WormBase Tree Display for Gene: WBGene00000072
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WBGene00000072 | SMap | S_parent | Sequence | F39C12 | |||||
---|---|---|---|---|---|---|---|---|---|
Identity | Version | 1 | |||||||
Name | CGC_name | add-1 | |||||||
Sequence_name | F39C12.2 | ||||||||
Molecular_name (15) | |||||||||
Other_name | CELE_F39C12.2 | Accession_evidence | NDB | BX284606 | |||||
Public_name | add-1 | ||||||||
DB_info | Database (12) | ||||||||
Species | Caenorhabditis elegans | ||||||||
History | Version_change | 1 | 07 Apr 2004 11:29:20 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
Status | Live | ||||||||
Gene_info | Biotype | SO:0001217 | |||||||
Gene_class | add | ||||||||
Allele (110) | |||||||||
RNASeq_FPKM (74) | |||||||||
GO_annotation (19) | |||||||||
Ortholog (42) | |||||||||
Paralog | WBGene00000073 | Caenorhabditis elegans | From_analysis (2) | ||||||
Structured_description | Concise_description | add-1 encodes an ortholog of the cytoskeletal protein alpha-adducin (ADD1, OMIM:102680, mutations are associated with susceptibility to salt-sensitive essential hypertension); by homology, ADD-1 is predicted to be a cell membrane-associated protein that mediates localized changes in the cytoskeleton in response to activation of signal transduction cascades; in C. elegans, ADD-1 activity is required for short- and long-term memory, specifically for regulation of actin cytoskeleton organization and regulation of GLR-1 ionotropic glutamate receptor dynamics in the AVA command interneuron; RNAi experiments have also shown that add-1 activity is required for effective transgene-induced co-suppression in the germline; add-1 is expressed in the nervous system, intestinal and rectal epithelia, seam cells and coelomocytes; in the ventral nerve cord, ADD-1 co-localizes to the post-synaptic density with GLR-1. | Paper_evidence | WBPaper00004424 | |||||
WBPaper00005654 | |||||||||
WBPaper00025139 | |||||||||
WBPaper00040733 | |||||||||
Curator_confirmed | WBPerson1843 | ||||||||
Date_last_updated | 17 Feb 2012 00:00:00 | ||||||||
Automated_description | Predicted to enable actin filament binding activity. Involved in actin filament bundle organization; memory; and receptor localization to synapse. Located in postsynaptic density. Expressed in GLR; coelomocyte; and neurons. Human ortholog(s) of this gene implicated in several diseases, including IgA glomerulonephritis; artery disease (multiple); and familial combined hyperlipidemia. Is an ortholog of human ADD1 (adducin 1); ADD2 (adducin 2); and ADD3 (adducin 3). | Paper_evidence | WBPaper00065943 | ||||||
Curator_confirmed | WBPerson324 | ||||||||
WBPerson37462 | |||||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
Disease_info | Potential_model | DOID:2986 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:243,HGNC:244) | ||||
DOID:13809 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:243) | ||||||
DOID:5844 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:243) | ||||||
DOID:10591 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:243) | ||||||
DOID:10763 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:243,HGNC:244) | ||||||
DOID:11044 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:243) | ||||||
DOID:10825 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:243) | ||||||
DOID:0081361 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:245) | ||||||
DOID:1936 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:243) | ||||||
Molecular_info | Corresponding_CDS | F39C12.2a | |||||||
F39C12.2b | |||||||||
F39C12.2c | |||||||||
F39C12.2d | |||||||||
F39C12.2e | |||||||||
Corresponding_transcript | F39C12.2a.1 | ||||||||
F39C12.2b.1 | |||||||||
F39C12.2c.1 | |||||||||
F39C12.2d.1 | |||||||||
F39C12.2e.1 | |||||||||
Other_sequence (26) | |||||||||
Associated_feature | WBsf670468 | ||||||||
WBsf670469 | |||||||||
WBsf1005092 | |||||||||
WBsf237324 | |||||||||
WBsf237325 | |||||||||
WBsf237326 | |||||||||
WBsf237327 | |||||||||
WBsf237328 | |||||||||
Experimental_info | RNAi_result | WBRNAi00046766 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00069444 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00014595 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00027903 | Inferred_automatically | RNAi_primary | |||||||
Expr_pattern | Chronogram1729 | ||||||||
Expr6000 | |||||||||
Expr9950 | |||||||||
Expr1010334 | |||||||||
Expr1150640 | |||||||||
Expr2009233 | |||||||||
Expr2027470 | |||||||||
Drives_construct | WBCnstr00003377 | ||||||||
WBCnstr00014964 | |||||||||
WBCnstr00037752 | |||||||||
Construct_product | WBCnstr00014964 | ||||||||
WBCnstr00037752 | |||||||||
Microarray_results (48) | |||||||||
Expression_cluster (172) | |||||||||
Interaction (28) | |||||||||
Map_info | Map | X | Position | -6.22351 | Error | 0.002328 | |||
Positive | Positive_clone | F39C12 | Inferred_automatically | From CDS info | |||||
From sequence, transcript, pseudogene data | |||||||||
Pseudo_map_position | |||||||||
Reference | WBPaper00010897 | ||||||||
WBPaper00038491 | |||||||||
WBPaper00039309 | |||||||||
WBPaper00040733 | |||||||||
WBPaper00042982 | |||||||||
WBPaper00045009 | |||||||||
WBPaper00055090 | |||||||||
Remark | Gene created based on email from [Blasiar D], [krb 020617] | ||||||||
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
Method | Gene |