WormBase Tree Display for Gene: WBGene00000002
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WBGene00000002 | Evidence | Author_evidence | Veljkovic E | ||||||
---|---|---|---|---|---|---|---|---|---|
Verrey F | |||||||||
SMap | S_parent | Sequence | F27C8 | ||||||
Identity | Version | 1 | |||||||
Name | CGC_name | aat-1 | |||||||
Sequence_name | F27C8.1 | ||||||||
Molecular_name | F27C8.1 | ||||||||
F27C8.1.1 | |||||||||
CE03266 | |||||||||
Other_name | CELE_F27C8.1 | Accession_evidence | NDB | BX284604 | |||||
Public_name | aat-1 | ||||||||
DB_info | Database | AceView | gene | 4K364 | |||||
WormQTL | gene | WBGene00000002 | |||||||
WormFlux | gene | WBGene00000002 | |||||||
NDB | locus_tag | CELE_F27C8.1 | |||||||
Panther | gene | CAEEL|WormBase=WBGene00000002|UniProtKB=Q19834 | |||||||
family | PTHR11785 | ||||||||
NCBI | gene | 177793 | |||||||
RefSeq | protein | NM_069306.7 | |||||||
TrEMBL | UniProtAcc | Q19834 | |||||||
UniProt_GCRP | UniProtAcc | Q19834 | |||||||
OMIM | gene | 603593 | |||||||
Species | Caenorhabditis elegans | ||||||||
History | Version_change | 1 | 07 Apr 2004 11:29:19 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
Status | Live | ||||||||
Gene_info | Biotype | SO:0001217 | |||||||
Gene_class | aat | ||||||||
Allele (38) | |||||||||
Strain | WBStrain00054846 | ||||||||
RNASeq_FPKM (74) | |||||||||
GO_annotation (11) | |||||||||
Ortholog (62) | |||||||||
Paralog (12) | |||||||||
Structured_description | Concise_description | aat-1 encodes an amino acid transporter catalytic subunit; when co-expressed in Xenopus oocytes with the ATG-2 glycoprotein subunit, AAT-1 is able to facilitate amino acid uptake and exchange, showing a relatively high affinity for small and some large neutral amino acids; in addition, AAT-1 is able to covalently associate with ATG-2 or ATG-1 to form heterodimers in the Xenopus expression system; when co-expressed with ATG-2, AAT-1 localizes to the cell surface of oocytes, but when expressed alone or with ATG-1, AAT-1 localizes intracellularly. | Paper_evidence | WBPaper00006408 | |||||
Curator_confirmed | WBPerson1843 | ||||||||
WBPerson567 | |||||||||
Date_last_updated | 02 Mar 2006 00:00:00 | ||||||||
Automated_description | Contributes to L-amino acid transmembrane transporter activity. Involved in amino acid transmembrane transport. Located in plasma membrane. Part of amino acid transport complex. Expressed in egg-laying apparatus; head motor neurons; and tail. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); glioblastoma; and lysinuric protein intolerance. Is an ortholog of human SLC7A8 (solute carrier family 7 member 8). | Paper_evidence | WBPaper00065943 | ||||||
Curator_confirmed | WBPerson324 | ||||||||
WBPerson37462 | |||||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
Disease_info | Potential_model (26) | ||||||||
Molecular_info | Corresponding_CDS | F27C8.1 | |||||||
Corresponding_transcript | F27C8.1.1 | ||||||||
Other_sequence | FC550046.1 | ||||||||
GR11189 | |||||||||
JO468690.1 | |||||||||
FK805841.1 | |||||||||
Acan_isotig08713 | |||||||||
EX557772.1 | |||||||||
FC546662.1 | |||||||||
EX549343.1 | |||||||||
EX556798.1 | |||||||||
BQ804129.1 | |||||||||
PTC03694_1 | |||||||||
EV850125.1 | |||||||||
Oden_isotig24704 | |||||||||
EX912143.1 | |||||||||
Acan_isotig01662 | |||||||||
Dviv_isotig28562 | |||||||||
ACC10374_1 | |||||||||
GRC03433_1 | |||||||||
FC547488.1 | |||||||||
MJ00278 | |||||||||
EX542246.1 | |||||||||
HBC17499_1 | |||||||||
CRC05684_1 | |||||||||
BMC00821_1 | |||||||||
GPC03116_1 | |||||||||
MJC01342_1 | |||||||||
EY462840.1 | |||||||||
PT03968 | |||||||||
BXC00077_1 | |||||||||
XI03205 | |||||||||
FC541392.1 | |||||||||
BXC04476_1 | |||||||||
GP02071 | |||||||||
GR13259 | |||||||||
Oden_isotig13676 | |||||||||
SRC05005_1 | |||||||||
Dviv_contig08851 | |||||||||
Hbac_isotig07420 | |||||||||
XIC02648_1 | |||||||||
FC819421.1 | |||||||||
Oden_isotig13675 | |||||||||
JI167427.1 | |||||||||
XI02438 | |||||||||
DVC01649_1 | |||||||||
CR05114 | |||||||||
XIC01902_1 | |||||||||
JI462101.1 | |||||||||
ACC02132_1 | |||||||||
Acan_isotig01661 | |||||||||
Acan_isotig01660 | |||||||||
Acan_isotig17563 | |||||||||
Hbac_isotig07121 | |||||||||
Oden_isotig27108 | |||||||||
EX911715.1 | |||||||||
ACC03564_1 | |||||||||
Hbac_isotig04729 | |||||||||
Oden_isotig26720 | |||||||||
Oden_isotig22817 | |||||||||
GRC02405_1 | |||||||||
HBC11156_1 | |||||||||
FC819076.1 | |||||||||
JI476171.1 | |||||||||
EX554321.1 | |||||||||
Associated_feature (11) | |||||||||
Experimental_info | RNAi_result | WBRNAi00087502 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00045732 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00031488 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00113611 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00013991 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00112392 | Inferred_automatically | RNAi_primary | |||||||
Expr_pattern | Chronogram1135 | ||||||||
Expr5887 | |||||||||
Expr15194 | |||||||||
Expr1023109 | |||||||||
Expr1030001 | |||||||||
Expr1149639 | |||||||||
Expr2009064 | |||||||||
Expr2027300 | |||||||||
Drives_construct | WBCnstr00003611 | ||||||||
WBCnstr00037804 | |||||||||
WBCnstr00042037 | |||||||||
Construct_product | WBCnstr00037804 | ||||||||
WBCnstr00042037 | |||||||||
Antibody | WBAntibody00000717 | ||||||||
Microarray_results (18) | |||||||||
Expression_cluster (209) | |||||||||
Interaction (13) | |||||||||
Map_info | Map | IV | Position | 4.33112 | Error | 0.001998 | |||
Positive | Positive_clone | F27C8 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
Pseudo_map_position | |||||||||
Reference | WBPaper00006408 | ||||||||
WBPaper00024381 | |||||||||
WBPaper00035475 | |||||||||
WBPaper00038491 | |||||||||
WBPaper00042390 | |||||||||
WBPaper00045095 | |||||||||
WBPaper00050950 | |||||||||
WBPaper00053894 | |||||||||
WBPaper00055090 | |||||||||
WBPaper00060013 | |||||||||
Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
Method | Gene |