin are associated with the Duchenne and Becker types of muscular dystrophy, that affect skeletal muscles used for movement, and heart (cardiac) muscle; a number of transmembrane and peripheral membrane proteins interact with dystrophin to form the dystrophin-associated protein complex (DAPC); defects in components of the DAPC are associated with a variety of pathological conditions, including muscular dystrophy, cardiomyopathy, myoclonic dystonia, and vasospasm; in C. elegans, the DAPC localizes near dense bodies, structures that are analogous to muscle costameres; ctn-1, an ortholog of alpha catulin (catenin-like protein), interacts with dyb-1/dystrobrevin, and this interaction is required for the normal localization of the DAPC as well as for the slo-1 voltage- and calcium-activated potassium (BK) channel, in C. elegans muscle; in the dystrophic mdx mice, there is compensatory increase of alpha-catulin expression in the skeletal muscle where the DAPC is disassembled, and the mechanical link between the muscle costamere and the sarcolemma is lost. | Homo sapiens | Paper_evidence | WBPaper00037625 | |||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 22 May 2017 00:00:00 | ||||||||
| Models_disease_asserted | WBDOannot00000293 | ||||||||
| Molecular_info | Corresponding_CDS | Y23H5A.5a | |||||||
| Y23H5A.5c | |||||||||
| Y23H5A.5d | |||||||||
| Corresponding_CDS_history | Y23H5A.5a:wp274 | ||||||||
| Y23H5A.5b:wp274 | |||||||||
| Y23H5A.5c:wp228 | |||||||||
| Y23H5A.5d:wp210 | |||||||||
| Y23H5A.5d:wp228 | |||||||||
| Corresponding_transcript | Y23H5A.5e | ||||||||
| Y23H5A.5a.1 | |||||||||
| Y23H5A.5c.1 | |||||||||
| Y23H5A.5d.1 | |||||||||
| Y23H5A.5d.2 | |||||||||
| Y23H5A.5d.3 | |||||||||
| Other_sequence (47) | |||||||||
| Associated_feature | WBsf982915 | ||||||||
| WBsf982916 | |||||||||
| WBsf1009363 | |||||||||
| WBsf217315 | |||||||||
| WBsf217316 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00002350 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00055702 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00055701 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00116607 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00004565 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00022472 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00036720 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern (11) | |||||||||
| Drives_construct | WBCnstr00008299 | ||||||||
| WBCnstr00008300 | |||||||||
| WBCnstr00013721 | |||||||||
| WBCnstr00013723 | |||||||||
| WBCnstr00018330 | |||||||||
| WBCnstr00037258 | |||||||||
| Construct_product | WBCnstr00008299 | ||||||||
| WBCnstr00008300 | |||||||||
| WBCnstr00008301 | |||||||||
| WBCnstr00008302 | |||||||||
| WBCnstr00013723 | |||||||||
| WBCnstr00013724 | |||||||||
| WBCnstr00018330 | |||||||||
| WBCnstr00020433 | |||||||||
| WBCnstr00037258 | |||||||||
| Microarray_results (51) | |||||||||
| Expression_cluster (177) | |||||||||
| Interaction (29) | |||||||||
| Map_info | Map | I | Position | -8.18787 | Error | 0.026165 | |||
| Positive | Positive_clone | Y23H5A | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Pseudo_map_position | |||||||||
| Reference | WBPaper00011358 | ||||||||
| WBPaper00036762 | |||||||||
| WBPaper00037625 | |||||||||
| WBPaper00038491 | |||||||||
| WBPaper00039233 | |||||||||
| WBPaper00041089 | |||||||||
| WBPaper00043421 | |||||||||
| WBPaper00046703 | |||||||||
| WBPaper00055090 | |||||||||
| WBPaper00065040 | |||||||||
| Remark | Sequence connection from [Broadbent ID], 02/06/12 krb. | ||||||||
| Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
| Method | Gene |
