WormBase Tree Display for Gene: WBGene00000002
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| WBGene00000002 | Evidence | Author_evidence | Veljkovic E | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Verrey F | |||||||||
| SMap | S_parent | Sequence | F27C8 | ||||||
| Identity | Version | 1 | |||||||
| Name | CGC_name | aat-1 | |||||||
| Sequence_name | F27C8.1 | ||||||||
| Molecular_name | F27C8.1 | ||||||||
| F27C8.1.1 | |||||||||
| CE03266 | |||||||||
| Other_name | CELE_F27C8.1 | Accession_evidence | NDB | BX284604 | |||||
| Public_name | aat-1 | ||||||||
| DB_info | Database | AceView | gene | 4K364 | |||||
| WormQTL | gene | WBGene00000002 | |||||||
| WormFlux | gene | WBGene00000002 | |||||||
| NDB | locus_tag | CELE_F27C8.1 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00000002|UniProtKB=Q19834 | |||||||
| family | PTHR11785 | ||||||||
| NCBI | gene | 177793 | |||||||
| RefSeq | protein | NM_069306.7 | |||||||
| TrEMBL | UniProtAcc | Q19834 | |||||||
| UniProt_GCRP | UniProtAcc | Q19834 | |||||||
| OMIM | gene | 603593 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:19 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | aat | ||||||||
| Allele (38) | |||||||||
| Strain | WBStrain00054846 | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (11) | |||||||||
| Ortholog (62) | |||||||||
| Paralog (12) | |||||||||
| Structured_description | Concise_description | aat-1 encodes an amino acid transporter catalytic subunit; when co-expressed in Xenopus oocytes with the ATG-2 glycoprotein subunit, AAT-1 is able to facilitate amino acid uptake and exchange, showing a relatively high affinity for small and some large neutral amino acids; in addition, AAT-1 is able to covalently associate with ATG-2 or ATG-1 to form heterodimers in the Xenopus expression system; when co-expressed with ATG-2, AAT-1 localizes to the cell surface of oocytes, but when expressed alone or with ATG-1, AAT-1 localizes intracellularly. | Paper_evidence | WBPaper00006408 | |||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 02 Mar 2006 00:00:00 | ||||||||
| Automated_description | Contributes to L-amino acid transmembrane transporter activity. Involved in amino acid transmembrane transport. Located in plasma membrane. Part of amino acid transport complex. Expressed in egg-laying apparatus; head motor neurons; and tail. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); glioblastoma; and lysinuric protein intolerance. Is an ortholog of human SLC7A8 (solute carrier family 7 member 8). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model (26) | ||||||||
| Molecular_info | Corresponding_CDS | F27C8.1 | |||||||
| Corresponding_transcript | F27C8.1.1 | ||||||||
| Other_sequence (63) | |||||||||
| Associated_feature (11) | |||||||||
| Experimental_info | RNAi_result | WBRNAi00087502 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00045732 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00031488 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00113611 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00013991 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00112392 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Chronogram1135 | ||||||||
| Expr5887 | |||||||||
| Expr15194 | |||||||||
| Expr1023109 | |||||||||
| Expr1030001 | |||||||||
| Expr1149639 | |||||||||
| Expr2009064 | |||||||||
| Expr2027300 | |||||||||
| Drives_construct | WBCnstr00003611 | ||||||||
| WBCnstr00037804 | |||||||||
| WBCnstr00042037 | |||||||||
| Construct_product | WBCnstr00037804 | ||||||||
| WBCnstr00042037 | |||||||||
| Antibody | WBAntibody00000717 | ||||||||
| Microarray_results (18) | |||||||||
| Expression_cluster (209) | |||||||||
| Interaction (13) | |||||||||
| Map_info | Map | IV | Position | 4.33112 | Error | 0.001998 | |||
| Positive | Positive_clone | F27C8 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference (10) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
