WormBase Tree Display for Gene: WBGene00000253
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| WBGene00000253 | Evidence | CGC_data_submission | |||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | CHROMOSOME_I | ||||||
| Identity | Version | 2 | |||||||
| Name | CGC_name | bli-3 | Person_evidence | WBPerson261 | |||||
| Sequence_name | F56C11.1 | ||||||||
| Molecular_name | F56C11.1 | ||||||||
| F56C11.1.1 | |||||||||
| CE28463 | |||||||||
| F56C11.1.2 | |||||||||
| Other_name | tag-31 | CGC_data_submission | |||||||
| duox-1 | Paper_evidence | WBPaper00004841 | |||||||
| WBPaper00006395 | |||||||||
| Person_evidence | WBPerson56 | ||||||||
| CELE_F56C11.1 | Accession_evidence | NDB | BX284601 | ||||||
| Public_name | bli-3 | ||||||||
| DB_info | Database (13) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:20 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| 2 | 07 Sep 2009 12:21:16 | WBPerson9133 | Name_change | CGC_name | duox-1 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | bli | ||||||||
| Reference_allele | WBVar00143469 | ||||||||
| Allele (139) | |||||||||
| Legacy_information | e767 : small irregular shape variable slight blistering in adult. ES2 (adult late larvae) ME1. NA1. | ||||||||
| See also e767, n529 | |||||||||
| [C.elegansII]e767 : small irregular shape variable slight blistering in adult. ES2 (adult late larvae) ME1. OA1: n529. [Brenner 1974; CB] | |||||||||
| Strain | WBStrain00005170 | ||||||||
| WBStrain00005171 | |||||||||
| WBStrain00005172 | |||||||||
| WBStrain00005173 | |||||||||
| WBStrain00026799 | |||||||||
| WBStrain00026835 | |||||||||
| WBStrain00027251 | |||||||||
| WBStrain00028999 | |||||||||
| WBStrain00037731 | |||||||||
| WBStrain00004204 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (36) | |||||||||
| Ortholog (42) | |||||||||
| Paralog | WBGene00018771 | Caenorhabditis elegans | From_analysis | TreeFam | |||||
| Inparanoid_8 | |||||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | bli-3 encodes an NADPH oxidases of the dual oxidase (DUOX) variety that contains an N-terminal peroxidase domain, two central calmodulin-binding EF hands, and a C-terminal superoxide-generating NADPH-oxidase domain; BLI-3 is required for dityrosine cross-linking of collagen, and thus for cuticular integrity; BLI-3 is thought to use cytosolic NADPH to generate reactive oxygen, which then drives the peroxidase ectodomain to cross-link free tyrosine in collagen; BLI-3 is expressed exclusively in hypodermal cells at low levels, with peaks of expression corresponding to collagen/cuticle biosynthesis. | Paper_evidence | WBPaper00000031 | |||||
| WBPaper00002665 | |||||||||
| WBPaper00004841 | |||||||||
| WBPaper00005747 | |||||||||
| WBPaper00033104 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 19 Aug 2009 00:00:00 | ||||||||
| Automated_description | Enables NAD(P)H oxidase H2O2-forming activity; heme binding activity; and peroxidase activity. Involved in several processes, including cuticle development involved in collagen and cuticulin-based cuticle molting cycle; defense response to other organism; and post-embryonic development. Located in plasma membrane. Expressed in hypodermis; intestine; and neurons. Used to study phenylketonuria. Human ortholog(s) of this gene implicated in cholera; inflammatory bowel disease (multiple); and thyroid dyshormonogenesis 6. Is an ortholog of human DUOX2 (dual oxidase 2). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Experimental_model | DOID:9281 | |||||||
| Potential_model | DOID:0050328 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:13273) | |||||
| DOID:8577 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:13273) | ||||||
| DOID:1498 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:13273) | ||||||
| DOID:8778 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:13273) | ||||||
| DOID:0112189 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:13273) | ||||||
| Models_disease_asserted | WBDOannot00000626 | ||||||||
| Molecular_info | Corresponding_CDS | F56C11.1 | |||||||
| Corresponding_transcript | F56C11.1.1 | ||||||||
| F56C11.1.2 | |||||||||
| Other_sequence (17) | |||||||||
| Associated_feature | WBsf717434 | ||||||||
| WBsf982412 | |||||||||
| WBsf982413 | |||||||||
| WBsf982414 | |||||||||
| WBsf1009036 | |||||||||
| WBsf218873 | |||||||||
| WBsf218874 | |||||||||
| Experimental_info | RNAi_result (35) | ||||||||
| Expr_pattern | Expr2613 | ||||||||
| Expr15757 | |||||||||
| Expr1010236 | |||||||||
| Expr1030163 | |||||||||
| Expr1152411 | |||||||||
| Expr2009629 | |||||||||
| Expr2027868 | |||||||||
| Drives_construct | WBCnstr00021138 | ||||||||
| WBCnstr00037626 | |||||||||
| WBCnstr00042508 | |||||||||
| Construct_product | WBCnstr00015484 | ||||||||
| WBCnstr00015485 | |||||||||
| WBCnstr00015489 | |||||||||
| WBCnstr00015491 | |||||||||
| WBCnstr00037626 | |||||||||
| Antibody | WBAntibody00000404 | ||||||||
| WBAntibody00002391 | |||||||||
| WBAntibody00002392 | |||||||||
| Microarray_results (21) | |||||||||
| Expression_cluster (114) | |||||||||
| Interaction (22) | |||||||||
| WBProcess | WBbiopr:00000039 | ||||||||
| WBbiopr:00000096 | |||||||||
| Map_info | Map | I | Position | -19.1485 | Error | 0.002825 | |||
| Well_ordered | |||||||||
| Positive | Inside_rearr | sDp2 | |||||||
| Positive_clone | F56C11 | Inferred_automatically | From sequence, transcript, pseudogene data | ||||||
| Mapping_data | 2_point | 1 | |||||||
| 2504 | |||||||||
| 3941 | |||||||||
| 4741 | |||||||||
| 6080 | |||||||||
| 7166 | |||||||||
| 7167 | |||||||||
| 7169 | |||||||||
| Multi_point (18) | |||||||||
| Pos_neg_data | 6276 | ||||||||
| 1026 | |||||||||
| 955 | |||||||||
| 4553 | |||||||||
| 4554 | |||||||||
| 4555 | |||||||||
| 4556 | |||||||||
| Landmark_gene | |||||||||
| Reference (58) | |||||||||
| Remark | Gene name created from parsing 'genotype' field from CGC strain information | CGC_data_submission | |||||||
| Method | Gene |
