WormBase Tree Display for Gene: WBGene00000421
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WBGene00000421 | SMap | S_parent | Sequence | C48B4 | |||||
---|---|---|---|---|---|---|---|---|---|
Identity | Version | 1 | |||||||
Name | CGC_name | ced-7 | Person_evidence | WBPerson261 | |||||
Sequence_name | C48B4.4 | ||||||||
Molecular_name (13) | |||||||||
Other_name | CELE_C48B4.4 | Accession_evidence | NDB | BX284603 | |||||
Public_name | ced-7 | ||||||||
DB_info | Database | AceView | gene | 3K660 | |||||
WormQTL | gene | WBGene00000421 | |||||||
WormFlux | gene | WBGene00000421 | |||||||
NDB | locus_tag | CELE_C48B4.4 | |||||||
Panther | gene | CAEEL|WormBase=WBGene00000421|UniProtKB=P34358 | |||||||
family | PTHR19229 | ||||||||
NCBI | gene | 176352 | |||||||
RefSeq | protein | NM_066714.5 | |||||||
NM_001026054.4 | |||||||||
NM_001268083.3 | |||||||||
NM_001379863.2 | |||||||||
SwissProt | UniProtAcc | P34358 | |||||||
TrEMBL | UniProtAcc | C0P274 | |||||||
UniProt_GCRP | UniProtAcc | P34358 | |||||||
Species | Caenorhabditis elegans | ||||||||
History | Version_change | 1 | 07 Apr 2004 11:29:20 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
Status | Live | ||||||||
Gene_info | Biotype | SO:0001217 | |||||||
Gene_class | ced | ||||||||
Allele (150) | |||||||||
Legacy_information | [C.elegansII] n1892 : programmed cell deaths abnormal, dying cells arrest at highly refractile stage; killer cells fail to engulf target cells; engulfment group A (ced-1,6,7); extensive maternal rescue; no gross phenotype. OA6: n1893, n1896, n1996,n1997, n1998, n2001, n2094.Cloned: encodes 191 kD protein, similarity to ABCtransporter proteins. [Ellis et al. 1991; MT; ZB] | ||||||||
Strain (22) | |||||||||
RNASeq_FPKM (74) | |||||||||
GO_annotation (36) | |||||||||
Ortholog (72) | |||||||||
Paralog | WBGene00000019 | Caenorhabditis elegans | From_analysis | Panther | |||||
WormBase-Compara | |||||||||
WBGene00000020 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
Panther | |||||||||
WormBase-Compara | |||||||||
WBGene00000022 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
Panther | |||||||||
WormBase-Compara | |||||||||
WBGene00000023 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
Panther | |||||||||
WormBase-Compara | |||||||||
Structured_description | Concise_description | ced-7 encodes an ATP binding cassette (ABC) transporter that is a member of the ABCA subfamily of transporter proteins; CED-7 activity is required in both apoptotic and phagocytic cells for engulfment of apoptotic cell corpses; in regulating apoptotic cell clearance, CED-7 functions upstream of CED-10/Rac, and together with CED-1 and CED-6, to mediate actin reorganization around the apoptotic cell corpse in the phagocytic cell; in regulating engulfment with CED-1 and CED-6, CED-7 acts in a pathway parallel to that of CED-2, CED-5, and CED-12; CED-7 localizes to the plasma membrane of many embryonic cells, but in larvae and adults is found in the amphid and phasmid sheath cells and the pharyngeal-intestinal valve; further, CED-7 is expressed in the Z2 and Z3 germline precursor cells and in the germline, except for sperm. | Paper_evidence | WBPaper00003091 | |||||
WBPaper00005200 | |||||||||
WBPaper00025002 | |||||||||
Curator_confirmed | WBPerson1843 | ||||||||
WBPerson567 | |||||||||
Date_last_updated | 07 Mar 2006 00:00:00 | ||||||||
Automated_description | Predicted to enable ATP binding activity; ATPase-coupled transmembrane transporter activity; and lipid transporter activity. Involved in several processes, including engulfment of apoptotic cell; left/right axis specification; and phospholipid efflux. Located in plasma membrane. Expressed in Z2; Z3; germ line; neuronal sheath cell; and pharyngeal-intestinal valve. | Paper_evidence | WBPaper00065943 | ||||||
Curator_confirmed | WBPerson324 | ||||||||
WBPerson37462 | |||||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
Molecular_info | Corresponding_CDS | C48B4.4a | |||||||
C48B4.4b | |||||||||
C48B4.4c | |||||||||
C48B4.4d | |||||||||
Corresponding_transcript | C48B4.4a.1 | ||||||||
C48B4.4a.2 | |||||||||
C48B4.4b.1 | |||||||||
C48B4.4c.1 | |||||||||
C48B4.4d.1 | |||||||||
Other_sequence (33) | |||||||||
Associated_feature | WBsf651383 | ||||||||
WBsf651384 | |||||||||
WBsf667294 | |||||||||
WBsf667295 | |||||||||
WBsf1015629 | |||||||||
WBsf227320 | |||||||||
WBsf227321 | |||||||||
WBsf227322 | |||||||||
WBsf227323 | |||||||||
WBsf227324 | |||||||||
Experimental_info | RNAi_result | WBRNAi00029933 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00042714 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00006973 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00042713 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00066652 | Inferred_automatically | RNAi_primary | |||||||
Expr_pattern | Expr1426 | ||||||||
Expr3316 | |||||||||
Expr1017941 | |||||||||
Expr1030237 | |||||||||
Expr1146706 | |||||||||
Expr2009851 | |||||||||
Expr2028091 | |||||||||
Drives_construct | WBCnstr00011312 | ||||||||
WBCnstr00037555 | |||||||||
Construct_product | WBCnstr00020626 | ||||||||
WBCnstr00037555 | |||||||||
Antibody | WBAntibody00000178 | ||||||||
Microarray_results (35) | |||||||||
Expression_cluster (141) | |||||||||
Interaction (61) | |||||||||
Anatomy_function | WBbtf0061 | ||||||||
WBProcess | WBbiopr:00000013 | ||||||||
WBbiopr:00000014 | |||||||||
WBbiopr:00000015 | |||||||||
Map_info | Map | III | Position | 0.651197 | Error | 0.025749 | |||
Well_ordered | |||||||||
Positive | Inside_rearr | tnDf2 | |||||||
Positive_clone | C29C3 | ||||||||
C48B4 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||||
Mapping_data | Multi_point (16) | ||||||||
Pos_neg_data | 9446 | ||||||||
10531 | |||||||||
10535 | |||||||||
Reference (160) | |||||||||
Method | Gene |