WormBase Tree Display for Gene: WBGene00000601

WBGene00000601 SMap: S_parent: Sequence: F15H10
  Identity: Version: 1
    Name: CGC_name: col-12 Person_evidence: WBPerson345
      Sequence_name: F15H10.1
      Molecular_name: F15H10.1
        F15H10.1.1
        CE05638
        F15H10.1.2
        F15H10.1.3
      Other_name: CELE_F15H10.1 Accession_evidence: NDB BX284605
      Public_name: col-12
    DB_info: Database: AceView gene 5K904
        WormQTL gene WBGene00000601
        WormFlux gene WBGene00000601
        NDB locus_tag CELE_F15H10.1
        Panther gene CAEEL|WormBase=WBGene00000601|UniProtKB=P20630
          family PTHR24637
        NCBI gene 179453
        RefSeq protein NM_073277.6
        SwissProt UniProtAcc P20630
        UniProt_GCRP UniProtAcc P20630
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:21 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: col
    Allele (19)
    Legacy_information: [C.elegansII] NMK. Transcripts detected late in each larval stage, at lethargus. Encodes collagen, col-6 family. Linked to col-13. [Cox and Hirsh 1985; IA]
    Strain: WBStrain00008605
    RNASeq_FPKM (74)
    GO_annotation: 00039844
      00039845
      00039846
      00107614
    Ortholog (44)
    Paralog (161)
    Structured_description: Concise_description: col-12 encodes a member of the collagen superfamily containing collagen triple helix repeats (20 copies); expressed throughout development but expression peaks after each larval molt when new cuticle is being secreted and deposited, and after the L4 to adult larval molt. Paper_evidence: WBPaper00000748
            WBPaper00001247
            WBPaper00002512
          Curator_confirmed: WBPerson48
          Date_last_updated: 17 Jun 2004 00:00:00
      Automated_description: Predicted to be a structural constituent of cuticle. Predicted to be part of collagen trimer. Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: F15H10.1
    Corresponding_transcript: F15H10.1.1
      F15H10.1.2
      F15H10.1.3
    Other_sequence (77)
    Associated_feature: WBsf652990
      WBsf1001109
      WBsf1001110
      WBsf234391
  Experimental_info: RNAi_result: WBRNAi00030236 Inferred_automatically: RNAi_primary
      WBRNAi00044760 Inferred_automatically: RNAi_primary
      WBRNAi00091328 Inferred_automatically: RNAi_primary
      WBRNAi00013393 Inferred_automatically: RNAi_primary
      WBRNAi00044759 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr611
      Expr612
      Expr756
      Expr767
      Expr2431
      Expr12253
      Expr1018167
      Expr1148722
      Expr2010325
      Expr2028569
    Drives_construct (41)
    Construct_product: WBCnstr00012448
      WBCnstr00037435
    Microarray_results: SMD_F15H10.1
      172878_x_at
      172879_x_at
      194205_x_at
      A_12_P149985
      Aff_F15H10.1
      GPL3518_CE05638
      GPL9450_F15H10.1
      cea2.p.158073
    Expression_cluster: WBPaper00032528:L3_enriched
      WBPaper00033065:cyc-1(RNAi)_upregulated
      WBPaper00037950:A-class-motor-neurons_L1-larva_expressed
      WBPaper00037950:A-class-motor-neurons_L2-larva_expressed
      WBPaper00037950:all-neurons_L1-larva_expressed
      WBPaper00037950:all-neurons_L2-larva_expressed
      WBPaper00037950:BAG-neuron_blastula-embryo_expressed
      WBPaper00037950:bodywall-muscle_L1-larva_expressed
      WBPaper00037950:bodywall-muscle_L2-larva_expressed
      WBPaper00037950:bodywall-muscle_larva_enriched
      WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed
      WBPaper00037950:coelomocytes_L2-larva_expressed
      WBPaper00037950:dopaminergic-neurons_L1-larva_expressed
      WBPaper00037950:excretory-cell_L2-larva_expressed
