WormBase Tree Display for Gene: WBGene00000203

WBGene00000203 Evidence: Paper_evidence: WBPaper00005843
  SMap: S_parent: Sequence: CHROMOSOME_III
  Identity: Version: 1
    Name: CGC_name: arx-5 Person_evidence: WBPerson633
      Sequence_name: Y37D8A.1
      Molecular_name: Y37D8A.1
        Y37D8A.1.1
        CE20206
      Other_name: CELE_Y37D8A.1 Accession_evidence: NDB BX284603
      Public_name: arx-5
    DB_info: Database: AceView gene 3N906
        WormQTL gene WBGene00000203
        WormFlux gene WBGene00000203
        NDB locus_tag CELE_Y37D8A.1
        Panther gene CAEEL|WormBase=WBGene00000203|UniProtKB=Q9XWV3
          family PTHR12391
        NCBI gene 176697
        RefSeq protein NM_067266.4
        SwissProt UniProtAcc Q9XWV3
        TREEFAM TREEFAM_ID TF314598
        UniProt_GCRP UniProtAcc Q9XWV3
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:20 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: arx
    Allele (16)
    Strain: WBStrain00037079
    RNASeq_FPKM (74)
    GO_annotation (15)
    Ortholog (39)
    Structured_description: Concise_description: arx-5 also called as p21Arc encodes a subunit of the actin related protein of the conserved Arp2/3 complex, with 60% amino acid similarity with the homologous genes from human (OMIM: 604225); arx-5 is an essential gene as disruption in the expression by RNAi results in embryonic arrest due to ventral enclosure during morphogenesis; Arp2/3 depletion results in partial shrinking of the Ea/p apical surfaces and incomplete Ea/p cell internalization; WSP-1 activates Arp2/3 complex and their function in ventral enclosure is cell autonomous; Arp2/3 regulates some Apical Junction components in embryos and adults; Arp2/3 is required during intestinal morphogenesis for regulation of intestinal lumen width in embryos and apical F-actin accumulation during larval and adult growth. Paper_evidence: WBPaper00005843
            WBPaper00035433
          Curator_confirmed: WBPerson12884
            WBPerson1843
          Date_last_updated: 10 Aug 2011 00:00:00
      Automated_description: Predicted to enable actin binding activity. Predicted to contribute to actin filament binding activity. Involved in epithelial cell migration and morphogenesis of embryonic epithelium. Located in striated muscle dense body. Human ortholog(s) of this gene implicated in diabetes mellitus. Is an ortholog of human ARPC3 (actin related protein 2/3 complex subunit 3). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:9351 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:706)
  Molecular_info: Corresponding_CDS: Y37D8A.1
    Corresponding_transcript: Y37D8A.1.1
    Other_sequence (39)
    Associated_feature: WBsf227685
      WBsf227686
  Experimental_info: RNAi_result (25)
    Expr_pattern: Expr8838
      Expr9399
      Expr1018806
      Expr1030122
      Expr1159393
      Expr2009438
      Expr2027675
    Drives_construct: WBCnstr00037667
    Construct_product: WBCnstr00013964
      WBCnstr00019218
      WBCnstr00037667
    Antibody: WBAntibody00002051
    Microarray_results (19)
    Expression_cluster: WBPaper00031040:TGF-beta_adult_downregulated
      WBPaper00037950:A-class-motor-neurons_L2-larva_expressed
      WBPaper00037950:all-neurons_L2-larva_expressed
      WBPaper00037950:AVE-neuron_L1-larva_expressed
      WBPaper00037950:bodywall-muscle_L2-larva_expressed
      WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed
      WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
      WBPaper00037950:excretory-cell_L2-larva_expressed
      WBPaper00037950:hypodermis_L3-L4-larva_expressed
      WBPaper00037950:intestine_L1-larva_expressed
