WormBase Tree Display for Variation: WBVar00249016
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WBVar00249016 | Name | Public_name | sy582 | ||||||
---|---|---|---|---|---|---|---|---|---|
Sequence_details | SeqStatus | Pending_curation | |||||||
Variation_type | Allele | ||||||||
Origin | Species | Caenorhabditis elegans | |||||||
Strain | WBStrain00030885 | ||||||||
WBStrain00030886 | |||||||||
Laboratory | PS | ||||||||
Status | Live | ||||||||
Affects | Gene | WBGene00003058 | |||||||
Interactor | WBInteraction000502594 | ||||||||
WBInteraction000504327 | |||||||||
WBInteraction000518568 | |||||||||
WBInteraction000519222 | |||||||||
Description | Phenotype | WBPhenotype:0000649 | Paper_evidence | WBPaper00003680 | |||||
WBPaper00024944 | |||||||||
Curator_confirmed | WBPerson712 | ||||||||
Remark | males are defective in vulva-location behavior | Paper_evidence | WBPaper00003680 | ||||||
Curator_confirmed | WBPerson712 | ||||||||
mutants exhibit 25% vulva location efficiency | Paper_evidence | WBPaper00024944 | |||||||
Curator_confirmed | WBPerson712 | ||||||||
Recessive | Paper_evidence | WBPaper00003680 | |||||||
Curator_confirmed | WBPerson712 | ||||||||
Variation_effect | Null | Paper_evidence | WBPaper00003680 | ||||||
Curator_confirmed | WBPerson712 | ||||||||
WBPhenotype:0000679 | Paper_evidence | WBPaper00028448 | |||||||
Curator_confirmed | WBPerson712 | ||||||||
Remark | In both the CEMs and RnBs of a lov-1 mutant, PKD-2::GFP forms one or two large aggregates in cell bodies. This aggregation phenotype is more severe in RnBs than CEMs. | Punc-119::PKD-2::GFP RnB ciliary localization was often lost. In lov-1 mutants, Punc-119::PKD-2::GFP aggregates are only observed in RnB, HOB and CEM cell bodies. | Paper_evidence | WBPaper00028448 | ||||||
Curator_confirmed | WBPerson712 | ||||||||
EQ_annotations | Anatomy_term | WBbt:0006941 | PATO:0000460 | Paper_evidence | WBPaper00028448 | ||||
Curator_confirmed | WBPerson712 | ||||||||
WBbt:0005246 | PATO:0000460 | Paper_evidence | WBPaper00028448 | ||||||
Curator_confirmed | WBPerson712 | ||||||||
WBPhenotype:0000962 | Paper_evidence | WBPaper00004854 | |||||||
WBPaper00028448 | |||||||||
Curator_confirmed | WBPerson712 | ||||||||
Remark | A decrease in the overall level of PKD-2 was observed in dendrites and sensory endings of the ray and CEM neurons. | Paper_evidence | WBPaper00004854 | ||||||
Curator_confirmed | WBPerson712 | ||||||||
In CEMs, PKD-2::GFP ciliary abundance in a lov-1 background is not significantly different from wild type. In rays, however, PKD-2 is often absent from RnB cilia. Moreover, the fluorescence intensity in those ray cilia with detectable PKD-2::GFP is largely reduced compared with wild type. | Punc-119::PKD-2::GFP fluorescence intensity in ray cilia is reduced compared with wild type. | Paper_evidence | WBPaper00028448 | |||||||
Curator_confirmed | WBPerson712 | ||||||||
Variation_effect | Null | Paper_evidence | WBPaper00004854 | ||||||
Curator_confirmed | WBPerson712 | ||||||||
EQ_annotations | Anatomy_term | WBbt:0006941 | PATO:0000460 | Paper_evidence | WBPaper00028448 | ||||
Curator_confirmed | WBPerson712 | ||||||||
Life_stage | WBls:0000056 | PATO:0000460 | Paper_evidence | WBPaper00004854 | |||||
Curator_confirmed | WBPerson712 | ||||||||
Phenotype_assay | Genotype | WBPaper00004854Ex1 [pkd-2(+)::gfp4] | Paper_evidence | WBPaper00004854 | |||||
Curator_confirmed | WBPerson712 | ||||||||
WBPhenotype:0002128 | Paper_evidence | WBPaper00032414 | |||||||
Curator_confirmed | WBPerson2817 | ||||||||
WBPhenotype:0002130 | Paper_evidence | WBPaper00041718 | |||||||
Curator_confirmed | WBPerson712 | ||||||||
Remark | Mate-searching behavior was reduced. | Paper_evidence | WBPaper00041718 | ||||||
Curator_confirmed | WBPerson712 | ||||||||
WBPhenotype:0004004 | Paper_evidence | WBPaper00003680 | |||||||
Curator_confirmed | WBPerson712 | ||||||||
Remark | males are response defective | Paper_evidence | WBPaper00003680 | ||||||
Curator_confirmed | WBPerson712 | ||||||||
Recessive | Paper_evidence | WBPaper00003680 | |||||||
Curator_confirmed | WBPerson712 | ||||||||
Variation_effect | Null | Paper_evidence | WBPaper00003680 | ||||||
Curator_confirmed | WBPerson712 | ||||||||
WBPhenotype:0004030 | Paper_evidence | WBPaper00024944 | |||||||
Curator_confirmed | WBPerson712 | ||||||||
Remark | mutants exhibit 25% response efficiency | Paper_evidence | WBPaper00024944 | ||||||
Curator_confirmed | WBPerson712 | ||||||||
Phenotype_not_observed | WBPhenotype:0000637 | Paper_evidence | WBPaper00004854 | ||||||
Curator_confirmed | WBPerson712 | ||||||||
Remark | mutants are wild-type for this behavior | Paper_evidence | WBPaper00004854 | ||||||
Curator_confirmed | WBPerson712 | ||||||||
Variation_effect | Null | Paper_evidence | WBPaper00004854 | ||||||
Curator_confirmed | WBPerson712 | ||||||||
WBPhenotype:0000640 | Paper_evidence | WBPaper00004854 | |||||||
Curator_confirmed | WBPerson712 | ||||||||
Remark | mutants are wild-type for this behavior | Paper_evidence | WBPaper00004854 | ||||||
Curator_confirmed | WBPerson712 | ||||||||
Variation_effect | Null | Paper_evidence | WBPaper00004854 | ||||||
Curator_confirmed | WBPerson712 | ||||||||
WBPhenotype:0000652 | Paper_evidence | WBPaper00004854 | |||||||
Curator_confirmed | WBPerson712 | ||||||||
Remark | The sensory endings of HOB and Ray RnB are normal. | Paper_evidence | WBPaper00004854 | ||||||
Curator_confirmed | WBPerson712 | ||||||||
Variation_effect | Null | Paper_evidence | WBPaper00004854 | ||||||
Curator_confirmed | WBPerson712 | ||||||||
EQ_annotations | Anatomy_term | WBbt:0004761 | PATO:0000460 | Paper_evidence | WBPaper00004854 | ||||
Curator_confirmed | WBPerson712 | ||||||||
WBbt:0006941 | PATO:0000460 | Paper_evidence | WBPaper00004854 | ||||||
Curator_confirmed | WBPerson712 | ||||||||
Life_stage | WBls:0000056 | PATO:0000460 | Paper_evidence | WBPaper00004854 | |||||
Curator_confirmed | WBPerson712 | ||||||||
WBPhenotype:0000663 | Paper_evidence | WBPaper00004854 | |||||||
Curator_confirmed | WBPerson712 | ||||||||
Remark | mutants are wild-type for this behavior | Paper_evidence | WBPaper00004854 | ||||||
Curator_confirmed | WBPerson712 | ||||||||
Variation_effect | Null | Paper_evidence | WBPaper00004854 | ||||||
Curator_confirmed | WBPerson712 | ||||||||
WBPhenotype:0000853 | Paper_evidence | WBPaper00028448 | |||||||
Curator_confirmed | WBPerson712 | ||||||||
Remark | PKD-2::GFP particles exhibit similar bidirectional movement as wild type in the lov-1 dendrite. | Paper_evidence | WBPaper00028448 | ||||||
Curator_confirmed | WBPerson712 | ||||||||
WBPhenotype:0001403 | Paper_evidence | WBPaper00004854 | |||||||
Curator_confirmed | WBPerson712 | ||||||||
Remark | no obvious difference in PKD-2 localization was observed in three separate fixations. PKD-2 localization is not dependent on LOV-1 function. | Paper_evidence | WBPaper00004854 | ||||||
Curator_confirmed | WBPerson712 | ||||||||
Variation_effect | Null | Paper_evidence | WBPaper00004854 | ||||||
Curator_confirmed | WBPerson712 | ||||||||
EQ_annotations | Life_stage | WBls:0000056 | PATO:0000460 | Paper_evidence | WBPaper00004854 | ||||
Curator_confirmed | WBPerson712 | ||||||||
Phenotype_assay | Genotype | WBPaper00004854Ex1 [pkd-2(+)::gfp4] | Paper_evidence | WBPaper00004854 | |||||
Curator_confirmed | WBPerson712 | ||||||||
WBPhenotype:0002535 | Paper_evidence | WBPaper00004854 | |||||||
Curator_confirmed | WBPerson712 | ||||||||
Remark | mutants are wild-type for this behavior | Paper_evidence | WBPaper00004854 | ||||||
Curator_confirmed | WBPerson712 | ||||||||
Variation_effect | Null | Paper_evidence | WBPaper00004854 | ||||||
Curator_confirmed | WBPerson712 | ||||||||
Disease_info | Models_disease | DOID:898 | |||||||
Models_disease_in_annotation | WBDOannot00000512 | ||||||||
WBDOannot00000516 | |||||||||
Reference | WBPaper00041718 | ||||||||
WBPaper00029013 | |||||||||
WBPaper00028448 | |||||||||
WBPaper00004854 | |||||||||
WBPaper00003680 | |||||||||
WBPaper00024944 | |||||||||
WBPaper00032414 | |||||||||
Method | Allele |