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WormBase Tree Display for Variation: WBVar00143953

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Name Class

WBVar00143953EvidencePerson_evidenceWBPerson25803
NamePublic_namee1376
Other_nameCE50691:p.Pro423GlnfsTer51
F25E2.5e.1:c.1511del
CE50852:p.Pro426GlnfsTer51
CE26364:p.Pro439GlnfsTer51
F25E2.5c.1:c.1316del
F25E2.5h.1:c.1268del
F25E2.5b.1:c.1520del
F25E2.5f.1:c.1502del
F25E2.5g.1:c.1277del
CE28003:p.Pro501GlnfsTer51
CE30963:p.Pro507GlnfsTer51
CE28002:p.Pro535GlnfsTer51
CE50732:p.Pro504GlnfsTer51
F25E2.5d.1:c.1613del
F25E2.5a.1:c.1604del
CE50706:p.Pro538GlnfsTer51
HGVSgCHROMOSOME_X:g.822069del
Sequence_detailsSMapS_parentSequenceF25E2
Flanking_sequencesACCATACGTCCCAACAAGGCAGTCATCAACAGGGCACCAAGGTCAGGTACCGAATGATCC
Mapping_targetF25E2
Type_of_mutationDeletion
SeqStatusSequenced
Variation_typeAllele
OriginSpeciesCaenorhabditis elegans
StrainWBStrain00004312
WBStrain00004377
WBStrain00026945
WBStrain00030757
WBStrain00035151
LaboratoryCB
StatusLive
AffectsGeneWBGene00000899
TranscriptF25E2.5g.1VEP_consequenceframeshift_variant
VEP_impactHIGH
HGVScF25E2.5g.1:c.1277del
HGVSpCE50852:p.Pro426GlnfsTer51
cDNA_position1277
CDS_position1277
Protein_position426
Exon_number5/12
Codon_changecCa/ca
Amino_acid_changeP/X
F25E2.5d.1VEP_consequenceframeshift_variant
VEP_impactHIGH
HGVScF25E2.5d.1:c.1613del
HGVSpCE50706:p.Pro538GlnfsTer51
cDNA_position1613
CDS_position1613
Protein_position538
Exon_number8/15
Codon_changecCa/ca
Amino_acid_changeP/X
F25E2.5e.1VEP_consequenceframeshift_variant
VEP_impactHIGH
HGVScF25E2.5e.1:c.1511del
HGVSpCE50732:p.Pro504GlnfsTer51
cDNA_position1560
CDS_position1511
Protein_position504
Exon_number8/16
Codon_changecCa/ca
Amino_acid_changeP/X
F25E2.5b.1VEP_consequenceframeshift_variant
VEP_impactHIGH
HGVScF25E2.5b.1:c.1520del
HGVSpCE30963:p.Pro507GlnfsTer51
cDNA_position1567
CDS_position1520
Protein_position507
Exon_number8/16
Codon_changecCa/ca
Amino_acid_changeP/X
F25E2.5f.1VEP_consequenceframeshift_variant
VEP_impactHIGH
HGVScF25E2.5f.1:c.1502del
HGVSpCE28003:p.Pro501GlnfsTer51
cDNA_position1550
CDS_position1502
Protein_position501
Exon_number8/16
Codon_changecCa/ca
Amino_acid_changeP/X
F25E2.5a.1VEP_consequenceframeshift_variant
VEP_impactHIGH
HGVScF25E2.5a.1:c.1604del
HGVSpCE28002:p.Pro535GlnfsTer51
cDNA_position1653
CDS_position1604
Protein_position535
Exon_number9/17
Codon_changecCa/ca
Amino_acid_changeP/X
F25E2.5c.1VEP_consequenceframeshift_variant
VEP_impactHIGH
HGVScF25E2.5c.1:c.1316del
HGVSpCE26364:p.Pro439GlnfsTer51
cDNA_position1321
CDS_position1316
Protein_position439
Exon_number6/14
Codon_changecCa/ca
Amino_acid_changeP/X
F25E2.5h.1VEP_consequenceframeshift_variant
VEP_impactHIGH
HGVScF25E2.5h.1:c.1268del
HGVSpCE50691:p.Pro423GlnfsTer51
cDNA_position1268
CDS_position1268
Protein_position423
Exon_number5/12
Codon_changecCa/ca
Amino_acid_changeP/X
InteractorWBInteraction000051076
WBInteraction000051077
WBInteraction000051078
WBInteraction000051079
WBInteraction000051080
WBInteraction000051081
WBInteraction000051082
WBInteraction000051083
WBInteraction000051084
WBInteraction000051085
WBInteraction000051086
WBInteraction000051087
WBInteraction000051088
WBInteraction000051089
WBInteraction000051090
WBInteraction000051091
WBInteraction000051092
WBInteraction000051093
WBInteraction000051094
WBInteraction000051095
WBInteraction000051096
WBInteraction000051097
WBInteraction000051098
WBInteraction000051099
WBInteraction000051100
WBInteraction000051101
WBInteraction000051102
WBInteraction000051103
WBInteraction000051104
WBInteraction000051105
WBInteraction000051106
WBInteraction000051107
WBInteraction000051108
WBInteraction000051109
WBInteraction000051110
WBInteraction000051111
WBInteraction000051112
WBInteraction000051113
WBInteraction000051114
WBInteraction000051115
WBInteraction000051116
WBInteraction000051117
WBInteraction000051118
WBInteraction000051119
WBInteraction000051120
WBInteraction000051121
WBInteraction000052359
WBInteraction000052361
WBInteraction000052362
WBInteraction000052446
WBInteraction000052447
WBInteraction000052449
WBInteraction000052451
WBInteraction000052453
WBInteraction000052455
WBInteraction000518469
WBInteraction000523951
WBInteraction000536042
WBInteraction000536053
GeneticsInterpolated_map_positionX-19.4991
Mapping_dataIn_2_point299
413
414
DescriptionPhenotypeWBPhenotype:0000013Paper_evidenceWBPaper00000316
WBPaper00000504
Person_evidenceWBPerson261
Curator_confirmedWBPerson712
Remarkdefective dauer formationPerson_evidenceWBPerson261
Curator_confirmedWBPerson712
Ease_of_scoringES1_Very_hard_to_scorePerson_evidenceWBPerson261
Curator_confirmedWBPerson712
WBPhenotype:0000061Paper_evidenceWBPaper00038374
Curator_confirmedWBPerson2987
Remark"When compared to the daf-2(e1370) parental strain, daf-2(e1370); daf-3(mgDf90) mutants lived significantly longer. This was also observed in daf-2(e1370); daf-3(e1376) worms, which is a weaker allele of daf-3." (see Figure 4A)Paper_evidenceWBPaper00038374
Curator_confirmedWBPerson2987
Phenotype_assayGenotypedaf-2(e1370)Paper_evidenceWBPaper00038374
Curator_confirmedWBPerson2987
WBPhenotype:0000135Paper_evidenceWBPaper00035610
Curator_confirmedWBPerson2021
Remarkdaf-8 and daf-7 transcripts were upregulated in daf-3 mutants. However, lag-2 expression was not significantly changed in daf-3 mutantsPaper_evidenceWBPaper00035610
Curator_confirmedWBPerson2021
Variation_effectProbable_null_via_phenotypePaper_evidenceWBPaper00035610
Curator_confirmedWBPerson2021
Phenotype_assayTreatmentqRT-PCRPaper_evidenceWBPaper00035610
Curator_confirmedWBPerson2021
WBPhenotype:0000542Paper_evidenceWBPaper00043908
Curator_confirmedWBPerson2987
WBPhenotype:0000637Paper_evidenceWBPaper00038374
Curator_confirmedWBPerson2987
Remarkdaf-3(e1376) enhances the constitutive dauer formation phenotype of daf-2(e1370) (Figure S11A, S11C)Paper_evidenceWBPaper00038374
Curator_confirmedWBPerson2987
Phenotype_assayGenotypedaf-2(e1370)Paper_evidenceWBPaper00038374
Curator_confirmedWBPerson2987
WBPhenotype:0001692Paper_evidenceWBPaper00002589
Curator_confirmedWBPerson712
RemarkAnimals did not display the L2 M37 epitope to the same extent as wildtype when grown in the presence of pheromone, e.g. animals were ILD defective.Paper_evidenceWBPaper00002589
Curator_confirmedWBPerson712
WBPhenotype:0002285Paper_evidenceWBPaper00043908
Curator_confirmedWBPerson2987
WBPhenotype:0002288Paper_evidenceWBPaper00043908
Curator_confirmedWBPerson2987
WBPhenotype:0002292Paper_evidenceWBPaper00043908
Curator_confirmedWBPerson2987
WBPhenotype:0002299Paper_evidenceWBPaper00043908
Curator_confirmedWBPerson2987
WBPhenotype:0002301Paper_evidenceWBPaper00043908
Curator_confirmedWBPerson2987
WBPhenotype:0002312Paper_evidenceWBPaper00043908
Curator_confirmedWBPerson2987
WBPhenotype:0002319Paper_evidenceWBPaper00043908
Curator_confirmedWBPerson2987
WBPhenotype:0002323Paper_evidenceWBPaper00043908
Curator_confirmedWBPerson2987
WBPhenotype:0002344Paper_evidenceWBPaper00043908
Curator_confirmedWBPerson2987
WBPhenotype:0004022Paper_evidenceWBPaper00043908
Curator_confirmedWBPerson2987
WBPhenotype:0004023Paper_evidenceWBPaper00043908
Curator_confirmedWBPerson2987
Phenotype_not_observedWBPhenotype:0000061Paper_evidenceWBPaper00005086
Curator_confirmedWBPerson712
Phenotype_assayTemperature15CPaper_evidenceWBPaper00005086
Curator_confirmedWBPerson712
WBPhenotype:0000256Paper_evidenceWBPaper00000316
Curator_confirmedWBPerson712
WBPhenotype:0000306Paper_evidenceWBPaper00032073
Curator_confirmedWBPerson712
RemarkThe expression of cuIs5 (or cuIs2), a reporter of TGF-beta -signaling activity, remains at wild type levels.Paper_evidenceWBPaper00032073
Curator_confirmedWBPerson712
Phenotype_assayGenotypecuIs5 or cuIs2Paper_evidenceWBPaper00032073
Curator_confirmedWBPerson712
WBPhenotype:0000520Paper_evidenceWBPaper00000316
Curator_confirmedWBPerson712
WBPhenotype:0000660Paper_evidenceWBPaper00005511
Curator_confirmedWBPerson2021
Remarkdaf-3 mutants do not aggregate and border on foodPaper_evidenceWBPaper00005511
Curator_confirmedWBPerson2021
WBPhenotype:0000823Paper_evidenceWBPaper00035610
Curator_confirmedWBPerson2021
RemarkThe mitotic region of daf-3(e1376) was indistinguishable from that of the wild typePaper_evidenceWBPaper00035610
Curator_confirmedWBPerson2021
Phenotype_assayTreatmentDAPI stainingPaper_evidenceWBPaper00035610
Curator_confirmedWBPerson2021
WBPhenotype:0001040Paper_evidenceWBPaper00000316
Curator_confirmedWBPerson712
WBPhenotype:0001690Paper_evidenceWBPaper00002589
Curator_confirmedWBPerson712
RemarkAnimals were positive for mAb M37 at the L1 stage but not at any other stage, similar to N2 animals.Paper_evidenceWBPaper00002589
Curator_confirmedWBPerson712
PenetranceLowPaper_evidenceWBPaper00002589
Curator_confirmedWBPerson712
Phenotype_assayTemperature27.5Paper_evidenceWBPaper00002589
Curator_confirmedWBPerson712
WBPhenotype:0001999Paper_evidenceWBPaper00037970
Curator_confirmedWBPerson2987
RemarkThe integration of signals for attraction to diacetyl (100x dilute) and avoidance from copper (100 millimolar) was normal (like wild type) in daf-3(e1376) mutants, resulting in the same number of animals crossing the copper barrier to get to the diacetyl spot compared to wild type controls (Figure 5)Paper_evidenceWBPaper00037970
Curator_confirmedWBPerson2987
Affected_byMoleculeWBMol:00002819Paper_evidenceWBPaper00037970
Curator_confirmedWBPerson2987
WBMol:00002862Paper_evidenceWBPaper00037970
Curator_confirmedWBPerson2987
WBPhenotype:0002535Paper_evidenceWBPaper00000932
Curator_confirmedWBPerson712
RemarkFITC uptake is normal.Paper_evidenceWBPaper00000932
Curator_confirmedWBPerson712
ReferenceWBPaper00037970
WBPaper00038374
WBPaper00043908
WBPaper00000504
WBPaper00000932
WBPaper00014521
WBPaper00002589
WBPaper00005086
WBPaper00021876
WBPaper00000316
WBPaper00015224
WBPaper00016006
WBPaper00032073
WBPaper00005511
WBPaper00035610
WBPaper00016610
WBPaper00045859
MethodDeletion_allele