WormBase Tree Display for Gene: WBGene00000072
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| WBGene00000072 | SMap | S_parent | Sequence | F39C12 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | add-1 | |||||||
| Sequence_name | F39C12.2 | ||||||||
| Molecular_name (15) | |||||||||
| Other_name | CELE_F39C12.2 | Accession_evidence | NDB | BX284606 | |||||
| Public_name | add-1 | ||||||||
| DB_info | Database (12) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:20 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | add | ||||||||
| Allele (110) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (19) | |||||||||
| Ortholog (42) | |||||||||
| Paralog | WBGene00000073 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | add-1 encodes an ortholog of the cytoskeletal protein alpha-adducin (ADD1, OMIM:102680, mutations are associated with susceptibility to salt-sensitive essential hypertension); by homology, ADD-1 is predicted to be a cell membrane-associated protein that mediates localized changes in the cytoskeleton in response to activation of signal transduction cascades; in C. elegans, ADD-1 activity is required for short- and long-term memory, specifically for regulation of actin cytoskeleton organization and regulation of GLR-1 ionotropic glutamate receptor dynamics in the AVA command interneuron; RNAi experiments have also shown that add-1 activity is required for effective transgene-induced co-suppression in the germline; add-1 is expressed in the nervous system, intestinal and rectal epithelia, seam cells and coelomocytes; in the ventral nerve cord, ADD-1 co-localizes to the post-synaptic density with GLR-1. | Paper_evidence | WBPaper00004424 | |||||
| WBPaper00005654 | |||||||||
| WBPaper00025139 | |||||||||
| WBPaper00040733 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 17 Feb 2012 00:00:00 | ||||||||
| Automated_description | Predicted to enable actin filament binding activity. Involved in actin filament bundle organization; memory; and receptor localization to synapse. Located in postsynaptic density. Expressed in GLR; coelomocyte; and neurons. Human ortholog(s) of this gene implicated in several diseases, including IgA glomerulonephritis; artery disease (multiple); and familial combined hyperlipidemia. Is an ortholog of human ADD1 (adducin 1); ADD2 (adducin 2); and ADD3 (adducin 3). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:2986 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:243,HGNC:244) | ||||
| DOID:13809 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:243) | ||||||
| DOID:5844 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:243) | ||||||
| DOID:10591 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:243) | ||||||
| DOID:10763 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:243,HGNC:244) | ||||||
| DOID:11044 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:243) | ||||||
| DOID:10825 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:243) | ||||||
| DOID:0081361 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:245) | ||||||
| DOID:1936 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:243) | ||||||
| Molecular_info | Corresponding_CDS | F39C12.2a | |||||||
| F39C12.2b | |||||||||
| F39C12.2c | |||||||||
| F39C12.2d | |||||||||
| F39C12.2e | |||||||||
| Corresponding_transcript | F39C12.2a.1 | ||||||||
| F39C12.2b.1 | |||||||||
| F39C12.2c.1 | |||||||||
| F39C12.2d.1 | |||||||||
| F39C12.2e.1 | |||||||||
| Other_sequence (26) | |||||||||
| Associated_feature | WBsf670468 | ||||||||
| WBsf670469 | |||||||||
| WBsf1005092 | |||||||||
| WBsf237324 | |||||||||
| WBsf237325 | |||||||||
| WBsf237326 | |||||||||
| WBsf237327 | |||||||||
| WBsf237328 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00046766 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00069444 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00014595 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00027903 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Chronogram1729 | ||||||||
| Expr6000 | |||||||||
| Expr9950 | |||||||||
| Expr1010334 | |||||||||
| Expr1150640 | |||||||||
| Expr2009233 | |||||||||
| Expr2027470 | |||||||||
| Drives_construct | WBCnstr00003377 | ||||||||
| WBCnstr00014964 | |||||||||
| WBCnstr00037752 | |||||||||
| Construct_product | WBCnstr00014964 | ||||||||
| WBCnstr00037752 | |||||||||
| Microarray_results (48) | |||||||||
| Expression_cluster (172) | |||||||||
| Interaction (28) | |||||||||
| Map_info | Map | X | Position | -6.22351 | Error | 0.002328 | |||
| Positive | Positive_clone | F39C12 | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Pseudo_map_position | |||||||||
| Reference | WBPaper00010897 | ||||||||
| WBPaper00038491 | |||||||||
| WBPaper00039309 | |||||||||
| WBPaper00040733 | |||||||||
| WBPaper00042982 | |||||||||
| WBPaper00045009 | |||||||||
| WBPaper00055090 | |||||||||
| Remark | Gene created based on email from [Blasiar D], [krb 020617] | ||||||||
| Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
| Method | Gene |
