WormBase Tree Display for Gene: WBGene00000411
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| WBGene00000411 | Evidence | CGC_data_submission | |||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | R06F6 | ||||||
| Identity | Version | 1 | |||||||
| Name | CGC_name | cdl-1 | Person_evidence | WBPerson634 | |||||
| Sequence_name | R06F6.1 | ||||||||
| Molecular_name | R06F6.1 | ||||||||
| R06F6.1.1 | |||||||||
| CE51537 | |||||||||
| Other_name | hbp | ||||||||
| CELE_R06F6.1 | Accession_evidence | NDB | BX284602 | ||||||
| Public_name | cdl-1 | ||||||||
| DB_info | Database | AceView | gene | 2L75 | |||||
| WormQTL | gene | WBGene00000411 | |||||||
| WormFlux | gene | WBGene00000411 | |||||||
| NDB | locus_tag | CELE_R06F6.1 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00000411|UniProtKB=Q09599 | |||||||
| family | PTHR17408 | ||||||||
| NCBI | gene | 174659 | |||||||
| RefSeq | protein | NM_063919.8 | |||||||
| SwissProt | UniProtAcc | Q09599 | |||||||
| TREEFAM | TREEFAM_ID | TF316521 | |||||||
| UniProt_GCRP | UniProtAcc | Q09599 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:20 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | cdl | ||||||||
| Allele (37) | |||||||||
| Legacy_information | [A Sugimoto] Cell Death Lethal. w37: (null) zygotic lethal, embryonic arrest with accumulated cell corpses, body elongation defect, pharynx not connected to buccal cavity. e2501, e2510: (possibly neomorphs) similar to w37, but more severe corpse accumulation and elongation defect. | ||||||||
| Strain | WBStrain00022736 | ||||||||
| WBStrain00033878 | |||||||||
| WBStrain00036242 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (16) | |||||||||
| Ortholog (35) | |||||||||
| Structured_description | Concise_description | cdl-1 encodes a homolog of human hairpin (stem-loop) binding proteins (HBP/SLBP) that bind to the hairpin (stem-loop) structure in the 3' untranslated region (3' UTR) of histone mRNAs, and thus promote histone pre-mRNA processing and translation of mature histone mRNA; CDL-1 is required for normally high levels of histone gene expression, normal cell division during late larval development, embryonic viability, normal vulval morphogenesis, normally rapid apoptosis, and fertility; CDL-1 binds to the stem-loop structure in the 3' UTR of core-histone mRNA; the cdl-1 promoter is most active in dividing cells during embryogenesis and postembryonic development; both CDL-1 and human HBP contain a minimal RNA-binding domain (RBD) of roughly 73 amino acids that has no similarity with other known RNA-binding motifs. | Paper_evidence | WBPaper00004428 | |||||
| WBPaper00005085 | |||||||||
| WBPaper00005142 | |||||||||
| WBPaper00013577 | |||||||||
| Person_evidence | WBPerson1874 | ||||||||
| Curator_confirmed | WBPerson13481 | ||||||||
| Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
| Automated_description | Enables mRNA 3'-UTR binding activity. Involved in apoptotic process; embryo development; and mitotic chromosome condensation. Predicted to be located in cytoplasm. Predicted to be part of histone pre-mRNA 3'end processing complex. Expressed widely. Is an ortholog of human SLBP (stem-loop histone mRNA binding protein). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | R06F6.1 | |||||||
| Corresponding_CDS_history | R06F6.1:wp252 | ||||||||
| Corresponding_transcript | R06F6.1.1 | ||||||||
| Other_sequence (18) | |||||||||
| Associated_feature (12) | |||||||||
| Experimental_info | RNAi_result | WBRNAi00082051 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00069364 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00009038 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00008237 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00034665 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00051393 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00026046 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00069365 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00082056 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00086822 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr1840 | ||||||||
| Expr10540 | |||||||||
| Expr1028207 | |||||||||
| Expr1030228 | |||||||||
| Expr1155082 | |||||||||
| Expr2009819 | |||||||||
| Expr2028060 | |||||||||
| Drives_construct | WBCnstr00010480 | ||||||||
| WBCnstr00015525 | |||||||||
| WBCnstr00037562 | |||||||||
| Construct_product | WBCnstr00015525 | ||||||||
| WBCnstr00037562 | |||||||||
| Microarray_results (21) | |||||||||
| Expression_cluster (193) | |||||||||
| Interaction (122) | |||||||||
| WBProcess | WBbiopr:00000014 | ||||||||
| WBbiopr:00000015 | |||||||||
| WBbiopr:00000036 | |||||||||
| WBbiopr:00000098 | |||||||||
| Map_info | Map | II | Position | 3.12577 | Error | 0.000223 | |||
| Well_ordered | |||||||||
| Positive | Positive_clone | R06F6 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| T19E10 | Person_evidence | WBPerson634 | |||||||
| Mapping_data | Multi_point | 4880 | |||||||
| Pos_neg_data | 10583 | ||||||||
| 10584 | |||||||||
| 10585 | |||||||||
| 10586 | |||||||||
| Reference (22) | |||||||||
| Method | Gene |
