| WBGene00000140 | SMap | S_parent | Sequence | CHROMOSOME_I |
|---|
| Identity | Version | 1 |
| | Name | CGC_name | anc-1 | Person_evidence | WBPerson261 |
| | | Sequence_name | ZK973.6 |
| | | Molecular_name | ZK973.6a |
| | | | ZK973.6a.1 |
| | | | CE33588 |
| | | | ZK973.6b |
| | | | CE52283 |
| | | | ZK973.6c |
| | | | CE52179 |
| | | | ZK973.6b.1 |
| | | | ZK973.6c.1 |
| | | Other_name | T03A1.a | Curator_confirmed | WBPerson1983 |
| | | | | Remark | Old cosmid naming mapped via unique overlapping PCR_product on CDSs |
| | | | T03A1.c | Curator_confirmed | WBPerson1983 |
| | | | | Remark | Old cosmid naming mapped via unique overlapping PCR_product on CDSs |
| | | | CELE_ZK973.6 | Accession_evidence | NDB | BX284601 |
| | | Public_name | anc-1 |
| | DB_info | Database (11) |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:20 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | Status | Live |
| Gene_info (13) |
| Disease_info | Experimental_model | DOID:11726 | Homo sapiens | Paper_evidence | WBPaper00040268 |
| | | | | Accession_evidence | OMIM | 612998 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | Date_last_updated | 14 Feb 2013 00:00:00 |
| | Potential_model | DOID:3312 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:17089) |
| | | DOID:0070249 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:17089) |
| | | DOID:9884 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:17089) |
| | | DOID:0070250 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:17084) |
| | | DOID:0080954 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:17089) |
| | | DOID:0050753 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:17089) |
| | | DOID:0080979 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:17089) |
| | | DOID:0111618 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:17089) |
| | Disease_relevance | The human ortholog of anc-1, SYNE1 (spectrin repeat containing, nuclear envelope 1) encodes for the Nesprin 1 protein; mutations in SYNE1, similar to those in LMNA/Lamin, cause laminopathic diseases like Emery-Dreifuss muscular dystrophy (EDMD) and Spinocerebellar ataxia; Nesprin 1 belongs to the family of mammalian KASH domain proteins; vertebrates have Nesprin-1/SYNE1, Nesprin-2/SYNE2, Nesprin-3/SYNE3 and Nesprin-4/SYNE4) that encode at least 12 isoforms, by alternative transcription and splicing; KASH-domain proteins along with SUN-domain proteins form a LINC (linker of nucleoskeleton and cytoskeleton) complex which links components of the nucleus with the cytoplasm; studies in elegans show that anc-1 interacts with actin and is involved in nuclear positioning and migration; anc-1 requires the SUN domain protein UNC-84, orthologous to mammalian SUN1 and SUN2 proteins, for its nuclear localization. | Homo sapiens | Paper_evidence | WBPaper00040268 |
| | | | | Accession_evidence | OMIM | 612998 |
| | | | | | | 610743 |
| | | | | | | 608441 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | Date_last_updated | 09 Mar 2012 00:00:00 |
| Modifies_disease | DOID:070355 |
| Models_disease_in_annotation | WBDOannot00000048 |
| Modifies_disease_in_annotation | WBDOannot00001302 |
| Molecular_info | Corresponding_CDS | ZK973.6a |
| | | ZK973.6b |
| | | ZK973.6c |
| | Corresponding_CDS_history | ZK973.6:wp96 |
| | Corresponding_transcript | ZK973.6a.1 |
| | | ZK973.6b.1 |
| | | ZK973.6c.1 |
| | Other_sequence (97) |
| | Associated_feature (28) |
| Experimental_info | RNAi_result (28) |
| | Expr_pattern | Chronogram1817 |
| | | Expr2219 |
| | | Expr2220 |
| | | Expr12539 |
| | | Expr1027397 |
| | | Expr1030073 |
| | | Expr1163298 |
| | | Expr2009333 |
| | | Expr2027569 |
| | Drives_construct | WBCnstr00003410 |
| | Construct_product | WBCnstr00010709 |
| | Regulate_expr_cluster | WBPaper00060317:anc-1(RNAi)_downregulated |
| | | WBPaper00060317:anc-1(RNAi)_upregulated |
| | Antibody | WBAntibody00000559 |
| | Microarray_results (43) |
| | Expression_cluster | WBPaper00029359_1182 |
| | | WBPaper00029359_1444 |
| | | WBPaper00029359_1504 |
| | | WBPaper00029359_1678 |
| | | WBPaper00032031:DConiospora_downregulated_OligoArray_24h |
| | | WBPaper00033065:cyc-1(RNAi)_upregulated |
| | | WBPaper00035073:mitochondria_protein |
| | | WBPaper00037055:DAF-16_binding_DNA |
| | | WBPaper00037946:LIN-39_interacting |
| | | WBPaper00037950:all-neurons_embryo_enriched |
| | | WBPaper00037950:all-neurons_L1-larva_expressed |
| | | WBPaper00037950:AVA-neuron_L1-larva_expressed |
| | | WBPaper00037950:BAG-neuron_blastula-embryo_expressed |
| | | WBPaper00037950:bodywall-muscle_L1-larva_expressed |
| | | WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed |
| | | WBPaper00037950:coelomocytes_L1-larva_expressed |
| | | WBPaper00037950:dopaminergic-neurons_L1-larva_expressed |
| | | WBPaper00037950:GABAergic-motor-neurons_L1-larva_expressed |
| | | WBPaper00037950:hypodermis_L3-L4-larva_expressed |
| | | WBPaper00037950:pharyngeal-muscle_L1-larva_expressed |
| | | WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed |
| | | WBPaper00038118:aak-2(gt33)_upregulated |
| | | WBPaper00038289:oocyte_protein |
| | | WBPaper00038438:D.coniospora_12hr_downregulated_RNAseq |
| | | WBPaper00040285:H2S_12hr_downregulated |
| | | WBPaper00043951:insoluble_protein_day16_N2 |
| | | WBPaper00044128:DietaryRestriction_upregulated |
| | | WBPaper00044426:rotenone_24h_upregulated |
| | | WBPaper00044578:4-day_reduced-humidity_upregulated_proteomics |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00044746:aging_downregulated_Day5 |
| | | WBPaper00044746:aging_downregulated_HeatShock |
| | | WBPaper00045316:prg-1_upregulated_L4 |
| | | WBPaper00045521:Spermatogenic |
| | | WBPaper00045565:BIR-1_induced |
| | | WBPaper00045571:germline-ablation_upregulated |
| | | WBPaper00045774:clk-1_upregulated |
| | | WBPaper00045934:wrn-1(gk99)_upregulated |
| | | WBPaper00046217:clk-1(qm30)_upregulated |
| | | WBPaper00046497:B.thuringiensis_0.1mix_downregulated_12h |
| | | WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h |
| | | WBPaper00048910:Apoptosis-induced_mRNA-interacting_protein |
| | | WBPaper00048910:mRNA-interacting_protein |
| | | WBPaper00048971:daf-16(mgDf50)_downregulated_L1 |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049377:MWCNT_upregulated |
| | | WBPaper00049545:jmjd-3.1(+)_downregulated |
| | | WBPaper00050344:AFD-neuron_enriched |
| | | WBPaper00050344:ASER-neuron_enriched |
| | | WBPaper00050468:hlh-30-dependent_Cry5B_regulated |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050636:aging_regulated_insoluble_protein |
| | | WBPaper00050726:OsmoticStress_regulated_Food |
| | | WBPaper00050843:sesamin_downregulated |
| | | WBPaper00050859:upregulated_glh-1(gk100)_vs_control_day1-adult |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day1-adult |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult |
| | | WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult |
| | | WBPaper00050990:arcade_intestinal-valve_expressed |
| | | WBPaper00050990:body-muscle_expressed |
| | | WBPaper00050990:GABAergic-neuron_expressed |
| | | WBPaper00050990:hypodermis_expressed |
| | | WBPaper00050990:intestine_expressed |
| | | WBPaper00050990:NMDA-neuron_expressed |
| | | WBPaper00050990:pharynx_expressed |
| | | WBPaper00050990:seam_expressed |
| | | WBPaper00051039:ash-2(RNAi)_regulated_intestine |
| | | WBPaper00051039:intestine_enriched |
| | | WBPaper00051245:body-wall-muscle_cytoplasm_expressed |
| | | WBPaper00051245:cytoplasm_specific |
| | | WBPaper00051245:epidermis_cytoplasm_expressed |
| | | WBPaper00051245:intestine_cytoplasm_expressed |
| | | WBPaper00051245:pharyngeal-muscle_cytoplasm_expressed |
| | | WBPaper00051265:F4_hrde-1(tm1200)_upregulated |
| | | WBPaper00051310:LIN-41_interacting |
| | | WBPaper00051461:pig-1(gm344)_downregulated |
| | | WBPaper00051538:micro-gavity_downregulated_protein |
| | | WBPaper00052884:emb-4(hc60)_upregulated |
| | | WBPaper00053184:sma-2(rax5)_upregulated |
| | | WBPaper00053184:sma-4(rax3)_upregulated |
| | | WBPaper00053321:embryo-to-L1_downregulated_nos-1(gv5)nos-2(RNAi)_SMARTseq |
| | | WBPaper00053321:embryo-to-L1_downregulated_WT_SMARTseq |
| | | WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_starved-L1_Truseq |
| | | WBPaper00053321:PGCs_depleted_NuGen |
| | | WBPaper00053814:15C_downregulated_PY79 |
| | | WBPaper00054758:alg-1(gk204)_upregulated |
| | | WBPaper00055060:flr-1(RNAi)_upregulated |
| | | WBPaper00055334:DLC-1_interacting |
| | | WBPaper00055354:Psora-Allantoin_downregulated |
| | | WBPaper00055354:Rapamycin-Allantoin_downregulated |
| | | WBPaper00055354:Rifampicin-Allantoin_downregulated |
| | | WBPaper00055482:Tunicamycin_downregulated |
| | | WBPaper00055969:electromagnetic-field_downregulated |
| | | WBPaper00055971:nhl-2(ok818)_25C_upregulated |
| | | WBPaper00056034:pals-22(jy3)_upregulated |
| | | WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047) |
| | | WBPaper00056090:E.faecalis_upregulated_N2 |
| | | WBPaper00056443:sek-1(km4)_upregulated |
| | | WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated |
| | | WBPaper00056471:S.aureus-4h_downregulated_N2 |
| | | WBPaper00056826:hmc_biased |
| | | WBPaper00056868:P.aeruginosa_upregulated_smallRNA |
| | | WBPaper00056900:PID-3_interacting |
| | | WBPaper00056900:TOFU-6_interacting |
| | | WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C |
| | | WBPaper00057140:meg-3(tm4259)_meg-4(ax2026)_downregulated |
| | | WBPaper00057288:Cold_downregulated_protein |
| | | WBPaper00057288:Cold_downregulated_transcript |
| | | WBPaper00058598:mex-3(eu149)_upregulated |
| | | WBPaper00058598:sin-3(tm1276)_downregulated |
| | | WBPaper00058948:PA14_downregulated |
| | | WBPaper00059328:mrps-5(RNAi)_downregulated_protein |
| | | WBPaper00059328:mrps-5(RNAi)_upregulated_mRNA |
| | | WBPaper00059356:BAZ-2_SET-6_interacting |
| | | WBPaper00059471:EGL-43_interacting |
| | | WBPaper00059605:MUT-16_interacting |
