WormBase Tree Display for Gene: WBGene00000301
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| WBGene00000301 | SMap | S_parent | Sequence | T13F2 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | cav-1 | Person_evidence | WBPerson464 | |||||
| Sequence_name | T13F2.8 | ||||||||
| Molecular_name | T13F2.8a | ||||||||
| T13F2.8a.1 | |||||||||
| CE13633 | |||||||||
| T13F2.8b | |||||||||
| CE46817 | |||||||||
| T13F2.8b.1 | |||||||||
| Other_name | CELE_T13F2.8 | Accession_evidence | NDB | BX284604 | |||||
| Public_name | cav-1 | ||||||||
| DB_info | Database (12) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:20 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | cav | ||||||||
| Allele (27) | |||||||||
| Possibly_affected_by | WBVar02153186 | ||||||||
| Legacy_information | No mutants known. Encodes predicted 235aa protein, residues 100-235 have 37% identity to mammalian caveolin-1, 32% identity to mammalian caveolin-2, similar properties to mammalian caveolins when expressed in COS cells. 1.4 kb transcript detected, more abundant in eggs. Predicted gene T13F2.8 | ||||||||
| Strain | WBStrain00032372 | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (25) | |||||||||
| Ortholog (41) | |||||||||
| Paralog | WBGene00000302 | Caenorhabditis elegans | From_analysis | TreeFam | |||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | cav-1 encodes one of two C. elegans caveolin orthologs; cav-1 is required for viability and Ras/MAP-kinase-dependent progression through the meiotic cell cycle; CAV-1 is expressed in the adult germ line and during embryonic development; CAV-1::GFP localizes to cortical granules that function to secrete chondroitin and mucin-like proteoglycans to the extracellular space following fertilization. | Paper_evidence | WBPaper00003590 | |||||
| WBPaper00032152 | |||||||||
| Curator_confirmed | WBPerson48 | ||||||||
| WBPerson1843 | |||||||||
| Date_last_updated | 17 Feb 2011 00:00:00 | ||||||||
| Automated_description | Predicted to enable molecular adaptor activity. Involved in Ras protein signal transduction; meiotic cell cycle; and regulation of egg-laying behavior. Located in cytoplasm and cytoplasmic side of plasma membrane. Expressed in several structures, including germ cell; gonad arm; nervous system; pharynx; and tail. Human ortholog(s) of this gene implicated in several diseases, including distal muscular dystrophy Tateyama type; glaucoma (multiple); lipodystrophy (multiple); and systemic scleroderma (multiple). Is an ortholog of human CAV1 (caveolin 1). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model (29) | ||||||||
| Molecular_info | Corresponding_CDS | T13F2.8a | |||||||
| T13F2.8b | |||||||||
| Corresponding_CDS_history | T13F2.8c:wp245 | ||||||||
| Corresponding_transcript | T13F2.8a.1 | ||||||||
| T13F2.8b.1 | |||||||||
| Other_sequence (21) | |||||||||
| Associated_feature (17) | |||||||||
| Experimental_info | RNAi_result (20) | ||||||||
| Expr_pattern (16) | |||||||||
| Drives_construct | WBCnstr00012226 | ||||||||
| WBCnstr00012227 | |||||||||
| WBCnstr00037595 | |||||||||
| WBCnstr00040131 | |||||||||
| Construct_product | WBCnstr00000919 | ||||||||
| WBCnstr00001780 | |||||||||
| WBCnstr00001810 | |||||||||
| WBCnstr00007334 | |||||||||
| WBCnstr00012226 | |||||||||
| WBCnstr00012227 | |||||||||
| WBCnstr00014916 | |||||||||
| WBCnstr00037595 | |||||||||
| WBCnstr00040848 | |||||||||
| Regulate_expr_cluster | WBPaper00054796:cav-1(RNAi)_downregulated | ||||||||
| WBPaper00054796:cav-1(RNAi)_upregulated | |||||||||
| Antibody | WBAntibody00000231 | ||||||||
| WBAntibody00002184 | |||||||||
| WBAntibody00002212 | |||||||||
| WBAntibody00002805 | |||||||||
| Microarray_results (27) | |||||||||
| Expression_cluster (360) | |||||||||
| Interaction (187) | |||||||||
| Map_info | Map | IV | Position | 4.40589 | Error | 0.001071 | |||
| Positive | Positive_clone | T13F2 | Person_evidence | WBPerson464 | |||||
| Author_evidence | Tang Z | ||||||||
| Inferred_automatically | From sequence, transcript, pseudogene data | ||||||||
| Mapping_data | Multi_point | 4175 | |||||||
| Pseudo_map_position | |||||||||
| Reference (38) | |||||||||
| Remark | Data extracted from Tang et al. (1997) | ||||||||
| Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
| Method | Gene |