      WBPaper00037950:GABAergic-motor-neurons_L1-larva_expressed
      WBPaper00037950:germline-precursors_blastula-embryo_expressed
      WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed
      WBPaper00037950:glr-1(+)-neurons_larva_enriched
      WBPaper00037950:hypodermis_L1-larva_expressed
      WBPaper00037950:hypodermis_L3-L4-larva_expressed
      WBPaper00037950:intestine_L1-larva_expressed
      WBPaper00037950:intestine_L2-larva_expressed
      WBPaper00037950:pharyngeal-muscle_L1-larva_expressed
      WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
      WBPaper00038118:stress_upregulated_N2
      WBPaper00038438:P.lumniescens_24hr_upregulated_RNAseq
      WBPaper00038438:P.lumniescens_24hr_upregulated_TilingArray
      WBPaper00040134:nhr-49(RNAi)_regulated_protein
      WBPaper00040209:B.thuringiensis_downregulated_MY18
      WBPaper00040285:H2S_24hr_downregulated
      WBPaper00042477:prp-8(RNAi)_downregulated_RNAseq
      WBPaper00042477:rsr-2(RNAi)_upregulated_RNAseq
      WBPaper00042561:smgl-1(RNAi)_upregulated
      WBPaper00043945:MeHg_downregulated
      WBPaper00044037:eat-2_upregulated
      WBPaper00044260:1-methylnicotinamide_upregulated
      WBPaper00044260:nicotinc-acid_upregulated
      WBPaper00044578:reduced-humidity_downregulated_microarray
      WBPaper00044736:oscillating_dev_expression
      WBPaper00044786:emr-1(gk119)_upregulated
      WBPaper00044786:emr-1(RNAi);lem-2(tm1582)_upregulated
      WBPaper00045314:S.aureus-induced_hlh-30(tm1978)
      WBPaper00045314:S.aureus-induced_N2
      WBPaper00045521:Gender_Neutral
      WBPaper00045774:clk-1_upregulated
      WBPaper00045934:wrn-1(gk99)_upregulated
      WBPaper00046497:B.thuringiensis_0.1mix_downregulated_12h
      WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h
      WBPaper00046497:B.thuringiensis_downregulated_protein
      WBPaper00046527:glucose_upregulated
      WBPaper00046887:WNT-target
      WBPaper00047131:daf-2(e1370)_upregulated_hel-1(gk148684)-background
      WBPaper00047131:daf-2(e1370)_upregulated_N2-background
      WBPaper00047132:glp-1(ts)-25C_upregulated
      WBPaper00048611:MnCl2_downregulated
      WBPaper00048971:daf-16(mgDf50)_downregulated_L1
      WBPaper00048988:daf-2(e1370)_upregulated_neuron
      WBPaper00048988:neuron_expressed
      WBPaper00049266:trx-1(ok1449)_regulated_unstressed
      WBPaper00049495:starvation-refeeding_regulated
      WBPaper00049498:npr-1(ur89)_regulated_3
      WBPaper00049635:dop-1(vs100)_downregulated
      WBPaper00049905:Age_variant_expression
      WBPaper00049920:Glucose-Diet_upregulated_hyl-2(tm2031)
      WBPaper00049920:Glucose-Diet_upregulated_N2
      WBPaper00049920:hyl-2(tm2031)_upregulated
      WBPaper00049942:HeatShock_upregulated_hsf-1(+)
      WBPaper00049954:BPS_downregulated
      WBPaper00050193:cec-4(ok3124)_upregulated_L1
      WBPaper00050332:daf-16(RNAi)_downregulated
      WBPaper00050332:skn-1(RNAi)_downregulated
      WBPaper00050344:AFD-neuron_enriched
      WBPaper00050370:dpy-21(e428)_L3_downregulated
      WBPaper00050488:20C_vs_25C_regulated_N2_adult
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050726:OsmoticStress_regulated_Food
      WBPaper00050726:OsmoticStress_regulated_NoFood
      WBPaper00050801:DAF-12_dauer_regulome
      WBPaper00050801:DAF-16_dauer_regulome
      WBPaper00050801:DPY-21_dauer_regulome
      WBPaper00050859:upregulated_glh-1(gk100)_vs_control_day1-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult
      WBPaper00050903:mir-35-41(nDf50)_25C_upregulated
      WBPaper00050990:arcade_intestinal-valve_expressed
      WBPaper00050990:GABAergic-neuron_expressed
      WBPaper00050990:hypodermis_expressed
      WBPaper00050990:NMDA-neuron_expressed
      WBPaper00051265:F1_morc-1(tm6048)_upregulated
      WBPaper00051265:F4_hrde-1(tm1200)_downregulated
      WBPaper00051265:F4_morc-1(tm6048)_downregulated
      WBPaper00051352:Long-Term-Association-Memory_downregulated
      WBPaper00051371:Orsay-virus-infection_upregulated_rde-1(ne219)
      WBPaper00051404:alg-1(gk214)_upregulated
      WBPaper00051404:alg-2(ok304)_upregulated
      WBPaper00052884:emb-4(hc60)_upregulated
      WBPaper00053023:nrx-1(tm1961)_downregulated
      WBPaper00053184:sma-2(rax5)_upregulated
      WBPaper00053184:sma-4(rax3)_upregulated
      WBPaper00053295:lin-22(icb38)_downregulated
      WBPaper00053295:lin-22(ot269)_downregulated
      WBPaper00053302:stavudine_24h_regulated
      WBPaper00053302:zidovudine_72h_regulated
      WBPaper00053318:Aging_downregulated_mRNA_N2
      WBPaper00053318:mir-71(n4115)_downregulated_mRNA
      WBPaper00053402:cco-1(RNAi)_downregulated
      WBPaper00053713:Pheromone-induced_postdauer_vs_control_downregulated
      WBPaper00053713:Starvation-induced_postdauer_vs_control_upregulated
      WBPaper00053771:up_at_dpy-7(e88)
      WBPaper00054191:H3.3(null)_L1_downregulated
      WBPaper00054872:egl-9(sa307)_upregulated
      WBPaper00055013:hmg-3(bar24)_downregulated
      WBPaper00055013:hmg-4(RNAi)_downregulated
      WBPaper00055049:S.gordonii_downregulated
      WBPaper00055354:eat-2(ad1116)_upregulated
      WBPaper00055354:Psora-Allantoin_downregulated
      WBPaper00055354:Rapamycin-Rifampicin-Psora_upregulated
      WBPaper00055354:Rifampicin-Allantoin_downregulated
      WBPaper00055626:pry-1(mu38)_downregulated
      WBPaper00055827:pfd-6(gk493446)_downregulated
      WBPaper00055897:heat-shock_upregulated
      WBPaper00055944:C.butyricum_vs_OP50_downregulated
      WBPaper00055969:electromagnetic-field_upregulated
      WBPaper00055971:nhl-2(ok818)_20C_downregulated
      WBPaper00055971:nhl-2(ok818)_25C_downregulated
      WBPaper00056034:pals-22(jy3)_upregulated
      WBPaper00056034:pals-25(jy9)_downregulated
      WBPaper00056039:ptl-1(ok621)_downregulated
      WBPaper00056039:ptrn-1(tm5597)_downregulated
      WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047)
      WBPaper00056139:soil-microbiota_upregulated
      WBPaper00056167:Cry5B_downregulated
      WBPaper00056284:ints-11(RNAi)_downregulated
      WBPaper00056443:DietaryRestriction_downregulated
      WBPaper00056443:sek-1(km4)_upregulated
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_downregulated
      WBPaper00056586:kri-1(ok1251)_upregulated
      WBPaper00056586:mpk-2(ok219)_upregulated
      WBPaper00056617:adr-1_upregulated_embryo_transcript
      WBPaper00057041:spc-1(cas971)_upregulated
      WBPaper00057041:unc-70(cas983)_upregulated
      WBPaper00058725:sftb-1(cer6)_downregulated
      WBPaper00058948:npr-8(ok1439)_downregulated_OP50
      WBPaper00058955:heatshock_upregulated_CE
      WBPaper00058969:RIS_depleted
      WBPaper00059117:B.subtilis_upregulated
      WBPaper00059334:sacy-1(depletion)_regulated
      WBPaper00059421:daf-1(m40);daf-3(mgDf90)_upregulated
      WBPaper00059421:daf-1(m40)_upregulated
      WBPaper00059566:wdr-23(mac32)_upregulated
      WBPaper00059605:mut-16(pk710)_upregulated
      WBPaper00059728:5ug_cholesterol_upregulated
      WBPaper00059728:20ug_cholesterol_upregulated
      WBPaper00059739:hira-1(gk835598)_downregulated_L1
      WBPaper00059739:hira-1(gk835598)_downregulated_L4
      WBPaper00059739:hira-1(gk835598)_upregulated_adult
      WBPaper00059754:C.neoformans_H99_upregulated
      WBPaper00059816:crh-1(n3315)_uprgulated
      WBPaper00059824:rnp-6(dh1127)_regulated_OP50
      WBPaper00059824:rnp-6(dh1127)_regulated_S.aureus
      WBPaper00060014:set-2(tm1630)_downregulated
      WBPaper00060273:isp-1(qm150)_upregulated
      WBPaper00060273:vrk-1(RNAi)_downregulated
      WBPaper00060358:B.thuringiensis_non-pathogen_regulated_elt-2(RNAi)
      WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi)
      WBPaper00060358:B.thuringiensis_pathogen_regulated_N2
      WBPaper00060399:pqm-1(ok485)_upregulated_CoCl2_6hr
      WBPaper00060434:pH4.33_vs_pH6.33_uprgulated
      WBPaper00060445:nfki-1(cer1)_downregulated_L1
      WBPaper00060459:bcat-1(RNAi)_upregulated
      WBPaper00060661:sensory-neuron_depleted
      WBPaper00060683:hlh-11(ko1)_upregulated
      WBPaper00060764:swsn-1(os22ts)_upregulated
      WBPaper00060811:L1_vs_adult_downregulated_neural
      WBPaper00060871:M.humicola-extract_1h_regulated
      WBPaper00060909:atfs-1(cmh15)_upregulated
      WBPaper00060951:mrpl-2(osa3)_downregulated
      WBPaper00061007:HB101_upregulated
      WBPaper00061040:eat-2(ad1116)_downregulated
      WBPaper00061081:skpo-1(ok1640)_upregulated_OP50
      WBPaper00061274:hypergravity_15xg_upregulated
      WBPaper00061340:B_F_K_Kp_U_Y
      WBPaper00061340:PVR
      WBPaper00061390:daf-22(ok693)_ascarosides_downregulated
      WBPaper00061424:Diet_MYb120_upregulated
      WBPaper00061479:hda-1(ne4752)_upregulated
      WBPaper00061479:mep-1(ne4629)_upregulated
      WBPaper00061479:prg-1(tm872)_upregulated
      WBPaper00061527:col-146-col-133
      WBPaper00061699:daf-18(ok480)_downregulated
      WBPaper00061919:oef-1(vr25)_regulated
      WBPaper00061952:daf-18(nr2037)_downregulated
      WBPaper00061952:daf-18(yh1)_downregulated
      WBPaper00061995:mter-4(syb3662syb3403)_downregulated
      WBPaper00062159:hda-2(ok1479)_upregulated
      WBPaper00062193:daf-16(RNAi)_upregulated
      WBPaper00062193:skn-1(RNAi)_upregulated
      WBPaper00062325:muscle_depleted_coding-RNA
      WBPaper00062456:doxycycline_upregulated_CB4856_protein
      WBPaper00062456:doxycycline_upregulated_CB4856_transcript
      WBPaper00062456:doxycycline_upregulated_N2_transcript
      WBPaper00062520:qui-1(db104)_downregulated
      WBPaper00062585:hlh-26(ok1453)_upregulated_E.faecium
      WBPaper00064005:starvation_downregulated_N2_mRNA
      WBPaper00064088:Day-1-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-1-adult_vs_L4_downregulated_fem-3(q20)
      WBPaper00064088:Day-1-adult_vs_L4_downregulated_glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20)
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_glp-1(e2141)
      WBPaper00064107:lin-35(n745)_downregulated
      WBPaper00064122:vulva_transcriptome
      WBPaper00064229:B.thuringiensis-Cry5Ba_upregulated
      WBPaper00064291:antimycin_upregulated
      WBPaper00064306:Agaro-oligosaccharides_upregulated
      WBPaper00064494:postdauer_downregulated_WholeAnimal
      WBPaper00064505:tamoxifen_downregulated
      WBPaper00064509:static-magnetic-field_upregulated
      WBPaper00064532:pals-25(icb98)_upregulated
      WBPaper00064716:paraquat_upregulated
      WBPaper00064727:daf-2(e1370)_upregulated
      WBPaper00064728:cpl-1(W32AY35A)_upregulated
      WBPaper00064933:bcf-1(ylf1)_downregulated_transcript
      WBPaper00065029:cadmium_downregulated
      WBPaper00065096:25C_vs_20C_downregulated
      WBPaper00065096:Day10_vs_Day1_downregulated
      WBPaper00065096:npr-8(ok1439)_downregulated_Day10_20C
      WBPaper00065096:npr-8(ok1439)_upregulated_Day1_25C
      WBPaper00065120:body-muscle-transcriptome
      WBPaper00065158:25C_vs_15C_downregulated_WholeAnimal
