WormBase Tree Display for Gene: WBGene00000817

WBGene00000817 SMap: S_parent: Sequence: B0547
  Identity: Version: 1
    Name: CGC_name: csn-5 Person_evidence: WBPerson57
      Sequence_name: B0547.1
      Molecular_name: B0547.1
        B0547.1.1
        CE06722
      Other_name: CELE_B0547.1 Accession_evidence: NDB BX284604
      Public_name: csn-5
    DB_info: Database (12)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:21 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: csn
    Allele (25)
    Strain: WBStrain00001355
      WBStrain00036128
    RNASeq_FPKM (74)
    GO_annotation (33)
    Ortholog: WBGene00063974 Caenorhabditis remanei From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00039027 Caenorhabditis briggsae From_analysis: Hillier-set
            OrthoMCL
            OMA
            Inparanoid_8
            WormBase-Compara
      WBGene00161648 Caenorhabditis brenneri From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00154339 Caenorhabditis brenneri From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00134417 Caenorhabditis japonica From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00074259 Caenorhabditis remanei From_analysis: TreeFam
            WormBase-Compara
      WBGene00222111 Brugia malayi From_analysis: WormBase-Compara
      CBOVI.g8767 Caenorhabditis bovis From_analysis: WormBase-Compara
      CSP21.g13588 Caenorhabditis parvicauda From_analysis: WormBase-Compara
      CSP26.g20878 Caenorhabditis zanzibari From_analysis: WormBase-Compara
      CSP28.g6384 Caenorhabditis panamensis From_analysis: WormBase-Compara
      CSP29.g16534 Caenorhabditis becei From_analysis: WormBase-Compara
      CSP31.g21545 Caenorhabditis uteleia From_analysis: WormBase-Compara
      CSP32.g7367 Caenorhabditis sulstoni From_analysis: WormBase-Compara
      CSP38.g860 Caenorhabditis quiockensis From_analysis: WormBase-Compara
      CSP39.g16974 Caenorhabditis waitukubuli From_analysis: WormBase-Compara
      CSP39.g24156 Caenorhabditis waitukubuli From_analysis: WormBase-Compara
      CSP40.g20335 Caenorhabditis tribulationis From_analysis: WormBase-Compara
      Cang_2012_03_13_03457.g18100 Caenorhabditis angaria From_analysis: WormBase-Compara
      Cni-csn-5 Caenorhabditis nigoni From_analysis: WormBase-Compara
      Csp11.Scaffold630.g18583 Caenorhabditis tropicalis From_analysis: WormBase-Compara
      Csp5_scaffold_01100.g18389 Caenorhabditis sinica From_analysis: WormBase-Compara
      FL83_24011 Caenorhabditis latens From_analysis: WormBase-Compara
      GCK72_013577 Caenorhabditis remanei From_analysis: WormBase-Compara
      OTIPU.nOt.2.0.1.g03366 Oscheius tipulae From_analysis: WormBase-Compara
      Pan_g14818 Panagrellus redivivus From_analysis: WormBase-Compara
      Sp34_40226600 Caenorhabditis inopinata From_analysis: WormBase-Compara
      chrIV_pilon.g10481 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00245924 Onchocerca volvulus From_analysis: WormBase-Compara
      WBGene00281192 Pristionchus pacificus From_analysis: WormBase-Compara
      WBGene00262688 Strongyloides ratti From_analysis: WormBase-Compara
      WBGene00293194 Trichuris muris From_analysis: WormBase-Compara
      SGD:S000002375 Saccharomyces cerevisiae From_analysis: EnsEMBL-Compara
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      FB:FBgn0027053 Drosophila melanogaster From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      ZFIN:ZDB-GENE-040426-1686 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      HGNC:2240 Homo sapiens From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      MGI:1349415 Mus musculus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      RGD:1310301 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
    Paralog: WBGene00001231 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00018135 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00004467 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
    Structured_description: Concise_description: csn-5 encodes an ortholog of subunit 5 of the COP9 signalosome complex (CSN5), which in turn is a pan-eukaryotic multiprotein complex that positively regulates E3 ubiquitin ligases, physically interacts with SCF-type E3 ubiquitin ligases, and probably regulates protein degradation; CSN-5 (along with KGB-1 and ZYX-1) physically binds germline RNA helicases (GLH proteins), and csn-5(RNAi) results in sterile worms with small gonads and no oocytes, causing oogenesis to cease, but not affecting the initial assembly of P granules -- a defect essentially identical to that produced by RNAi with a combination of glh-1 and glh-4. Paper_evidence: WBPaper00004651
            WBPaper00005583
            WBPaper00012892
            WBPaper00013120
          Curator_confirmed: WBPerson567
          Date_last_updated: 17 Jun 2004 00:00:00
      Automated_description: Enables DEAD/H-box RNA helicase binding activity. Involved in gonad development; oogenesis; and protein deneddylation. Located in A band and nucleus. Expressed in tail. Human ortholog(s) of this gene implicated in hepatocellular carcinoma. Is an ortholog of human COPS5 (COP9 signalosome subunit 5). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:684 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:2240)
  Molecular_info: Corresponding_CDS: B0547.1
    Corresponding_transcript: B0547.1.1
    Other_sequence (62)
    Associated_feature: WBsf645978
      WBsf228325
  Experimental_info: RNAi_result (34)
    Expr_pattern: Chronogram16
      Expr2600
      Expr5086
      Expr8994
      Expr11941
      Expr1029217
      Expr1030508
      Expr1143331
      Expr2010554
      Expr2028794
    Drives_construct: WBCnstr00002247
      WBCnstr00002248
      WBCnstr00037262
    Construct_product: WBCnstr00037262
    Regulate_expr_cluster: WBPaper00029237:CSN-5_interacting
    Antibody: WBAntibody00000577
      WBAntibody00000628
      WBAntibody00001976
    Microarray_results (23)
    Expression_cluster (115)
    Interaction (186)
  Map_info: Map: IV Position: 2.0216 Error: 0.006342
    Positive: Positive_clone: B0547 Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference (20)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene