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WormBase Tree Display for Gene: WBGene00000096

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Name Class

WBGene00000096SMapS_parentSequenceC41G7
IdentityVersion1
NameCGC_nameahr-1Person_evidenceWBPerson698
Sequence_nameC41G7.5
Molecular_nameC41G7.5a
C41G7.5a.1
CE20561
C41G7.5b
CE38293
C41G7.5b.1
Other_nameCELE_C41G7.5Accession_evidenceNDBBX284601
Public_nameahr-1
DB_infoDatabaseWormQTLgeneWBGene00000096
WormFluxgeneWBGene00000096
NDBlocus_tagCELE_C41G7.5
PanthergeneCAEEL|WormBase=WBGene00000096|UniProtKB=O44712
familyPTHR10649
NCBIgene172788
RefSeqproteinNM_001025866.5
NM_001025865.4
SwissProtUniProtAccO44712
TREEFAMTREEFAM_IDTF352074
UniProt_GCRPUniProtAccO44712
OMIMgene600253
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:20WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classahr
Allele (122)
StrainWBStrain00040825
WBStrain00040826
WBStrain00040823
WBStrain00005374
RNASeq_FPKM (74)
GO_annotation (27)
Ortholog (45)
Structured_descriptionConcise_descriptionahr-1 encodes an aryl hydrocarbon receptor (ligand-activated basic helix-loop-helix transcription factor) ortholog that biochemically resembles its vertebrate relatives (OMIM:600253) which mediate the carcinogenic and teratogenic effects of environmental toxins; AHR-1 activity is required for specification of RMEL and RMER GABAergic neuron cell fate and negative regulation of spontaneous movement; AHR-1 binds HSP90 tightly, and forms a dimer with AHA-1 that binds DNA fragments containing the mammalian xenobiotic response element; AHR-1 is expressed in neurons.Paper_evidenceWBPaper00003028
WBPaper00045799
WBPaper00006431
Curator_confirmedWBPerson1843
WBPerson567
Date_last_updated09 Oct 2014 00:00:00
Automated_descriptionEnables DNA binding activity and RNA polymerase II-specific DNA-binding transcription factor binding activity. Involved in negative regulation of locomotion and response to xenobiotic stimulus. Predicted to be located in nucleus. Predicted to be part of nuclear aryl hydrocarbon receptor complex. Expressed in ALML; ALMR; RMEL; RMER; and neurons. Human ortholog(s) of this gene implicated in pancreatic cancer and retinitis pigmentosa 85. Is an ortholog of human AHR (aryl hydrocarbon receptor).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoPotential_modelDOID:0112142Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:348)
DOID:1793Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:348)
Molecular_infoCorresponding_CDSC41G7.5a
C41G7.5b
Corresponding_transcriptC41G7.5a.1
C41G7.5b.1
Other_sequenceAF039570
CSC00770_1
FC549627.1
JI173487.1
FD514200.1
FC542139.1
BMC06690_1
JI228539.1
Associated_featureWBsf643595
WBsf656757
WBsf978412
WBsf984722
WBsf984723
WBsf984724
WBsf984725
WBsf1010390
WBsf218299
Transcription_factorWBTranscriptionFactor000144
WBTranscriptionFactor000463
Experimental_infoRNAi_resultWBRNAi00070616Inferred_automaticallyRNAi_primary
WBRNAi00027737Inferred_automaticallyRNAi_primary
WBRNAi00003135Inferred_automaticallyRNAi_primary
WBRNAi00082585Inferred_automaticallyRNAi_primary