      WBPaper00065315:mating_upregulated_Day2-7
      WBPaper00065373:Cisplatin_downregulated_WT
      WBPaper00065560:E.coli-HB101_downregulated_F3
      WBPaper00065578:gcn-1(nc40)_upregulated
      WBPaper00065581:hpk-1(pk1393)_upregulated
      WBPaper00065746:eat-2(ad1113)_downregulated
      WBPaper00065841:82_0
      WBPaper00065849:ursolic-acid_regulated
      WBPaper00066038:mip-1(how5)_upregulated
      WBPaper00066093:E.coli-purE_upregulated
      WBPaper00066110:Cisplatin_upregulated_diploid
      WBPaper00066110:Doxorubicin_upregulated_diploid
      WBPaper00066110:tetraploid_vs_diploid_upregulated
      WBPaper00066146:germline-inx-14(RNAi)_upregulated_PA14
      WBPaper00066232:ash-2(RNAi)_downregulated_WT
      WBPaper00066232:hsf-1(RNAi)_upregulated_ash-2
      WBPaper00066232:hsf-1(RNAi)_upregulated_WT
      cgc4386_cluster_1_3
      cgc4489_group_1
      WBPaper00005124:cholesterol_10-9M_regulated
      WBPaper00005124:estrogen_10-5M_regulated
      WBPaper00005124:progesterone_10-7M_regulated
      WBPaper00024393:strongly_regulated_dauer_genes
      WBPaper00025032:cluster_164
      WBPaper00025099:MA_specific
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00025141:unc-4::GFP_Expressed_Genes
      WBPaper00026929:Resveratrol_regulated_daf-16
      WBPaper00026929:sir-2.1_overexpression_regulated
      WBPaper00028789:PA14_vs_gacA_downregulated_8hr
      WBPaper00028789:PA14_vs_OP50_downregulated_8hr
      WBPaper00031060:2-deoxy-D-glucose_upregulated
      WBPaper00031532:Larva_Pan_Neuronal_Depleted
      WBPaper00032062:age_regulated_genes
      WBPaper00032948:FedUp
      WBPaper00033101:spr-5_regulated
      WBPaper00034757:down_by_oxidative_stress
      WBPaper00035479:glucose_upregulated
      WBPaper00035873:dpy-9_regulated
      WBPaper00035873:dpy-10_regulated
      WBPaper00035892:Y.pestis_regulated
      WBPaper00036286:Pattern_G
      WBPaper00036375:depleted_in_PVD_OLL
      WBPaper00036383:ash-2_Day8_regulated
      WBPaper00037113:CPF_16C_down-regulated
      WBPaper00038172:aak-2overexpression_up_regulated
      WBPaper00038172:crh-1null_up_regulated
      WBPaper00038172:tax-6null_up_regulated
      WBPaper00038427:lin-54_embryo_changed
      WBPaper00040858:eQTL_age_regulated_aging
      WBPaper00040858:eQTL_regulated_old
      WBPaper00040876:mir-35_downregulated
      WBPaper00040963:Q50_up
      WBPaper00040963:Q200_up
      WBPaper00040963:TA100_up
      WBPaper00040963:TA200_up
      WBPaper00040963:TA300_up
      WBPaper00041002:HF_11d_2.0mM_Up
      WBPaper00041002:HQ_3d_2.0mM_Down
      WBPaper00041939:control_vs_EtBr-exposed_48h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_51h
      WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_51h
      WBPaper00042258:DA1877_upregulated_GravidAdult
      WBPaper00042274:tbx-2(bx59)_upregulated
      WBPaper00045374:Benzene_upregulated
      WBPaper00045960:L1-L4-lethargus_upregulated
      WBPaper00045960:L4-lethargus_upregulated
      WBPaper00046548:dafachronic-acid_downregulated
      WBPaper00047070:DAF-16-dependent_UV_response
      WBPaper00048624:hlh-25(ok1710)_upregulated
      WBPaper00048637:lin-35(n745)_starvation_downregulated
      WBPaper00048989:eat-2(ad465)_downregulated_in-DMSO
      WBPaper00048989:eat-2(ad465)_rapamycin_upregulated
      WBPaper00053550:daf-19(m86)_downregulated_L1
      WBPaper00057098:SiO2-nanoparticles_downregulated
      [cgc6390]:Cluster_C
    Interaction (105)
  Map_info: Map: V Position: 2.54658 Error: 0.000295
    Positive: Positive_clone: CH#COL12
        F15H10 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference (37)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene