WormBase Tree Display for Gene: WBGene00000817
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| WBGene00000817 | SMap | S_parent | Sequence | B0547 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | csn-5 | Person_evidence | WBPerson57 | |||||
| Sequence_name | B0547.1 | ||||||||
| Molecular_name | B0547.1 | ||||||||
| B0547.1.1 | |||||||||
| CE06722 | |||||||||
| Other_name | CELE_B0547.1 | Accession_evidence | NDB | BX284604 | |||||
| Public_name | csn-5 | ||||||||
| DB_info | Database (12) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:21 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | csn | ||||||||
| Allele (25) | |||||||||
| Strain | WBStrain00001355 | ||||||||
| WBStrain00036128 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (33) | |||||||||
| Ortholog (38) | |||||||||
| Paralog | WBGene00001231 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WormBase-Compara | |||||||||
| WBGene00018135 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00004467 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | csn-5 encodes an ortholog of subunit 5 of the COP9 signalosome complex (CSN5), which in turn is a pan-eukaryotic multiprotein complex that positively regulates E3 ubiquitin ligases, physically interacts with SCF-type E3 ubiquitin ligases, and probably regulates protein degradation; CSN-5 (along with KGB-1 and ZYX-1) physically binds germline RNA helicases (GLH proteins), and csn-5(RNAi) results in sterile worms with small gonads and no oocytes, causing oogenesis to cease, but not affecting the initial assembly of P granules -- a defect essentially identical to that produced by RNAi with a combination of glh-1 and glh-4. | Paper_evidence | WBPaper00004651 | |||||
| WBPaper00005583 | |||||||||
| WBPaper00012892 | |||||||||
| WBPaper00013120 | |||||||||
| Curator_confirmed | WBPerson567 | ||||||||
| Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
| Automated_description | Enables DEAD/H-box RNA helicase binding activity. Involved in gonad development; oogenesis; and protein deneddylation. Located in A band and nucleus. Expressed in tail. Human ortholog(s) of this gene implicated in hepatocellular carcinoma. Is an ortholog of human COPS5 (COP9 signalosome subunit 5). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:684 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2240) | ||||
| Molecular_info | Corresponding_CDS | B0547.1 | |||||||
| Corresponding_transcript | B0547.1.1 | ||||||||
| Other_sequence (62) | |||||||||
| Associated_feature | WBsf645978 | ||||||||
| WBsf228325 | |||||||||
| Experimental_info | RNAi_result (34) | ||||||||
| Expr_pattern | Chronogram16 | ||||||||
| Expr2600 | |||||||||
| Expr5086 | |||||||||
| Expr8994 | |||||||||
| Expr11941 | |||||||||
| Expr1029217 | |||||||||
| Expr1030508 | |||||||||
| Expr1143331 | |||||||||
| Expr2010554 | |||||||||
| Expr2028794 | |||||||||
| Drives_construct | WBCnstr00002247 | ||||||||
| WBCnstr00002248 | |||||||||
| WBCnstr00037262 | |||||||||
| Construct_product | WBCnstr00037262 | ||||||||
| Regulate_expr_cluster | WBPaper00029237:CSN-5_interacting | ||||||||
| Antibody | WBAntibody00000577 | ||||||||
| WBAntibody00000628 | |||||||||
| WBAntibody00001976 | |||||||||
| Microarray_results (23) | |||||||||
| Expression_cluster (115) | |||||||||
| Interaction (186) | |||||||||
| Map_info | Map | IV | Position | 2.0216 | Error | 0.006342 | |||
| Positive | Positive_clone | B0547 | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Pseudo_map_position | |||||||||
| Reference (20) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
