WormBase Tree Display for Gene: WBGene00000537
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| WBGene00000537 | Evidence | CGC_data_submission | |||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | C07H6 | ||||||
| Identity | Version | 1 | |||||||
| Name | CGC_name | clk-2 | Person_evidence | WBPerson247 | |||||
| Sequence_name | C07H6.6 | ||||||||
| Molecular_name | C07H6.6 | ||||||||
| C07H6.6.1 | |||||||||
| CE30240 | |||||||||
| Other_name | rad-5 | ||||||||
| CELE_C07H6.6 | Accession_evidence | NDB | BX284603 | ||||||
| Public_name | clk-2 | ||||||||
| DB_info | Database | AceView | gene | 3I606 | |||||
| WormQTL | gene | WBGene00000537 | |||||||
| WormFlux | gene | WBGene00000537 | |||||||
| NDB | locus_tag | CELE_C07H6.6 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00000537|UniProtKB=Q95YE9 | |||||||
| family | PTHR15830 | ||||||||
| NCBI | gene | 176065 | |||||||
| RefSeq | protein | NM_001382917.2 | |||||||
| SwissProt | UniProtAcc | Q95YE9 | |||||||
| TREEFAM | TREEFAM_ID | TF313925 | |||||||
| UniProt_GCRP | UniProtAcc | Q95YE9 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:21 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | clk | ||||||||
| Reference_allele | WBVar00089075 | ||||||||
| Allele (44) | |||||||||
| Possibly_affected_by | WBVar02157226 | ||||||||
| Legacy_information | [Lakowski B] At 20C clk-2(qm37) worms take 3.5 to 4 days to develop from egg to egglaying adult and throw small broods. Worms arrest development soon after transfer to 25C. Adults transfered to 25C lay some dead eggs. | ||||||||
| [Hekimi S]qm37 slow growth and rhythms, phenotypes similar to Clk-1; profound maternal and zygotic rescue; embryonic lethal at 25C, some lethality at all temperatures. NA1. | |||||||||
| [C.elegansII] qm37 : slow growth and rhythms, phenotypes similar to Clk-1; profound maternal and zygotic rescue; embryonic lethal at 25C, some lethality at all temperatures. NA1. [MQ] | |||||||||
| mn159ts : hypersensitive to UV and X irradiation not to MMS; reduced brood size at 20x (7% of wildtype) sterile at 25x; increased spontaneous mutability. ES2 ME2. NA1. | |||||||||
| [C.elegansII] mn159ts : hypersensitive to UV and X irradiation, not to MMS; reduced brood size at 20C (7% of wildtype); sterile at 25C; increased spontaneous mutability. ES2 ME2. NA1. [Hartman and Herman 1982; PH] | |||||||||
| Strain | WBStrain00026638 | ||||||||
| WBStrain00026641 | |||||||||
| WBStrain00026648 | |||||||||
| WBStrain00026665 | |||||||||
| WBStrain00034250 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (18) | |||||||||
| Contained_in_operon | CEOP3444 | ||||||||
| Ortholog (25) | |||||||||
| Structured_description | Concise_description | The clk-2 gene encodes an ortholog of the S. cerevisiae telomere length-regulating protein Tel2p that has been shown to bind a number of DNA structures in vitro, including single-, double- and four-stranded DNA; in C. elegans, CLK-2 activity is required for the DNA damage and S phase replication checkpoints, for embryonic development, and for normal biological rhythms and life span; a functional CLK-2::GFP fusion protein is detected exclusively in the cytoplasm of somatic tissues. | Paper_evidence | WBPaper00003984 | |||||
| WBPaper00004941 | |||||||||
| WBPaper00004951 | |||||||||
| WBPaper00005024 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 07 Jul 2005 00:00:00 | ||||||||
| Automated_description | Predicted to enable Hsp90 protein binding activity and telomeric DNA binding activity. Involved in several processes, including DNA damage checkpoint signaling; determination of adult lifespan; and response to radiation. Located in cytoplasm. Expressed in several structures, including distal tip cell; gonad; head ganglion; and preanal ganglion neurons. Is an ortholog of human TELO2 (telomere maintenance 2). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | C07H6.6 | |||||||
| Corresponding_transcript | C07H6.6.1 | ||||||||
| Other_sequence | Acan_isotig06290 | ||||||||
| CR03700 | |||||||||
| EX542975.1 | |||||||||
| CR12607 | |||||||||
| ACC09926_1 | |||||||||
| CRC07742_1 | |||||||||
| Dviv_isotig34222 | |||||||||
| Associated_feature | WBsf226995 | ||||||||
| WBsf226996 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00064259 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00064258 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00005404 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00092480 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00040046 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00098005 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00076019 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00001762 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr1675 | ||||||||
| Expr1676 | |||||||||
| Expr1677 | |||||||||
| Expr15930 | |||||||||
| Expr1021547 | |||||||||
| Expr1030322 | |||||||||
| Expr1144113 | |||||||||
| Expr2010239 | |||||||||
| Expr2028481 | |||||||||
| Drives_construct | WBCnstr00010368 | ||||||||
| WBCnstr00019841 | |||||||||
| WBCnstr00037465 | |||||||||
| Construct_product | WBCnstr00019841 | ||||||||
| WBCnstr00037465 | |||||||||
| Antibody | WBAntibody00000420 | ||||||||
| WBAntibody00001904 | |||||||||
| Microarray_results (20) | |||||||||
| Expression_cluster (103) | |||||||||
| Interaction (167) | |||||||||
| WBProcess | WBbiopr:00000014 | ||||||||
| WBbiopr:00000066 | |||||||||
| WBbiopr:00000091 | |||||||||
| Map_info | Map | III | Position | -0.724525 | Error | 0.002766 | |||
| Well_ordered | |||||||||
| Positive | Positive_clone | C07H6 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| C07H8 | |||||||||
| Negative | Outside_rearr | nDf20 | |||||||
| Mapping_data | 2_point | 7068 | |||||||
| Multi_point | 2742 | ||||||||
| 2743 | |||||||||
| 3622 | |||||||||
| 3623 | |||||||||
| 368 | |||||||||
| 369 | |||||||||
| 4214 | |||||||||
| 4475 | |||||||||
| Pos_neg_data | 9314 | ||||||||
| Reference (128) | |||||||||
| Picture | WBPicture0000013091 | ||||||||
| Remark | Sequence connection from [Benard C, Hekimi S, Gartner A] | ||||||||
| old_name rad-5 becomes new_name clk-2 from [Gartner A]. | |||||||||
| Method | Gene |