| | | WBPaper00059824:rnp-6(dh1127)_regulated_S.aureus |
| | | WBPaper00060358:B.thuringiensis_non-pathogen_regulated_N2 |
| | | WBPaper00060434:pH4.33_vs_pH6.33_downrgulated |
| | | WBPaper00060661:sensory-neuron_enriched |
| | | WBPaper00061203:let-418(n3536)_upregulated |
| | | WBPaper00061203:sin-3(tm1276)_upregulated |
| | | WBPaper00061203:spr-1(ok2144)_upregulated |
| | | WBPaper00061340:hmc_homolog |
| | | WBPaper00061340:M_cell |
| | | WBPaper00061377:MYRF-1_interacting |
| | | WBPaper00061377:PAN-1_interacting |
| | | WBPaper00061466:nath-10(icb99)_upregulated |
| | | WBPaper00061466:nath-10(icb102)_upregulated |
| | | WBPaper00061527:176662_at-Y53F4B.16 |
| | | WBPaper00061527:F49E2.5_8378-anc-1_2769 |
| | | WBPaper00061527:saeg-1_18803-mpz-2_15880 |
| | | WBPaper00061527:tub-2_4713-daf-2_5288 |
| | | WBPaper00061651:DA_enriched |
| | | WBPaper00061651:DB_enriched |
| | | WBPaper00061651:Distal_tip_cell_enriched |
| | | WBPaper00061651:DVB_enriched |
| | | WBPaper00061651:Gonadal_sheath_cell_enriched |
| | | WBPaper00061651:HSN_enriched |
| | | WBPaper00061651:I3_enriched |
| | | WBPaper00061651:M1_enriched |
| | | WBPaper00061651:M5_enriched |
| | | WBPaper00061651:MC_enriched |
| | | WBPaper00061651:PLM_enriched |
| | | WBPaper00061651:VA12_enriched |
| | | WBPaper00061651:VB01_enriched |
| | | WBPaper00061753:csr-1(tor159)_upregulated_25C |
| | | WBPaper00062159:hda-2(ok1479)_upregulated |
| | | WBPaper00062498:PPM-1.D_interacting |
| | | WBPaper00062554:MAGU-2_interacting |
| | | WBPaper00062669:extracellular-vesicle_protein |
| | | WBPaper00064055:trl-1(cas1077)_upregulated_non-starved |
| | | WBPaper00064055:trl-1(cas1077)_upregulated_starved |
| | | WBPaper00064071:NHR-49_interacting |
| | | WBPaper00064088:Day-3-adult_vs_L4_upregulated_glp-1(e2141) |
| | | WBPaper00064122:vulva_transcriptome |
| | | WBPaper00064156:lbp-3(overexpress)_upregulated |
| | | WBPaper00064201:SNA-3_interacting |
| | | WBPaper00064306:Agaro-oligosaccharides_upregulated |
| | | WBPaper00064315:mes-3(bn199)_upregulated_EGCs |
| | | WBPaper00064315:mes-4(bn73)_upregulated_EGCs |
| | | WBPaper00064315:mes-4(bn73)_upregulated_PGCs |
| | | WBPaper00064315:mrg-1(qa6200)_upregulated_PGCs |
| | | WBPaper00064624:iHg-induced_aggregome |
| | | WBPaper00064716:paraquat_downregulated |
| | | WBPaper00064769:him-17(me24)_upregulated |
| | | WBPaper00065005:sams-3(RNAi)_upregulated |
| | | WBPaper00065120:body-muscle-transcriptome |
| | | WBPaper00065373:Cisplatin_downregulated_WT |
| | | WBPaper00065373:sek-1(km4)_downregulated_cisplatin |
| | | WBPaper00065623:28 |
| | | WBPaper00065623:51 |
| | | WBPaper00065623:55 |
| | | WBPaper00065623:97 |
| | | WBPaper00065841:7_0 |
| | | WBPaper00065975:P-body_vs_oocyte_depleted |
| | | WBPaper00065975:P-body_vs_WholeAnimal_depleted |
| | | WBPaper00065993:glp-1(e2141)_upregulated |
| | | WBPaper00066038:mip-1(how5)_upregulated |
| | | WBPaper00066085:sin-3(syb2172)_upregulated |
| | | WBPaper00066146:germline-inx-14(RNAi)_upregulated_PA14 |
| | | cgc4489_group_18 |
| | | cgc4489_group_20 |
| | | cgc4489_group_24 |
| | | WBPaper00005124:testosterone_10-9M_regulated |
| | | WBPaper00025032:cluster_12 |
| | | WBPaper00025032:cluster_187 |
| | | WBPaper00025141:N2_Expressed_Genes |
| | | WBPaper00025141:unc-4::GFP_Expressed_Genes |