      WBPaper00037950:intestine_L2-larva_expressed
      WBPaper00037950:intestine_larva_enriched
      WBPaper00037950:intestine_larva_SelectivelyEnriched
      WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
      WBPaper00038289:oocyte_protein
      WBPaper00044501:gld-1_let-7_regulated
      WBPaper00044736:flat_dev_expression
      WBPaper00045521:Gender_Neutral
      WBPaper00045974:NSM_enriched_DSN-treated_RNAseq
      WBPaper00048988:neuron_expressed
      WBPaper00049177:rpn-10(ok1865)_upregulated
      WBPaper00049498:npr-1(ur89)_regulated_3
      WBPaper00049545:jmjd-3.1(+)_downregulated
      WBPaper00049545:sur-5p-jmjd-1.2(+)_downregulated
      WBPaper00050344:ASER-neuron_enriched
      WBPaper00050468:hlh-30-dependent_Cry5B_regulated
      WBPaper00050488:20C_vs_25C_regulated_N2_adult
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050488:mir-34(OverExpression)_vs_N2_regulated_adult_20C
      WBPaper00050726:OsmoticStress_regulated_Food
      WBPaper00050990:GABAergic-neuron_expressed
      WBPaper00050990:intestine_expressed
      WBPaper00050990:pharynx_expressed
      WBPaper00051039:germline_enriched
      WBPaper00052884:emb-4(hc60)_downregulated
      WBPaper00053184:sma-2(rax5)_downregulated
      WBPaper00053184:sma-4(rax3)_downregulated
      WBPaper00053302:zidovudine_24h_regulated
      WBPaper00055648:germline_expressed
      WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047)
      WBPaper00056617:adr-2(gv42)_downregulated_L4_protein
      WBPaper00057288:iff-1(RNAi)_downregulated_transcript
      WBPaper00058598:sin-3(tm1276)_downregulated
      WBPaper00058691:cfp-1(tm6369)_upregulated
      WBPaper00058691:set-2(bn129)_upregulated
      WBPaper00061203:sin-3(tm1276)_upregulated
      WBPaper00061527:pbs-3_18439-rpn-5
      WBPaper00062669:extracellular-vesicle_protein
      WBPaper00064005:starvation_downregulated_N2_mRNA
      WBPaper00064071:NHR-49_interacting
      WBPaper00064494:postdauer_upregulated_AWA
      WBPaper00064716:paraquat_upregulated
      WBPaper00065258:anchor-cell_enriched
      WBPaper00065373:Cisplatin_upregulated_WT
      cgc4489_group_7
      WBPaper00025032:cluster_109
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00025141:unc-4::GFP_Expressed_Genes
      WBPaper00026929:sir-2.1_overexpression_regulated
      WBPaper00026980:intestine_enriched
      WBPaper00030839:Embryo_Pan_Neuronal
      WBPaper00032165:differentially_expressed_with_age_medoid_5
      WBPaper00032948:FedUp
      WBPaper00035905:FBF-1_Associated
      WBPaper00036286:Pattern_F
      WBPaper00040210:Chlorpyrifos_Diazinon_24C_regulated
      WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2
      WBPaper00041606:CE_X.nematophila_regulated
      WBPaper00041939:control_vs_EtBr-exposed_48h
      WBPaper00048989:eat-2(ad465)_rapamycin_upregulated
      WBPaper00053236:Starvation_regulated_N2
      [cgc5767]:cluster_14
      [cgc5767]:expression_class_E
      [cgc5767]:expression_class_E_pi(23_min)
      [cgc5767]:expression_class_M
      [cgc5767]:expression_class_MD
      [cgc5767]:expression_class_MDE
      [cgc5767]:expression_class_MD_pd(23_min)
      [cgc5767]:expression_class_ME
    Interaction (43)
  Map_info: Map: III Position: 19.0426 Error: 0.030817
    Positive: Positive_clone: Y37D8A Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference: WBPaper00005843
    WBPaper00024200
    WBPaper00031805
    WBPaper00035433
    WBPaper00038444
    WBPaper00038491
    WBPaper00046168
    WBPaper00055090
    WBPaper00058387
    WBPaper00063976
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene