WormBase Tree Display for Gene: WBGene00000554
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| WBGene00000554 | Evidence | Paper_evidence | WBPaper00005483 | ||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | F55C10 | ||||||
| Identity | Version | 1 | |||||||
| Name | CGC_name | cnb-1 | Person_evidence | WBPerson746 | |||||
| Sequence_name | F55C10.1 | ||||||||
| Molecular_name | F55C10.1a | ||||||||
| F55C10.1a.1 | |||||||||
| CE32679 | |||||||||
| F55C10.1b | |||||||||
| CE47380 | |||||||||
| F55C10.1b.1 | |||||||||
| Other_name | CELE_F55C10.1 | Accession_evidence | NDB | BX284605 | |||||
| Public_name | cnb-1 | ||||||||
| DB_info | Database | AceView | gene | 5L857 | |||||
| WormQTL | gene | WBGene00000554 | |||||||
| WormFlux | gene | WBGene00000554 | |||||||
| NDB | locus_tag | CELE_F55C10.1 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00000554|UniProtKB=G5EDN6 | |||||||
| family | PTHR45942 | ||||||||
| NCBI | gene | 179572 | |||||||
| RefSeq | protein | NM_001269389.2 | |||||||
| NM_001269388.2 | |||||||||
| SwissProt | UniProtAcc | G5EDN6 | |||||||
| TrEMBL | UniProtAcc | H9G2Y1 | |||||||
| UniProt_GCRP | UniProtAcc | G5EDN6 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:21 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | cnb | ||||||||
| Allele (25) | |||||||||
| Strain | WBStrain00023526 | ||||||||
| WBStrain00036229 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (14) | |||||||||
| Ortholog (40) | |||||||||
| Paralog | WBGene00003941 | Caenorhabditis elegans | From_analysis | WormBase-Compara | |||||
| WBGene00009260 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00014109 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00019108 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00020192 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| Structured_description | Concise_description | cnb-1 encodes an ortholog of calcineurin B, the regulatory subunit of the protein phosphatase 2B with four EF-hand motifs for calcium binding, that binds TAX-6 (a calcineurin A ortholog) in a calcium-dependent manner; CNB-1 binds calcium, enhances the phosphatase activity of TAX-6 in vitro, promotes transcription of rcn-1, and is required for normal cuticle formation, sperm morphology, and brood size; cnb-1 null mutants exhibit an extended lifespan which is characterized by enhanced autophagy and dependent upon the presence of functional bec-1 and atg-7. | Paper_evidence | WBPaper00005483 | |||||
| WBPaper00005829 | |||||||||
| WBPaper00032986 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 29 Apr 2009 00:00:00 | ||||||||
| Automated_description | Enables calcium ion binding activity. Predicted to be involved in calcineurin-mediated signaling. Located in endoplasmic reticulum; sarcomere; and striated muscle dense body. Expressed in several structures, including germ line; gonad; muscle cell; neurons; and somatic nervous system. Human ortholog(s) of this gene implicated in Alzheimer's disease and dilated cardiomyopathy. Is an ortholog of human PPP3R1 (protein phosphatase 3 regulatory subunit B, alpha). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:10652 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9317) | ||||
| DOID:12930 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9317) | ||||||
| Molecular_info | Corresponding_CDS | F55C10.1a | |||||||
| F55C10.1b | |||||||||
| Corresponding_CDS_history | F55C10.1:wp91 | ||||||||
| Corresponding_transcript | F55C10.1a.1 | ||||||||
| F55C10.1b.1 | |||||||||
| Other_sequence (57) | |||||||||
| Associated_feature | WBsf647255 | ||||||||
| WBsf661720 | |||||||||
| WBsf1001332 | |||||||||
| WBsf1001333 | |||||||||
| WBsf1001334 | |||||||||
| WBsf1020439 | |||||||||
| WBsf1020440 | |||||||||
| WBsf232496 | |||||||||
| WBsf232497 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00048457 | Inferred_automatically | RNAi_primary | |||||
| Expr_pattern (12) | |||||||||
| Drives_construct | WBCnstr00003250 | ||||||||
| WBCnstr00010474 | |||||||||
| WBCnstr00010565 | |||||||||
| WBCnstr00037457 | |||||||||
| Construct_product | WBCnstr00010565 | ||||||||
| WBCnstr00013993 | |||||||||
| WBCnstr00037457 | |||||||||
| Regulate_expr_cluster | WBPaper00027022:cnb-1(jh103)_downregulated | ||||||||
| WBPaper00027022:cnb-1(jh103)_upregulated | |||||||||
| Antibody | WBAntibody00000561 | ||||||||
| Microarray_results (22) | |||||||||
| Expression_cluster (174) | |||||||||
| Interaction (71) | |||||||||
| Map_info | Map | V | Position | 3.07846 | Error | 0.000352 | |||
| Positive | Positive_clone | F55C10 | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Mapping_data | Multi_point | 4230 | |||||||
| Pseudo_map_position | |||||||||
| Reference (48) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