WBRNAi00042319Inferred_automaticallyRNAi_primary
WBRNAi00075872Inferred_automaticallyRNAi_primary
WBRNAi00003134Inferred_automaticallyRNAi_primary
WBRNAi00115757Inferred_automaticallyRNAi_primary
WBRNAi00070617Inferred_automaticallyRNAi_primary
Expr_patternExpr2855
Expr2937
Expr7905
Expr13952
Expr1028426
Expr1030046
Expr1146308
Expr2009271
Expr2027508
Drives_constructWBCnstr00000621
WBCnstr00000622
WBCnstr00010989
WBCnstr00012982
WBCnstr00016015
WBCnstr00037737
Construct_productWBCnstr00005433
WBCnstr00018908
WBCnstr00021789
WBCnstr00037737
Regulate_expr_clusterWBPaper00035560:ahr-1_downregulated
WBPaper00035560:ahr-1_upregulated
WBPaper00044753:ahr-1_downregulated
WBPaper00044753:ahr-1_upregulated
WBPaper00060797:ahr-1(ju145)_downregulated
WBPaper00060797:ahr-1(ju145)_upregulated
WBPaper00064073:ahr-1(ju145)_downregulated
WBPaper00064073:ahr-1(ju145)_upregulated
Microarray_results (23)
Expression_clusterWBPaper00033065:cyc-1(RNAi)_downregulated
WBPaper00036375:enriched_in_PVD_OLL
WBPaper00037950:A-class-motor-neurons_L2-larva_expressed
WBPaper00037950:all-neurons_L1-larva_expressed
WBPaper00037950:all-neurons_L2-larva_expressed
WBPaper00037950:all-neurons_larva_enriched
WBPaper00037950:AVA-neuron_L1-larva_expressed
WBPaper00037950:dopaminergic-neurons_L1-larva_expressed
WBPaper00037950:GABAergic-motor-neurons_embryo_enriched
WBPaper00037950:GABAergic-motor-neurons_embryo_SelectivelyEnriched
WBPaper00037950:GABAergic-motor-neurons_L1-larva_expressed
WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed
WBPaper00037950:hypodermis_L3-L4-larva_expressed
WBPaper00037950:intestine_L1-larva_expressed
WBPaper00038438:D.coniospora_12hr_downregulated_RNAseq
WBPaper00038438:P.lumniescens_24hr_upregulated_RNAseq
WBPaper00038438:P.lumniescens_24hr_upregulated_TilingArray
WBPaper00038438:S.marcescens_24hr_upregulated_RNAseq
WBPaper00045390:ubc-9(RNAi)_downregulated
WBPaper00045521:Spermatogenic
WBPaper00046121:ecdoderm_unique
WBPaper00048690:gonad-hermaphrodite-biased
WBPaper00048923:Aging_regulated
WBPaper00048988:neuron_enriched
WBPaper00048988:neuron_expressed
WBPaper00050163:chd-3(eh4);let-418(RNAi)_upregulated_24-cell-embryo
WBPaper00050163:let-418(RNAi)_upregulated_24-cell-embryo
WBPaper00050488:adult_vs_dauer_regulated_N2_20C
WBPaper00050726:OsmoticStress_regulated_Food
WBPaper00050859:upregulated_glh-1(gk100)_vs_control_day1-adult
WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult
WBPaper00050990:NMDA-neuron_enriched
WBPaper00050990:NMDA-neuron_expressed
WBPaper00053302:stavudine_24h_regulated
WBPaper00053302:zidovudine_72h_regulated
WBPaper00053308:SMG-2_associated_NMD(-)_unaltered_ClassII
WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_starved-L1_Truseq
WBPaper00053771:up_at_dpy-7(e88)
WBPaper00053798:nhr-49(nr2041)_tBOOH_upregulated
WBPaper00055013:hmg-3(bar24)_upregulated
WBPaper00055103:thoc-5(wy822)_upregulated
WBPaper00055354:eat-2(ad1116)_upregulated
WBPaper00055354:Metformin_upregulated
WBPaper00055354:Psora-Allantoin_upregulated
WBPaper00055354:Rapamycin-Metformin_upregulated
WBPaper00055354:Rapamycin-Psora-Allantoin_upregulated
