[Huang M, Hahn J-H] cah = Cyclase Associated protein Homolog (TU). Sequenced cDNA just 5' to mec-4 has similarity to yeast CAP (cyclase associated protein) gene.
[C.elegansII] pk56 : Tc1 insertion, no known phenotype.Sequenced cDNA just 5' to mec-4 has similarity to yeast CAP (cyclase associated protein) gene. [TU].
cas-1 encodes the C. elegans homologue of the adenylyl cyclase-associated protein 1 (CAP1); as loss of cas-1 activity via large-scale RNAi screens results in no obvious defects, the precise role of cas-1 in C. elegans development and/or behavior is not yet known.
Predicted to enable actin binding activity and adenylate cyclase binding activity. Predicted to be involved in actin filament organization; cAMP-mediated signaling; and cell morphogenesis. Predicted to be located in cytoplasm. Expressed in body wall musculature; intestine; neurons; pharynx; and spermatheca. Human ortholog(s) of this gene implicated in pancreatic cancer. Is an ortholog of human CAP1 (cyclase associated actin cytoskeleton regulatory protein 1) and CAP2 (cyclase associated actin cytoskeleton regulatory protein 2).
This gene was formerly cah-1, renamed at request of J. Hodgkin. krb 01/03/02
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.