WormBase Tree Display for Gene: WBGene00000817

WBGene00000817 SMap: S_parent: Sequence: B0547
  Identity: Version: 1
    Name: CGC_name: csn-5 Person_evidence: WBPerson57
      Sequence_name: B0547.1
      Molecular_name: B0547.1
        B0547.1.1
        CE06722
      Other_name: CELE_B0547.1 Accession_evidence: NDB BX284604
      Public_name: csn-5
    DB_info: Database (12)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:21 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: csn
    Allele (25)
    Strain: WBStrain00001355
      WBStrain00036128
    RNASeq_FPKM (74)
    GO_annotation (33)
    Ortholog (38)
    Paralog: WBGene00001231 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00018135 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00004467 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
    Structured_description: Concise_description: csn-5 encodes an ortholog of subunit 5 of the COP9 signalosome complex (CSN5), which in turn is a pan-eukaryotic multiprotein complex that positively regulates E3 ubiquitin ligases, physically interacts with SCF-type E3 ubiquitin ligases, and probably regulates protein degradation; CSN-5 (along with KGB-1 and ZYX-1) physically binds germline RNA helicases (GLH proteins), and csn-5(RNAi) results in sterile worms with small gonads and no oocytes, causing oogenesis to cease, but not affecting the initial assembly of P granules -- a defect essentially identical to that produced by RNAi with a combination of glh-1 and glh-4. Paper_evidence: WBPaper00004651
            WBPaper00005583
            WBPaper00012892
            WBPaper00013120
          Curator_confirmed: WBPerson567
          Date_last_updated: 17 Jun 2004 00:00:00
      Automated_description: Enables DEAD/H-box RNA helicase binding activity. Involved in gonad development; oogenesis; and protein deneddylation. Located in A band and nucleus. Expressed in tail. Human ortholog(s) of this gene implicated in hepatocellular carcinoma. Is an ortholog of human COPS5 (COP9 signalosome subunit 5). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:684 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:2240)
  Molecular_info: Corresponding_CDS: B0547.1
    Corresponding_transcript: B0547.1.1
    Other_sequence (62)
    Associated_feature: WBsf645978
      WBsf228325
  Experimental_info: RNAi_result (34)
    Expr_pattern: Chronogram16
      Expr2600
      Expr5086
      Expr8994
      Expr11941
      Expr1029217
      Expr1030508
      Expr1143331
      Expr2010554
      Expr2028794
    Drives_construct: WBCnstr00002247
      WBCnstr00002248
      WBCnstr00037262
    Construct_product: WBCnstr00037262
    Regulate_expr_cluster: WBPaper00029237:CSN-5_interacting
    Antibody: WBAntibody00000577
      WBAntibody00000628
      WBAntibody00001976
    Microarray_results (23)
    Expression_cluster (115)
    Interaction: WBInteraction000008272
      WBInteraction000008273
      WBInteraction000008274
      WBInteraction000008275
      WBInteraction000009670
      WBInteraction000009733
      WBInteraction000009894
      WBInteraction000009936
      WBInteraction000028294
      WBInteraction000028634
      WBInteraction000028876
      WBInteraction000028887
      WBInteraction000029476
      WBInteraction000030193
      WBInteraction000030194
      WBInteraction000030195
      WBInteraction000030196
      WBInteraction000032665
      WBInteraction000033228
      WBInteraction000033338
      WBInteraction000033578
      WBInteraction000034335
      WBInteraction000034536
      WBInteraction000035298
      WBInteraction000036025
      WBInteraction000036643
      WBInteraction000037427
      WBInteraction000039542
      WBInteraction000045749
      WBInteraction000048028
      WBInteraction000048029
      WBInteraction000048682
      WBInteraction000052963
      WBInteraction000105603
      WBInteraction000119950
      WBInteraction000133982
      WBInteraction000135512
      WBInteraction000136811
      WBInteraction000136812
      WBInteraction000148314
      WBInteraction000157932
      WBInteraction000157933
      WBInteraction000157934
      WBInteraction000157935
      WBInteraction000157936
      WBInteraction000157937
      WBInteraction000162272
      WBInteraction000165376
      WBInteraction000169115
      WBInteraction000169116
      WBInteraction000173001
      WBInteraction000173007
      WBInteraction000173008
      WBInteraction000173009
      WBInteraction000173010
      WBInteraction000183113
      WBInteraction000192155
      WBInteraction000195057
      WBInteraction000198193
      WBInteraction000200296
      WBInteraction000217900
      WBInteraction000217901
      WBInteraction000217902
      WBInteraction000232391
      WBInteraction000248375
      WBInteraction000254317
      WBInteraction000263389
      WBInteraction000264815
      WBInteraction000264838
      WBInteraction000264839
      WBInteraction000264840
      WBInteraction000264841
      WBInteraction000268000
      WBInteraction000275065
      WBInteraction000276635
      WBInteraction000283115
      WBInteraction000301747
      WBInteraction000328060
      WBInteraction000329483
      WBInteraction000336208
      WBInteraction000339654
      WBInteraction000368979
      WBInteraction000384291
      WBInteraction000392300
      WBInteraction000397569
      WBInteraction000405968
      WBInteraction000428196
      WBInteraction000437176
      WBInteraction000441192
      WBInteraction000442664
      WBInteraction000456683
      WBInteraction000500980
      WBInteraction000500981
      WBInteraction000503006
      WBInteraction000504467
      WBInteraction000505643
      WBInteraction000511449
      WBInteraction000511841
      WBInteraction000512431
      WBInteraction000512560
      WBInteraction000513511
      WBInteraction000513573
      WBInteraction000513699
      WBInteraction000513756
      WBInteraction000513888
      WBInteraction000513907
      WBInteraction000513921
      WBInteraction000516314
      WBInteraction000516441
      WBInteraction000517066
      WBInteraction000517414
      WBInteraction000518080
      WBInteraction000518122
      WBInteraction000518170
      WBInteraction000518200
      WBInteraction000518252
      WBInteraction000518286
      WBInteraction000522723
      WBInteraction000522724
      WBInteraction000522725
      WBInteraction000522726
      WBInteraction000522727
      WBInteraction000522728
      WBInteraction000522729
      WBInteraction000522730
      WBInteraction000522736
      WBInteraction000522737
      WBInteraction000522738
      WBInteraction000522746
      WBInteraction000523006
      WBInteraction000523047
      WBInteraction000523111
      WBInteraction000523209
      WBInteraction000523236
      WBInteraction000523349
      WBInteraction000523373
      WBInteraction000523422
      WBInteraction000523457
      WBInteraction000523469
      WBInteraction000523537
      WBInteraction000523577
      WBInteraction000523589
      WBInteraction000539898
      WBInteraction000541032
      WBInteraction000541830
      WBInteraction000542725
      WBInteraction000542749
      WBInteraction000542810
      WBInteraction000543620
      WBInteraction000543760
      WBInteraction000544259
      WBInteraction000544626
      WBInteraction000544627
      WBInteraction000544653
      WBInteraction000544656
      WBInteraction000544662
      WBInteraction000546091
      WBInteraction000546121
      WBInteraction000546188
      WBInteraction000546214
      WBInteraction000546516
      WBInteraction000546761
      WBInteraction000546831
      WBInteraction000550680
      WBInteraction000550765
      WBInteraction000550873
      WBInteraction000551149
      WBInteraction000551150
      WBInteraction000551326
      WBInteraction000556526
      WBInteraction000556527
      WBInteraction000556748
      WBInteraction000556749
      WBInteraction000563446
      WBInteraction000564986
      WBInteraction000565066
      WBInteraction000565976
      WBInteraction000568781
      WBInteraction000568926
      WBInteraction000573382
      WBInteraction000575168
      WBInteraction000576069
      WBInteraction000579593
      WBInteraction000579924
      WBInteraction000585088
      WBInteraction000586394
  Map_info: Map: IV Position: 2.0216 Error: 0.006342
    Positive: Positive_clone: B0547 Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference (20)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene