WormBase Tree Display for Gene: WBGene00000090
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| WBGene00000090 | SMap | S_parent | Sequence | CHROMOSOME_II | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | age-1 | Person_evidence | WBPerson295 | |||||
| Sequence_name | B0334.8 | ||||||||
| Molecular_name | B0334.8a | ||||||||
| B0334.8a.1 | |||||||||
| CE43431 | |||||||||
| B0334.8b | |||||||||
| CE02940 | |||||||||
| B0334.8b.1 | |||||||||
| Other_name | daf-23 | ||||||||
| CELE_B0334.8 | Accession_evidence | NDB | BX284602 | ||||||
| Public_name | age-1 | ||||||||
| DB_info | Database (13) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:20 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | age | ||||||||
| Allele (173) | |||||||||
| Possibly_affected_by | WBVar02158447 | ||||||||
| Legacy_information | [Morris JZ, Tissenbaum HA ] hx546 fails to supply maternal daf-23 activity, has Age phenotype, mg44 is probable null, has dauer-constitutive phenotype. | ||||||||
| [C.elegansII] m333mat : nonconditional, constitutive formationof dauers and dauer-like larvae; maternally rescued adults are Egl; increased lifespan; probably allelic with age-1. ES3(L3).OA>4: mg44, etc. [Gottlieb and Ruvkun 1994; Larsen et al. 1995; DR; GR] | |||||||||
| Complementation_data | [Morris JZ, Tissenbaum HA ] age-1(hx546) fails to complement daf-23(mg44) | ||||||||
| Strain (20) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (44) | |||||||||
| Contained_in_operon | CEOP2552 | ||||||||
| Ortholog (51) | |||||||||
| Paralog | WBGene00009552 | Caenorhabditis elegans | From_analysis | TreeFam | |||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00018076 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00006932 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00013557 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | age-1 encodes the C. elegans ortholog of the phosphoinositide 3-kinase (PI3K) p110 catalytic subunit; AGE-1, supplied maternally and embryonically, is a central component of the C. elegans insulin-like signaling pathway, lying downstream of the DAF-2/insulin receptor and upstream of both the PDK-1 and AKT-1/AKT-2 kinases and the DAF-16 forkhead type transcription factor, whose negative regulation is the key output of the insulin signaling pathway; in accordance with its role in insulin signaling, AGE-1 activity is required for regulation of metabolism, life span, dauer formation, stress resistance, salt chemotaxis learning, fertility, and embryonic development; although the age-1 expression pattern has not yet been reported, ectopic expression studies indicate that pan-neuronal age-1 expression is sufficient to rescue life-span defects, while neuronal, intestinal, or muscle expression can partially rescue dauer formation, and neuronal or muscle expression can rescue metabolic defects. | Paper_evidence | WBPaper00002514 | |||||
| WBPaper00003008 | |||||||||
| WBPaper00003568 | |||||||||
| WBPaper00004356 | |||||||||
| WBPaper00004599 | |||||||||
| WBPaper00005614 | |||||||||
| WBPaper00028460 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 13 Dec 2006 00:00:00 | ||||||||
| Automated_description | Predicted to enable 1-phosphatidylinositol-3-kinase activity and 1-phosphatidylinositol-4-phosphate 3-kinase activity. Involved in several processes, including dauer entry; determination of adult lifespan; and regulation of synaptic assembly at neuromuscular junction. Located in cytoplasm and non-motile cilium. Part of phosphatidylinositol 3-kinase complex. Expressed in amphid neurons; anchor cell; hypodermis; and pharyngeal-intestinal valve. Human ortholog(s) of this gene implicated in several diseases, including breast cancer (multiple); gastrointestinal system cancer (multiple); and reproductive organ cancer (multiple). Is an ortholog of human PIK3CB (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta); PIK3CD (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta); and PIK3CG (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model (27) | ||||||||
| Molecular_info | Corresponding_CDS | B0334.8a | |||||||
| B0334.8b | |||||||||
| Corresponding_CDS_history | B0334.8:wp198 | ||||||||
| Corresponding_transcript | B0334.8a.1 | ||||||||
| B0334.8b.1 | |||||||||
| Other_sequence (26) | |||||||||
| Associated_feature | WBsf989790 | ||||||||
| Experimental_info (10) | |||||||||
| Map_info | Map | II | Position | 3.612 | Error | 0.011314 | |||
| Well_ordered | |||||||||
| Positive | Positive_clone | B0334 | Person_evidence | WBPerson657 | |||||
| Author_evidence | Morris JZ | ||||||||
| Inferred_automatically | From sequence, transcript, pseudogene data | ||||||||
| Mapping_data | 2_point | 2595 | |||||||
| Multi_point | 1067 | ||||||||
| 1070 | |||||||||
| 1071 | |||||||||
| 1052 | |||||||||
| 1053 | |||||||||
| 1468 | |||||||||
| 1556 | |||||||||
| 2219 | |||||||||
| 3442 | |||||||||
| Pos_neg_data | 3224 | ||||||||
| 4212 | |||||||||
| 4216 | |||||||||
| 4217 | |||||||||
| 4218 | |||||||||
| 8964 | |||||||||
| 8965 | |||||||||
| 8966 | |||||||||
| Reference (631) | |||||||||
| Picture | WBPicture0000013078 | ||||||||
| Remark | Data extracted from Morris, Tissenbaum & Ruvkun 1996 | ||||||||
| Method | Gene |
