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WormBase Tree Display for Gene: WBGene00000294

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Name Class

WBGene00000294SMapS_parentSequenceF41G4
IdentityVersion1
NameCGC_namecas-1Person_evidenceWBPerson95
Sequence_nameF41G4.2
Molecular_nameF41G4.2a
F41G4.2a.1
CE53446
F41G4.2b
CE25885
F41G4.2b.1
Other_namecah-1
CELE_F41G4.2Accession_evidenceNDBBX284606
Public_namecas-1
DB_infoDatabase (11)
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:20WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classcas
Allele (91)
Legacy_information[Huang M, Hahn J-H] cah = Cyclase Associated protein Homolog (TU). Sequenced cDNA just 5' to mec-4 has similarity to yeast CAP (cyclase associated protein) gene.
[C.elegansII] pk56 : Tc1 insertion, no known phenotype.Sequenced cDNA just 5' to mec-4 has similarity to yeast CAP (cyclase associated protein) gene. [TU].
StrainWBStrain00036361
RNASeq_FPKM (74)
GO_annotation00022763
00022764
00022765
00022766
00022767
00022768
00107185
00107186
Ortholog (42)
ParalogWBGene00022028Caenorhabditis elegansFrom_analysisPanther
WBGene00015975Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
Structured_descriptionConcise_descriptioncas-1 encodes the C. elegans homologue of the adenylyl cyclase-associated protein 1 (CAP1); as loss of cas-1 activity via large-scale RNAi screens results in no obvious defects, the precise role of cas-1 in C. elegans development and/or behavior is not yet known.Paper_evidenceWBPaper00002471
WBPaper00005654
WBPaper00025054
Curator_confirmedWBPerson1843
WBPerson480
Date_last_updated18 Oct 2006 00:00:00
Automated_descriptionPredicted to enable actin binding activity and adenylate cyclase binding activity. Predicted to be involved in actin filament organization; cAMP-mediated signaling; and cell morphogenesis. Predicted to be located in cytoplasm. Expressed in body wall musculature; intestine; neurons; pharynx; and spermatheca. Human ortholog(s) of this gene implicated in pancreatic cancer. Is an ortholog of human CAP1 (cyclase associated actin cytoskeleton regulatory protein 1) and CAP2 (cyclase associated actin cytoskeleton regulatory protein 2).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoPotential_modelDOID:1793Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:20040)
DOID:12930Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:20039)
Molecular_infoCorresponding_CDSF41G4.2a
F41G4.2b
Corresponding_CDS_historyF41G4.2a:wp271
Corresponding_transcriptF41G4.2a.1
F41G4.2b.1
Other_sequence (71)
Associated_feature (11)
Experimental_infoRNAi_resultWBRNAi00014773Inferred_automaticallyRNAi_primary
WBRNAi00047027Inferred_automaticallyRNAi_primary
Expr_patternExpr10060
Expr1024557
Expr1030191
Expr1150897
Expr2009722
Expr2027961
Drives_constructWBCnstr00037598
Construct_productWBCnstr00037598
AntibodyWBAntibody00002345
Microarray_results (30)
Expression_cluster (143)
InteractionWBInteraction000029460
WBInteraction000033407
WBInteraction000033409
WBInteraction000033456
WBInteraction000033460
WBInteraction000033969
WBInteraction000035183
WBInteraction000035184
WBInteraction000037785
WBInteraction000037820
WBInteraction000038991
WBInteraction000040218
WBInteraction000045344
WBInteraction000046454
WBInteraction000046754
WBInteraction000048500
WBInteraction000048501
WBInteraction000048502
WBInteraction000048503
WBInteraction000048978
WBInteraction000048979
WBInteraction000050379
WBInteraction000106121
WBInteraction000125719
WBInteraction000149054
WBInteraction000153044
WBInteraction000153045
WBInteraction000153046
WBInteraction000153047
WBInteraction000171167
WBInteraction000185169
WBInteraction000246472
WBInteraction000250785
WBInteraction000264789
WBInteraction000264790
WBInteraction000264791
WBInteraction000264792
WBInteraction000264793
WBInteraction000277488
WBInteraction000293122
WBInteraction000293645
WBInteraction000299729
WBInteraction000315464
WBInteraction000321836
WBInteraction000330882
WBInteraction000339643
WBInteraction000350483
WBInteraction000365598
WBInteraction000390298
WBInteraction000403567
WBInteraction000408613
WBInteraction000413461
WBInteraction000416325
WBInteraction000424633
WBInteraction000431352
WBInteraction000439186
WBInteraction000445176
WBInteraction000447252
WBInteraction000465739
WBInteraction000466707
WBInteraction000472718
WBInteraction000472719
WBInteraction000518632
WBInteraction000541311
WBInteraction000541327
WBInteraction000541344
WBInteraction000541365
WBInteraction000546406
WBInteraction000546729
WBInteraction000546807
WBInteraction000551444
WBInteraction000553064
WBInteraction000561481
WBInteraction000563700
WBInteraction000566136
WBInteraction000574231
WBInteraction000574588
WBInteraction000576067
WBInteraction000577496
WBInteraction000579875
WBInteraction000582072
Map_infoMapXPosition24.0631Error0.00011
PositivePositive_cloneF41G4Inferred_automaticallyFrom sequence, transcript, pseudogene data
T20B9
Pseudo_map_position
ReferenceWBPaper00002471
WBPaper00038491
WBPaper00041203
WBPaper00042407
WBPaper00055090
RemarkThis gene was formerly cah-1, renamed at request of J. Hodgkin. krb 01/03/02
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene