WormBase Tree Display for Interaction: WBInteraction000502594
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| WBInteraction000502594 | Interaction_type | Regulatory | Change_of_expression_level | ||
|---|---|---|---|---|---|
| Interactor | Interactor_overlapping_gene | WBGene00003058 | Interactor_type | Trans_regulator | |
| WBGene00004035 | Interactor_type | Trans_regulated | |||
| Expr_pattern | Expr3490 | ||||
| Variation_interactor | WBVar00249016 | Interactor_type | Trans_regulator | ||
| Interaction_summary | In wild type, PKD-2::GFP localizes predominantly to cell bodies and cilia, and is also observed in small dendritic and axonal puncta. In lov-1 mutants, PKD-2 is often absent from RnB cilia. In both the CEMs and RnBs of a lov-1 mutant, PKD-2::GFP forms one or two large aggregates in cell bodies. This aggregation phenotype is more severe in RnBs than CEMs. | ||||
| Detection_method | Reporter_gene | [pkd-2::gfp], translational fusion of pkd-2(cDNA) with GFP, driven by pkd-2 promoter. | |||
| Regulation_result | Positive_regulate | Anatomy_term (20) | |||
| Subcellular_localization | PKD-2::GFP localizes in the cell bodies, small dendritic and axonal puncta, and ciliary endings | ||||
| Paper | WBPaper00028448 | ||||
| Remark | LOV-1 plays a tissue-specific role and is required for efficient somatodendritic and ciliary targeting of PKD-2 in ray but not CEM neurons. |