| | | WBPaper00026929:Resveratrol_regulated_daf-16 |
| | | WBPaper00026929:sir-2.1_overexpression_regulated |
| | | WBPaper00027111:rrf-2(ok210)_upregulated |
| | | WBPaper00027342:alpha-Synuclein(A53T)_downregulated |
| | | WBPaper00028948:cep-1(gk138)_upregulated |
| | | WBPaper00030985:Serratia_marcesens_upregulated |
| | | WBPaper00031003:hlh_1_enriched |
| | | WBPaper00031252:AIN-1_IP_enriched |
| | | WBPaper00031252:AIN-2_IP_enriched |
| | | WBPaper00031532:Larva_Pan_Neuronal_Depleted |
| | | WBPaper00031832:slr-2_regulated |
| | | WBPaper00032165:A_to_C_transit_increased |
| | | WBPaper00032165:differentially_expressed_with_age_medoid_1 |
| | | WBPaper00034661:AgNPs_downregulated |
| | | WBPaper00035873:dpy-10_regulated |
| | | WBPaper00036286:Pattern_C |
| | | WBPaper00039835:ifg-1_upregulated |
| | | WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2 |
| | | WBPaper00040821:Au-NP_regulated |
| | | WBPaper00041002:HF_3d_0.2mM_Up |
| | | WBPaper00041002:HF_3d_2.0mM_Up |
| | | WBPaper00041002:HF_11d_2.0mM_Up |
| | | WBPaper00041174:environmental |
| | | WBPaper00041174:genotypic |
| | | WBPaper00041174:genotypic_and_environmental |
| | | WBPaper00041606:CE_X.nematophila_regulated |
| | | WBPaper00041939:control_vs_EtBr-exposed_3h |
| | | WBPaper00041939:control_vs_EtBr-exposed_48h |
| | | WBPaper00041939:control_vs_UVC-EtBr-exposed_24h |
| | | WBPaper00041939:control_vs_UVC-EtBr-exposed_48h |
| | | WBPaper00041939:control_vs_UVC-EtBr-exposed_51h |
| | | WBPaper00041939:control_vs_UVC-exposed_48h |
| | | WBPaper00041939:EtBr-exposed_vs_UVC-exposed_3h |
| | | WBPaper00041939:EtBr-exposed_vs_UVC-exposed_24h |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_EtBr-exposed_48h |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_EtBr-exposed_51h |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_51h |
| | | WBPaper00041960:N2_fasting_upregulated_anytime |
| | | WBPaper00042178:hlh-29(tm284)_upregulated |
| | | WBPaper00042258:DA1877_upregulated_GravidAdult |
| | | WBPaper00042331:a-SWCNTs_downregulated |
| | | WBPaper00045263:0.1mM-paraquat_upregulated |
| | | WBPaper00045263:nuo-6(qm200)_upregulated |
| | | WBPaper00045865:biofilm_downregulated_B |
| | | WBPaper00046548:dafachronic-acid_downregulated |
| | | WBPaper00047070:N2_starvation_upregulated |
| | | WBPaper00047070:N2_UV_upregulated |
| | | WBPaper00047070:xpa-1_UV_downregulated |
| | | WBPaper00048624:hlh-25(ok1710)_downregulated |
| | | WBPaper00048624:hlh-25(ok1710)_upregulated |
| | | WBPaper00048989:eat-2(ad465)_rapamycin_downregulated |
| | | WBPaper00048989:N2_allantoin_downregulated |
| | | WBPaper00048989:N2_rapamycin_upregulated |
| | | WBPaper00050650:mBmkTX_downregulated |
| | | WBPaper00053688:E.faecalis_upregulated |
| | | WBPaper00057098:SiO2-nanoparticles_upregulated |
| | | [cgc5376]:let-60(G12V)-regulated_genes |
| | | [cgc6390]:Cluster_B |
| | Interaction (51) |
| Map_info | Map | I | Position | -1.5 | Error | 0.011025 |
| | Positive | Positive_clone | ZK973 | Inferred_automatically | From sequence, transcript, pseudogene data |
| | Mapping_data | 2_point | 642 |
| | | Multi_point | 572 |
| | | | 573 |
| | | | 574 |
| | | | 575 |
| | | | 5329 |
| | | Pos_neg_data | 6698 |
| | | | 6699 |
| Reference (46) |
| Remark | Starr DA, Han M, modified prediction. [021111 ck1] |
| Method | Gene |
