WormBase Tree Display for Gene: WBGene00000072
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WBGene00000072 | SMap | S_parent | Sequence | F39C12 | |||
---|---|---|---|---|---|---|---|
Identity (6) | |||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | add | ||||||
Allele (110) | |||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (19) | |||||||
Ortholog (42) | |||||||
Paralog | WBGene00000073 | Caenorhabditis elegans | From_analysis | Panther | |||
WormBase-Compara | |||||||
Structured_description | Concise_description | add-1 encodes an ortholog of the cytoskeletal protein alpha-adducin (ADD1, OMIM:102680, mutations are associated with susceptibility to salt-sensitive essential hypertension); by homology, ADD-1 is predicted to be a cell membrane-associated protein that mediates localized changes in the cytoskeleton in response to activation of signal transduction cascades; in C. elegans, ADD-1 activity is required for short- and long-term memory, specifically for regulation of actin cytoskeleton organization and regulation of GLR-1 ionotropic glutamate receptor dynamics in the AVA command interneuron; RNAi experiments have also shown that add-1 activity is required for effective transgene-induced co-suppression in the germline; add-1 is expressed in the nervous system, intestinal and rectal epithelia, seam cells and coelomocytes; in the ventral nerve cord, ADD-1 co-localizes to the post-synaptic density with GLR-1. | Paper_evidence | WBPaper00004424 | |||
WBPaper00005654 | |||||||
WBPaper00025139 | |||||||
WBPaper00040733 | |||||||
Curator_confirmed | WBPerson1843 | ||||||
Date_last_updated | 17 Feb 2012 00:00:00 | ||||||
Automated_description | Predicted to enable actin filament binding activity. Involved in actin filament bundle organization; memory; and receptor localization to synapse. Located in postsynaptic density. Expressed in GLR; coelomocyte; and neurons. Human ortholog(s) of this gene implicated in several diseases, including IgA glomerulonephritis; artery disease (multiple); and familial combined hyperlipidemia. Is an ortholog of human ADD1 (adducin 1); ADD2 (adducin 2); and ADD3 (adducin 3). | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Disease_info | Potential_model | DOID:2986 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:243,HGNC:244) | ||
DOID:13809 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:243) | ||||
DOID:5844 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:243) | ||||
DOID:10591 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:243) | ||||
DOID:10763 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:243,HGNC:244) | ||||
DOID:11044 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:243) | ||||
DOID:10825 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:243) | ||||
DOID:0081361 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:245) | ||||
DOID:1936 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:243) | ||||
Molecular_info | Corresponding_CDS | F39C12.2a | |||||
F39C12.2b | |||||||
F39C12.2c | |||||||
F39C12.2d | |||||||
F39C12.2e | |||||||
Corresponding_transcript | F39C12.2a.1 | ||||||
F39C12.2b.1 | |||||||
F39C12.2c.1 | |||||||
F39C12.2d.1 | |||||||
F39C12.2e.1 | |||||||
Other_sequence (26) | |||||||
Associated_feature | WBsf670468 | ||||||
WBsf670469 | |||||||
WBsf1005092 | |||||||
WBsf237324 | |||||||
WBsf237325 | |||||||
WBsf237326 | |||||||
WBsf237327 | |||||||
WBsf237328 | |||||||
Experimental_info | RNAi_result | WBRNAi00046766 | Inferred_automatically | RNAi_primary | |||
WBRNAi00069444 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00014595 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00027903 | Inferred_automatically | RNAi_primary | |||||
Expr_pattern | Chronogram1729 | ||||||
Expr6000 | |||||||
Expr9950 | |||||||
Expr1010334 | |||||||
Expr1150640 | |||||||
Expr2009233 | |||||||
Expr2027470 | |||||||
Drives_construct | WBCnstr00003377 | ||||||
WBCnstr00014964 | |||||||
WBCnstr00037752 | |||||||
Construct_product | WBCnstr00014964 | ||||||
WBCnstr00037752 | |||||||
Microarray_results (48) | |||||||
Expression_cluster (172) | |||||||
Interaction (28) | |||||||
Map_info | Map | X | Position | -6.22351 | Error | 0.002328 | |
Positive | Positive_clone | F39C12 | Inferred_automatically | From CDS info | |||
From sequence, transcript, pseudogene data | |||||||
Pseudo_map_position | |||||||
Reference | WBPaper00010897 | ||||||
WBPaper00038491 | |||||||
WBPaper00039309 | |||||||
WBPaper00040733 | |||||||
WBPaper00042982 | |||||||
WBPaper00045009 | |||||||
WBPaper00055090 | |||||||
Remark | Gene created based on email from [Blasiar D], [krb 020617] | ||||||
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||
Method | Gene |