WBPaper00055354:Rapamycin-Rifampicin-Allantoin_upregulated
WBPaper00055354:Rapamycin-Rifampicin-Psora_upregulated
WBPaper00055354:Rapamycin-Rifampicin_upregulated
WBPaper00055354:Rifampicin-Allantoin_upregulated
WBPaper00055354:Rifampicin-Psora_upregulated
WBPaper00055354:Rifampicin_upregulated
WBPaper00056161:male_enriched_siRNA
WBPaper00056169:rrf-3(pk1426)_upregulated_embryo
WBPaper00056826:hmc_biased
WBPaper00056855:his-72(uge40)_upregulated
WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C
WBPaper00058598:sin-3(tm1276)_downregulated
WBPaper00058948:PA14_downregulated
WBPaper00059664:srbc-48(ac23)_upregulated
WBPaper00059754:E.faecalis_OG1RF_upregulated
WBPaper00060014:set-2(tm1630)_downregulated
WBPaper00060014:set-2(zr2012)_downregulated
WBPaper00060661:sensory-neuron_enriched
WBPaper00060811:L1_vs_adult_downregulated_neural
WBPaper00061081:E.faecalis_upregulated_N2
WBPaper00061203:sin-3(tm1276)_upregulated
WBPaper00061203:spr-1(ok2144)_upregulated
WBPaper00061340:ALM_BDU
WBPaper00061340:ALN
WBPaper00061340:G2_and_W_blasts
WBPaper00061340:Neuroblast_ALM_BDU
WBPaper00061340:Neuroblast_URX_CEPDx
WBPaper00061340:Parent_of_MI_pm1DR
WBPaper00061340:PLM
WBPaper00061340:PLM_ALN_grandparent
WBPaper00061340:PLM_ALN_great_grandparent
WBPaper00061340:RME
WBPaper00061340:URX
WBPaper00061341:28C_24h_upregulated
WBPaper00061341:28C_48h_upregulated
WBPaper00061479:hda-1(ne4752)_upregulated
WBPaper00061479:mep-1(ne4629)_upregulated
WBPaper00061527:F58E6.13_17427-ifa-3
WBPaper00061651:ALN_enriched
WBPaper00061651:PLN_enriched
WBPaper00061651:SDQ_enriched
WBPaper00062103:neuron_enriched
WBPaper00062159:hda-2(ok1479)_upregulated
WBPaper00062325:muscle_depleted_coding-RNA
WBPaper00064005:starvation_upregulated_N2_mRNA
WBPaper00064088:Day-1-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
WBPaper00064088:Day-1-adult_vs_L4_downregulated_glp-1(e2141)
WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20)
WBPaper00064088:Day-3-adult_vs_L4_downregulated_glp-1(e2141)
WBPaper00064509:static-magnetic-field_downregulated
WBPaper00064721:fasn-1(g14)_downregulated_starved
WBPaper00065029:cadmium_upregulated
WBPaper00065841:20_1
WBPaper00065841:28_0
WBPaper00065841:39_0
WBPaper00065841:39_1
WBPaper00065841:39_2
WBPaper00065841:39_3
WBPaper00065841:51_0
WBPaper00065841:51_1
WBPaper00065841:59_0
WBPaper00065841:80_0
WBPaper00065841:118_0
cgc4489_group_11
WBPaper00025099:MA_specific
WBPaper00030839:Larval_Pan_Neuronal
WBPaper00031252:AIN-1_IP_enriched
WBPaper00031252:AIN-2_IP_enriched
WBPaper00031532:Larva_Pan_Neuronal_Enriched
WBPaper00040858:eQTL_regulated_developing
WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h
WBPaper00045401:N.parisii_34h_downregulated_N2
[cgc6390]:Cluster_D
[cgc6390]:spermatogenesis-enriched
Interaction (95)
Anatomy_functionWBbtf0279
WBbtf0280
Map_infoMapIPosition3.79382Error0.001948
PositivePositive_cloneC41G7Inferred_automaticallyFrom sequence, transcript, pseudogene data
Mapping_dataMulti_point4148
5375
Pseudo_map_position
Reference (45)
RemarkMap position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene