WormBase Tree Display for Gene: WBGene00000206

WBGene00000206 SMap: S_parent: Sequence: F35G12
  Identity: Version: 1
    Name: CGC_name: asb-1 Person_evidence: WBPerson284
      Sequence_name: F35G12.10
      Molecular_name: F35G12.10
        F35G12.10.1
        CE00968
      Other_name: CELE_F35G12.10 Accession_evidence: NDB BX284603
      Public_name: asb-1
    DB_info: Database: AceView gene 3F686
        WormQTL gene WBGene00000206
        WormFlux gene WBGene00000206
        NDB locus_tag CELE_F35G12.10
        Panther gene CAEEL|WormBase=WBGene00000206|UniProtKB=Q20053
          family PTHR12733
        NCBI gene 175605
        RefSeq protein NM_065537.7
        SwissProt UniProtAcc Q20053
        TREEFAM TREEFAM_ID TF313250
        UniProt_GCRP UniProtAcc Q20053
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:20 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: asb
    Allele (11)
    Strain: WBStrain00022689
      WBStrain00022690
    RNASeq_FPKM (74)
    GO_annotation (17)
    Contained_in_operon: CEOP3204
    Ortholog (37)
    Paralog: WBGene00000207 Caenorhabditis elegans From_analysis: Inparanoid_8
            Panther
            WormBase-Compara
    Structured_description: Concise_description: asb-1 encodes the B subunit of the membrane-bound F0 proton channel portion of ATP synthase (mitochondrial respiratory chain [MRC] complex V) that is closely similar to its paralog ASB-2; asb-1 activity is required for embryonic viability and for normal proliferation of germline cells, specifically their progression to meiosis; in addition, asb-1 is required for response to hermaphrodite contact, the first step in a series of stereotypical male mating behaviors; expression of asb-1 mRNA is enriched in the germline and an ASB-1::GFP fusion localizes to mitochondria and to cilia of the male-specific CEM neurons. Paper_evidence: WBPaper00005486
            WBPaper00024944
          Curator_confirmed: WBPerson1843
            WBPerson567
          Date_last_updated: 17 Jan 2007 00:00:00
      Automated_description: Predicted to enable proton transmembrane transporter activity. Predicted to contribute to proton-transporting ATP synthase activity, rotational mechanism. Predicted to be involved in proton motive force-driven ATP synthesis. Located in mitochondrion and non-motile cilium. Expressed in germ line. Human ortholog(s) of this gene implicated in clear cell renal cell carcinoma and hepatocellular carcinoma. Is an ortholog of human ATP5PB (ATP synthase peripheral stalk-membrane subunit b). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:4467 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:840)
      DOID:684 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:840)
  Molecular_info: Corresponding_CDS: F35G12.10
    Corresponding_transcript: F35G12.10.1
    Other_sequence (16)
    Associated_feature: WBsf666804
      WBsf226553
      WBsf226554
      WBsf226555
  Experimental_info: RNAi_result (24)
    Expr_pattern: Expr4494
      Expr4496
      Expr4498
      Expr1018693
      Expr1030125
      Expr1150264
      Expr2009443
      Expr2027680
    Drives_construct: WBCnstr00037665
    Construct_product: WBCnstr00004944
      WBCnstr00037665
    Microarray_results (22)
    Expression_cluster: WBPaper00031040:TGF-beta_adult_downregulated
      WBPaper00037047:insoluble_protein
      WBPaper00037086:biotin_regulated
      WBPaper00037950:AVE-neuron_L1-larva_expressed
      WBPaper00037950:BAG-neuron_blastula-embryo_expressed
      WBPaper00037950:BAG-neuron_embryo_enriched
      WBPaper00037950:BAG-neuron_embryo_SelectivelyEnriched
      WBPaper00037950:bodywall-muscle_L2-larva_expressed
      WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed
      WBPaper00037950:germline-precursors_blastula-embryo_expressed
      WBPaper00037950:germline-precursors_embryo_enriched
      WBPaper00037950:germline-precursors_embryo_SelectivelyEnriched
      WBPaper00038289:oocyte_protein
      WBPaper00040965:lipid-droplet_associated_protein
      WBPaper00044501:gld-1_let-7_regulated
      WBPaper00044656:tatn-1(qd182)_downregulated
      WBPaper00044736:flat_dev_expression
      WBPaper00044746:aging_upregulated_Day5
      WBPaper00044746:aging_upregulated_HeatShock
      WBPaper00044760:germline_specific
      WBPaper00045521:Gender_Neutral
      WBPaper00045571:germline-ablation_downregulated
      WBPaper00046337:monosomal_N2_vs_daf-2_upregulated
      WBPaper00046446:rapid-synthesized_AgingAdult
      WBPaper00048611:MnCl2_downregulated
      WBPaper00048923:Aging_regulated
      WBPaper00048988:neuron_expressed
      WBPaper00049545:jmjd-3.1(+)_downregulated
      WBPaper00049954:BPS_downregulated
      WBPaper00050015:ifg-1(RNAi)_downregulated
      WBPaper00050344:AFD-neuron_enriched
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050522:mafr-1(tm6082)_downregulated
      WBPaper00050686:glp-1(e2141)_downregulated
      WBPaper00050698:DEP-1_interacting
      WBPaper00050726:OsmoticStress_regulated_Food
      WBPaper00050726:starvation_regulated_LowSalt
      WBPaper00050859:downregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050990:hypodermis_expressed
      WBPaper00050990:intestine_expressed
      WBPaper00050990:NMDA-neuron_expressed
      WBPaper00050990:seam_expressed
      WBPaper00051039:germline_enriched
      WBPaper00051245:body-wall-muscle_cytoplasm_expressed
      WBPaper00051245:body-wall-muscle_nucleus_expressed
      WBPaper00051245:epidermis_cytoplasm_expressed
      WBPaper00051245:epidermis_nucleus_expressed
      WBPaper00051245:intestine_cytoplasm_expressed
      WBPaper00051245:intestine_nucleus_expressed
      WBPaper00051311:VGLN-1-interacting
      WBPaper00051558:aging_regulated
      WBPaper00051558:fog-2(q71)_regulated
      WBPaper00052884:emb-4(hc60)_downregulated
      WBPaper00053184:sma-2(rax5)_downregulated
      WBPaper00053184:sma-4(rax3)_downregulated
      WBPaper00053295:lin-22(icb38)_downregulated
      WBPaper00053295:lin-22(ot269)_downregulated
      WBPaper00053302:zidovudine_72h_regulated
      WBPaper00053321:PGCs_enriched_NuGen
      WBPaper00053388:dauer_regulated_Cluster2
      WBPaper00053615:SMO-1_target
      WBPaper00053810:daf-2(e1370)_downregulated
      WBPaper00053810:nuo-6(qm200)_downregulated
      WBPaper00055354:Rifampicin-Allantoin_upregulated
      WBPaper00055482:pmt-2(RNAi)_downregulated
      WBPaper00055648:germline_expressed
      WBPaper00055862:antimycin_damt-1(gk961032)_regulated
      WBPaper00056034:pals-22(jy3)_downregulated
      WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047)
      WBPaper00056090:E.faecalis_downregulated_N2
      WBPaper00056161:male_enriched_siRNA
      WBPaper00056443:sek-1(km4)_downregulated
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_downregulated
      WBPaper00056471:S.aureus-4h_downregulated_N2
      WBPaper00056501:P.aeruginosa_upregulated_mitochondria-protein
      WBPaper00056809:smn-1(ok355)_downregulated
      WBPaper00056826:SGP_biased
      WBPaper00057041:spc-1(cas971)_upregulated
      WBPaper00057041:unc-70(cas983)_upregulated
      WBPaper00057288:iff-1(RNAi)_downregulated_transcript
      WBPaper00058598:mex-1(or286)_downregulated
      WBPaper00058598:mex-3(eu149)_downregulated
      WBPaper00058598:sin-3(tm1276)_upregulated
      WBPaper00058948:PA14_upregulated
      WBPaper00059328:mrps-5(RNAi)_downregulated_protein
      WBPaper00059567:olrn-1(ums9)_regulated
      WBPaper00059664:srbc-48(ac23)_downregulated
      WBPaper00060014:set-2(tm1630)_upregulated
      WBPaper00060100:SiNP_downregulated_mRNA
      WBPaper00060661:sensory-neuron_depleted
      WBPaper00060811:L1_vs_adult_downregulated_neural
      WBPaper00060909:atfs-1(cmh15)_upregulated
      WBPaper00061045:Y56A3A.22(cck200)_downregulated
      WBPaper00061203:sin-3(tm1276)_downregulated
      WBPaper00061203:spr-1(ok2144)_downregulated
      WBPaper00061341:28C_24h_downregulated
      WBPaper00061341:28C_48h_downregulated
      WBPaper00061377:MYRF-2_interacting
      WBPaper00061466:nath-10(icb102)_upregulated
      WBPaper00061478:SUMO-conjugated_protein
      WBPaper00061527:T22D1.5-inx-14
      WBPaper00061651:Germline_enriched
      WBPaper00062159:hda-2(ok1479)_downregulated
      WBPaper00062456:doxycycline_downregulated_CB4856_protein
      WBPaper00062498:PPM-1.D_interacting
      WBPaper00062554:MAGU-2_interacting
      WBPaper00062669:extracellular-vesicle_protein
      WBPaper00064055:trl-1(cas1077)_downregulated_starved
      WBPaper00064071:NHR-49_interacting
      WBPaper00064088:Day-1-adult_vs_L4_upregulated_fem-3(q20)
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_fem-3(q20)
      WBPaper00064201:SNA-3_interacting
      WBPaper00064315:mes-4(bn73)_downregulated_EGCs
      WBPaper00064315:mrg-1(qa6200)_downregulated_PGCs
      WBPaper00064716:paraquat_upregulated
      WBPaper00065120:body-muscle-transcriptome
      WBPaper00065158:AFD_depleted
      WBPaper00065373:Cisplatin_upregulated_WT
      WBPaper00065975:P-body_vs_oocyte_depleted
      WBPaper00065993:glp-1(e2141)_downregulated
      WBPaper00066146:germline-inx-14(RNAi)_downregulated_PA14
      cgc4386_cluster_4_2
      cgc4489_group_2
      WBPaper00025032:cluster_3
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00025141:unc-4::GFP_Expressed_Genes
      WBPaper00026929:sir-2.1_overexpression_regulated
      WBPaper00027342:alpha-Synuclein(WT)_upregulated
      WBPaper00031060:2-deoxy-D-glucose_downregulated
      WBPaper00032165:differentially_expressed_with_age_medoid_7
      WBPaper00032948:FedUp
      WBPaper00036286:Pattern_H
      WBPaper00036375:depleted_in_PVD_OLL
      WBPaper00040426:CYD-1_CDK-4_upregulated
      WBPaper00040426:CYE-1_CDK-2AF_upregulated
      WBPaper00040858:eQTL_regulated_juvenile
      WBPaper00041606:CE_B.thuringiensis-DB27_regulated
      WBPaper00041606:CE_S.marcescens_regulated
      WBPaper00041606:CE_X.nematophila_regulated
      WBPaper00041939:control_vs_EtBr-exposed_48h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_51h
      WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00041939:UVC-EtBr-exposed_vs_EtBr-exposed_51h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_51h
      WBPaper00045263:nuo-6(qm200)_downregulated
      WBPaper00047070:N2_starvation_downregulated
      WBPaper00048989:eat-2(ad465)_rapamycin_upregulated
      WBPaper00053236:Starvation_regulated_GR1307
      WBPaper00053236:Starvation_regulated_N2
      [cgc5767]:cluster_22
      [cgc5767]:expression_class_M
      [cgc5767]:expression_class_MD
      [cgc5767]:expression_class_MD_pd(23_min)
      [cgc5767]:expression_class_SM
      [cgc5767]:expression_class_SMD
      [cgc6390]:Cluster_E
      [cgc6390]:intrinsic
    Interaction (213)
    WBProcess: WBbiopr:00000012
  Map_info: Map: III Position: -3.03261 Error: 0.002151
    Positive: Positive_clone: F35G12 Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference (14)
  Remark: Sequence connection from [Iino Y]
    Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene