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WormBase Tree Display for Variation: WBVar00249016

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Name Class

WBVar00249016NamePublic_namesy582
Sequence_detailsSeqStatusPending_curation
Variation_typeAllele
OriginSpeciesCaenorhabditis elegans
StrainWBStrain00030885
WBStrain00030886
LaboratoryPS
StatusLive
AffectsGeneWBGene00003058
InteractorWBInteraction000502594
WBInteraction000504327
WBInteraction000518568
WBInteraction000519222
DescriptionPhenotypeWBPhenotype:0000649Paper_evidenceWBPaper00003680
WBPaper00024944
Curator_confirmedWBPerson712
Remarkmales are defective in vulva-location behaviorPaper_evidenceWBPaper00003680
Curator_confirmedWBPerson712
mutants exhibit 25% vulva location efficiencyPaper_evidenceWBPaper00024944
Curator_confirmedWBPerson712
RecessivePaper_evidenceWBPaper00003680
Curator_confirmedWBPerson712
Variation_effectNullPaper_evidenceWBPaper00003680
Curator_confirmedWBPerson712
WBPhenotype:0000679Paper_evidenceWBPaper00028448
Curator_confirmedWBPerson712
RemarkIn both the CEMs and RnBs of a lov-1 mutant, PKD-2::GFP forms one or two large aggregates in cell bodies. This aggregation phenotype is more severe in RnBs than CEMs. | Punc-119::PKD-2::GFP RnB ciliary localization was often lost. In lov-1 mutants, Punc-119::PKD-2::GFP aggregates are only observed in RnB, HOB and CEM cell bodies.Paper_evidenceWBPaper00028448
Curator_confirmedWBPerson712
EQ_annotationsAnatomy_termWBbt:0006941PATO:0000460Paper_evidenceWBPaper00028448
Curator_confirmedWBPerson712
WBbt:0005246PATO:0000460Paper_evidenceWBPaper00028448
Curator_confirmedWBPerson712
WBPhenotype:0000962Paper_evidenceWBPaper00004854
WBPaper00028448
Curator_confirmedWBPerson712
RemarkA decrease in the overall level of PKD-2 was observed in dendrites and sensory endings of the ray and CEM neurons.Paper_evidenceWBPaper00004854
Curator_confirmedWBPerson712
In CEMs, PKD-2::GFP ciliary abundance in a lov-1 background is not significantly different from wild type. In rays, however, PKD-2 is often absent from RnB cilia. Moreover, the fluorescence intensity in those ray cilia with detectable PKD-2::GFP is largely reduced compared with wild type. | Punc-119::PKD-2::GFP fluorescence intensity in ray cilia is reduced compared with wild type.Paper_evidenceWBPaper00028448
Curator_confirmedWBPerson712
Variation_effectNullPaper_evidenceWBPaper00004854
Curator_confirmedWBPerson712
EQ_annotationsAnatomy_termWBbt:0006941PATO:0000460Paper_evidenceWBPaper00028448
Curator_confirmedWBPerson712
Life_stageWBls:0000056PATO:0000460Paper_evidenceWBPaper00004854
Curator_confirmedWBPerson712
Phenotype_assayGenotypeWBPaper00004854Ex1 [pkd-2(+)::gfp4]Paper_evidenceWBPaper00004854
Curator_confirmedWBPerson712
WBPhenotype:0002128Paper_evidenceWBPaper00032414
Curator_confirmedWBPerson2817
WBPhenotype:0002130Paper_evidenceWBPaper00041718
Curator_confirmedWBPerson712
RemarkMate-searching behavior was reduced.Paper_evidenceWBPaper00041718
Curator_confirmedWBPerson712
WBPhenotype:0004004Paper_evidenceWBPaper00003680
Curator_confirmedWBPerson712
Remarkmales are response defectivePaper_evidenceWBPaper00003680
Curator_confirmedWBPerson712
RecessivePaper_evidenceWBPaper00003680
Curator_confirmedWBPerson712
Variation_effectNullPaper_evidenceWBPaper00003680
Curator_confirmedWBPerson712
WBPhenotype:0004030Paper_evidenceWBPaper00024944
Curator_confirmedWBPerson712
Remarkmutants exhibit 25% response efficiencyPaper_evidenceWBPaper00024944
Curator_confirmedWBPerson712
Phenotype_not_observedWBPhenotype:0000637Paper_evidenceWBPaper00004854
Curator_confirmedWBPerson712
Remarkmutants are wild-type for this behaviorPaper_evidenceWBPaper00004854
Curator_confirmedWBPerson712
Variation_effectNullPaper_evidenceWBPaper00004854
Curator_confirmedWBPerson712
WBPhenotype:0000640Paper_evidenceWBPaper00004854
Curator_confirmedWBPerson712
Remarkmutants are wild-type for this behaviorPaper_evidenceWBPaper00004854
Curator_confirmedWBPerson712
Variation_effectNullPaper_evidenceWBPaper00004854
Curator_confirmedWBPerson712
WBPhenotype:0000652Paper_evidenceWBPaper00004854
Curator_confirmedWBPerson712
RemarkThe sensory endings of HOB and Ray RnB are normal.Paper_evidenceWBPaper00004854
Curator_confirmedWBPerson712
Variation_effectNullPaper_evidenceWBPaper00004854
Curator_confirmedWBPerson712
EQ_annotationsAnatomy_termWBbt:0004761PATO:0000460Paper_evidenceWBPaper00004854
Curator_confirmedWBPerson712
WBbt:0006941PATO:0000460Paper_evidenceWBPaper00004854
Curator_confirmedWBPerson712
Life_stageWBls:0000056PATO:0000460Paper_evidenceWBPaper00004854
Curator_confirmedWBPerson712
WBPhenotype:0000663Paper_evidenceWBPaper00004854
Curator_confirmedWBPerson712
Remarkmutants are wild-type for this behaviorPaper_evidenceWBPaper00004854
Curator_confirmedWBPerson712
Variation_effectNullPaper_evidenceWBPaper00004854
Curator_confirmedWBPerson712
WBPhenotype:0000853Paper_evidenceWBPaper00028448
Curator_confirmedWBPerson712
RemarkPKD-2::GFP particles exhibit similar bidirectional movement as wild type in the lov-1 dendrite.Paper_evidenceWBPaper00028448
Curator_confirmedWBPerson712
WBPhenotype:0001403Paper_evidenceWBPaper00004854
Curator_confirmedWBPerson712
Remarkno obvious difference in PKD-2 localization was observed in three separate fixations. PKD-2 localization is not dependent on LOV-1 function.Paper_evidenceWBPaper00004854
Curator_confirmedWBPerson712
Variation_effectNullPaper_evidenceWBPaper00004854
Curator_confirmedWBPerson712
EQ_annotationsLife_stageWBls:0000056PATO:0000460Paper_evidenceWBPaper00004854
Curator_confirmedWBPerson712
Phenotype_assayGenotypeWBPaper00004854Ex1 [pkd-2(+)::gfp4]Paper_evidenceWBPaper00004854
Curator_confirmedWBPerson712
WBPhenotype:0002535Paper_evidenceWBPaper00004854
Curator_confirmedWBPerson712
Remarkmutants are wild-type for this behaviorPaper_evidenceWBPaper00004854
Curator_confirmedWBPerson712
Variation_effectNullPaper_evidenceWBPaper00004854
Curator_confirmedWBPerson712
Disease_infoModels_diseaseDOID:898
Models_disease_in_annotationWBDOannot00000512
WBDOannot00000516
ReferenceWBPaper00041718
WBPaper00029013
WBPaper00028448
WBPaper00004854
WBPaper00003680
WBPaper00024944
WBPaper00032414
MethodAllele