WormBase Tree Display for Gene: WBGene00000085
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| WBGene00000085 | SMap | S_parent | Sequence | CHROMOSOME_X | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | aex-2 | Person_evidence | WBPerson655 | |||||
| Sequence_name | T14B1.2 | ||||||||
| Molecular_name | T14B1.2 | ||||||||
| T14B1.2.1 | |||||||||
| CE31607 | |||||||||
| Other_name | CELE_T14B1.2 | Accession_evidence | NDB | BX284606 | |||||
| Public_name | aex-2 | ||||||||
| DB_info | Database | WormQTL | gene | WBGene00000085 | |||||
| WormFlux | gene | WBGene00000085 | |||||||
| NDB | locus_tag | CELE_T14B1.2 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00000085|UniProtKB=G5ECD9 | |||||||
| family | PTHR21643 | ||||||||
| NCBI | gene | 188491 | |||||||
| RefSeq | protein | NM_077225.8 | |||||||
| SwissProt | UniProtAcc | G5ECD9 | |||||||
| TREEFAM | TREEFAM_ID | TF316587 | |||||||
| UniProt_GCRP | UniProtAcc | G5ECD9 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:20 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| 2 | 20 Oct 2008 11:06:18 | WBPerson2970 | Event | Acquires_merge | WBGene00011764 | ||||
| Name_change | Sequence_name | T14B1.2 | |||||||
| Acquires_merge | WBGene00011764 | ||||||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | aex | ||||||||
| Allele (36) | |||||||||
| Legacy_information | [Jim Thomas] Defecation defective, severely constipated, expulsion muscle contraction (Exp) nearly always absent, anterior body contraction (aBoc) either absent or mistimed, adult male unaffected and mates well. | ||||||||
| See also sa3, sa21 | |||||||||
| [C.elegansII] sa3 : defecation defective, severely constipated, expulsion muscle contraction (Exp) nearly always absent, anterior body contraction (aBoc) either absent or mistimed, adult male unaffected and mates well. OA1: sa21 (similar) [Thomas 1990; JT] | |||||||||
| Strain | WBStrain00022768 | ||||||||
| WBStrain00031024 | |||||||||
| WBStrain00055133 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (24) | |||||||||
| Ortholog (27) | |||||||||
| Paralog | WBGene00016090 | Caenorhabditis elegans | From_analysis | TreeFam | |||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00016089 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00016748 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | aex-2 encodes a G-protein-coupled receptor; aex-2 functions in the nervous system to activate a G(s) alpha (gsa-1) signaling pathway that regulates defecation in the hermaphrodite digestive tract; in regulating the defecation cycles, AEX-2 likely serves as the receptor for the NLP-40 neuropeptide secreted by the intestine; an AEX-2::GFP reporter fusion is expressed in the nerve ring, ventral nerve cord, the head mesodermal cell and enteric muscles; tissue-specific expression studies suggest that AEX-2 acts in GABAergic neurons, such as AVL and DVB, to control the expulsion, and possibly anterior body contraction, steps of defecation. | Paper_evidence | WBPaper00002688 | |||||
| WBPaper00032261 | |||||||||
| WBPaper00042242 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 18 Aug 2014 00:00:00 | ||||||||
| Automated_description | Predicted to enable neuropeptide receptor activity. Involved in lipid transport involved in lipid storage; neuropeptide signaling pathway; and positive regulation of transport. Predicted to be located in cilium and plasma membrane. Expressed in alimentary muscle; head mesodermal cell; intestine; and nervous system. | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | T14B1.2 | |||||||
| Corresponding_CDS_history | T14B1.2:wp83 | ||||||||
| Corresponding_transcript | T14B1.2.1 | ||||||||
| Other_sequence | PPC13869_1 | ||||||||
| Associated_feature | WBsf1006499 | ||||||||
| WBsf1006500 | |||||||||
| WBsf1006501 | |||||||||
| WBsf1023608 | |||||||||
| WBsf237781 | |||||||||
| Experimental_info | RNAi_result (13) | ||||||||
| Expr_pattern | Expr43 | ||||||||
| Expr8378 | |||||||||
| Expr16345 | |||||||||
| Expr1022526 | |||||||||
| Expr1156892 | |||||||||
| Expr2009247 | |||||||||
| Expr2027484 | |||||||||
| Drives_construct | WBCnstr00005429 | ||||||||
| WBCnstr00005430 | |||||||||
| WBCnstr00037743 | |||||||||
| WBCnstr00042965 | |||||||||
| Construct_product | WBCnstr00005429 | ||||||||
| WBCnstr00005430 | |||||||||
| WBCnstr00037743 | |||||||||
| Microarray_results (18) | |||||||||
| Expression_cluster (81) | |||||||||
| Interaction | WBInteraction000519694 | ||||||||
| WBInteraction000519699 | |||||||||
| WBInteraction000519706 | |||||||||
| WBInteraction000521099 | |||||||||
| WBInteraction000548178 | |||||||||
| WBInteraction000555199 | |||||||||
| WBInteraction000556797 | |||||||||
| WBProcess | WBbiopr:00000010 | ||||||||
| Map_info | Map | X | Position | 1.4249 | Error | 0.002784 | |||
| Positive | Positive_clone | T14B1 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | 2_point | 6026 | |||||||
| 6028 | |||||||||
| 7018 | |||||||||
| 7019 | |||||||||
| 7021 | |||||||||
| Multi_point (17) | |||||||||
| Pos_neg_data | 6725 | ||||||||
| Reference (33) | |||||||||
| Method | Gene |
