WormBase Tree Display for Gene: WBGene00000531

WBGene00000531 SMap: S_parent: Sequence: T06F4
  Identity: Version: 1
    Name: CGC_name: clh-4
      Sequence_name: T06F4.2
      Molecular_name: T06F4.2a
        T06F4.2a.1
        CE38544
        T06F4.2b
        CE28648
        T06F4.2b.1
      Other_name: T06F4.a Curator_confirmed: WBPerson1983
          Remark: Old cosmid naming mapped via unique overlapping PCR_product on CDSs
        T06F4.b Curator_confirmed: WBPerson1983
          Remark: Old cosmid naming mapped via unique overlapping PCR_product on CDSs
        CELE_T06F4.2 Accession_evidence: NDB BX284606
      Public_name: clh-4
    DB_info: Database (11)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:21 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: clh
    Allele (98)
    Strain: WBStrain00031843
      WBStrain00037721
    RNASeq_FPKM (74)
    GO_annotation (12)
    Ortholog (36)
    Paralog: WBGene00000528 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00000529 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00000530 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00000532 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00000533 Caenorhabditis elegans From_analysis: WormBase-Compara
    Structured_description: Automated_description: Predicted to enable voltage-gated chloride channel activity. Predicted to be involved in chloride transport. Predicted to be located in plasma membrane. Expressed in excretory cell. Human ortholog(s) of this gene implicated in Thomsen disease; idiopathic generalized epilepsy 11; and primary hyperaldosteronism. Is an ortholog of human CLCN1 (chloride voltage-gated channel 1) and CLCN2 (chloride voltage-gated channel 2). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:446 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:2020)
      DOID:0081336 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:2019)
      DOID:2106 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:2019)
      DOID:0111312 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:2020)
  Molecular_info: Corresponding_CDS: T06F4.2a
      T06F4.2b
    Corresponding_CDS_history: T06F4.2a:wp142
    Corresponding_transcript: T06F4.2a.1
      T06F4.2b.1
    Other_sequence: JI171877.1
      JI223678.1
      Dviv_isotig25055
      Tcol_isotig11995
      Tcol_isotig11996
      HG08696
      Acan_isotig12058
      Oden_isotig24653
      Tcol_isotig18311
      HGC03609_1
    Associated_feature (11)
  Experimental_info: RNAi_result: WBRNAi00035277 Inferred_automatically: RNAi_primary
      WBRNAi00018319 Inferred_automatically: RNAi_primary
      WBRNAi00052678 Inferred_automatically: RNAi_primary
      WBRNAi00077548 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr1125
      Expr1190
      Expr1010424
      Expr1156283
      Expr2010231
      Expr2028473
    Drives_construct: WBCnstr00005887
      WBCnstr00007706
      WBCnstr00010093
      WBCnstr00010142
      WBCnstr00037469
    Construct_product: WBCnstr00037469
    Microarray_results (25)
    Expression_cluster: WBPaper00031040:Cluster_3
      WBPaper00031040:TGF-beta_adult_upregulated
      WBPaper00037950:A-class-motor-neurons_L1-larva_expressed
      WBPaper00037950:all-neurons_L2-larva_expressed
      WBPaper00037950:AVE-neuron_L1-larva_expressed
      WBPaper00037950:bodywall-muscle_L1-larva_expressed
      WBPaper00037950:coelomocytes_L1-larva_expressed
      WBPaper00037950:excretory-cell_L2-larva_expressed
      WBPaper00037950:excretory-cell_larva_enriched
      WBPaper00037950:excretory-cell_larva_SelectivelyEnriched
      WBPaper00037950:GABAergic-motor-neurons_larva_SelectivelyEnriched
      WBPaper00037950:germline-precursors_blastula-embryo_expressed
      WBPaper00037950:hypodermis_L1-larva_expressed
      WBPaper00037950:intestine_L1-larva_expressed
      WBPaper00037950:intestine_L2-larva_expressed
      WBPaper00037950:pharyngeal-muscle_L1-larva_expressed
      WBPaper00042215:wdr-23(tm1817)_upregulated
      WBPaper00044736:flat_dev_expression
      WBPaper00044743:wdr-23_neuron_upregulated
      WBPaper00045420:fertilization_downregulated_transcript
      WBPaper00045774:clk-1_downregulated
      WBPaper00045774:clk-1_downregulated_CoQ10_independent
      WBPaper00047131:daf-2(e1370)_upregulated_hel-1(gk148684)-background
      WBPaper00048923:Aging_regulated
      WBPaper00049545:jmjd-3.1(+)_upregulated
      WBPaper00049942:HeatShock_upregulated_hsf-1(+)
      WBPaper00049942:HeatShock_upregulated_hsf-1(RNAi)
      WBPaper00050370:dpy-21(e428)_L3_upregulated
      WBPaper00050726:OsmoticStress_regulated_Food
      WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00052884:emb-4(hc60)_upregulated
      WBPaper00053184:sma-2(rax5)_upregulated
      WBPaper00053308:SMG-2_associated_NMD(-)_unaltered_ClassII
      WBPaper00053388:dauer_regulated_Cluster1
      WBPaper00053810:isp-1(qm150)_downregulated
      WBPaper00054493:hpl-2(tm1489)_upregulated
      WBPaper00055354:eat-2(ad1116)_downregulated
      WBPaper00055354:Psora-Allantoin_downregulated
      WBPaper00055354:Psora_downregulated
      WBPaper00055354:Rapamycin-Allantoin_downregulated
      WBPaper00055354:Rapamycin-Metformin_downregulated
      WBPaper00055354:Rapamycin-Rifampicin-Allantoin_downregulated
      WBPaper00055354:Rapamycin-Rifampicin_downregulated
      WBPaper00055354:Rapamycin_downregulated
      WBPaper00055354:Rifampicin-Allantoin_downregulated
      WBPaper00055354:Rifampicin-Psora_downregulated
      WBPaper00055354:Rifampicin_downregulated
      WBPaper00055897:heat-shock_upregulated
      WBPaper00055971:nhl-2(ok818)_25C_downregulated
      WBPaper00056617:adr-1_upregulated_embryo_transcript
      WBPaper00058948:PA14_downregulated
      WBPaper00058969:RIS_depleted
      WBPaper00059421:daf-1(m40)_upregulated
      WBPaper00059605:mut-16(pk710)_upregulated
      WBPaper00059664:srbc-48(ac23)_upregulated
      WBPaper00060100:SiNP_upregulated_mRNA
      WBPaper00060661:sensory-neuron_depleted
      WBPaper00061007:S.aquatilis_upregulated
      WBPaper00061340:Excretory_cell
      WBPaper00061341:28C_24h_upregulated
      WBPaper00061341:28C_48h_upregulated
      WBPaper00061479:hda-1(ne4752)_upregulated
      WBPaper00061527:ckr-1-T09B9.3
      WBPaper00061902:camt-1(ok515)_regulated_RMG
      WBPaper00061995:mter-4(syb3662syb3403)_downregulated
      WBPaper00062159:hda-2(ok1479)_upregulated
      WBPaper00062325:etr-1(lq61)_upregulated
      WBPaper00062325:muscle_depleted_coding-RNA
      WBPaper00062585:hlh-26(ok1453)_upregulated_E.faecium
      WBPaper00064005:starvation_upregulated_N2_mRNA
      WBPaper00064071:NHR-49_interacting
      WBPaper00064088:Day-1-adult_vs_L4_downregulated_fem-3(q20)
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20)
      WBPaper00064637:cox-5B(RNAi)_upregulated
      WBPaper00064939:vit-5(RNAi)_upregulated
      WBPaper00065096:25C_vs_20C_downregulated
      WBPaper00065096:Day10_vs_Day1_downregulated
      WBPaper00065581:hpk-1(pk1393)_upregulated
      WBPaper00065841:79_1
      WBPaper00065975:P-body_vs_WholeAnimal_depleted
      WBPaper00065993:glp-1(e2141)_upregulated
      WBPaper00066146:germline-inx-14(RNAi)_upregulated_PA14
      WBPaper00066232:ash-2(RNAi)_downregulated_WT
      cgc4489_group_5
      WBPaper00026929:sir-2.1_overexpression_regulated
      WBPaper00030985:Erwinia_carotovora_downregulated
      WBPaper00036123:Atrazine_regulated
      WBPaper00036123:Cadmium_regulated
      WBPaper00040184:hcf-1nc_sir-2.1nc_daf-2up
      WBPaper00040210:Chlorpyrifos_16C_regulated
      WBPaper00041939:control_vs_EtBr-exposed_48h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_51h
      WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00042236:flcn-1(ok975)_upregulated
    Interaction (42)
  Map_info: Map: X Position: -8.50461 Error: 0.115815
    Positive: Positive_clone: T06F4 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 5017
    Pseudo_map_position
  Reference (15)
  Remark: sequence connection from [George AL]
    Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene