WormBase Tree Display for Gene: WBGene00018857
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| WBGene00018857 | SMap | S_parent | Sequence | F55A4 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | stau-1 | Person_evidence | WBPerson1574 | |||||
| Sequence_name | F55A4.5 | ||||||||
| Molecular_name | F55A4.5 | ||||||||
| F55A4.5.1 | |||||||||
| CE11107 | |||||||||
| Other_name | CELE_F55A4.5 | Accession_evidence | NDB | BX284606 | |||||
| Public_name | stau-1 | ||||||||
| DB_info | Database | AceView | gene | XB646 | |||||
| WormQTL | gene | WBGene00018857 | |||||||
| WormFlux | gene | WBGene00018857 | |||||||
| NDB | locus_tag | CELE_F55A4.5 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00018857|UniProtKB=Q94239 | |||||||
| family | PTHR46054 | ||||||||
| NCBI | gene | 180455 | |||||||
| RefSeq | protein | NM_075795.5 | |||||||
| TREEFAM | TREEFAM_ID | TF350296 | |||||||
| TrEMBL | UniProtAcc | Q94239 | |||||||
| UniProt_GCRP | UniProtAcc | Q94239 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 28 May 2004 13:31:00 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of stlace from WS125 | ||
| 2 | 28 Jul 2008 09:58:13 | WBPerson2970 | Name_change | CGC_name | stau-1 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | stau | ||||||||
| Allele (115) | |||||||||
| Strain | WBStrain00003524 | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (19) | |||||||||
| Ortholog (41) | |||||||||
| Paralog | WBGene00000079 | Caenorhabditis elegans | From_analysis | WormBase-Compara | |||||
| WBGene00000080 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00008397 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00011253 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00022388 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| Structured_description | Concise_description | stau-1 encodes a double-stranded RNA (dsRNA)-binding protein orthologous to Drosophila Staufen and mammalian STAU1 and STAU2; STAU-1 binds dsRNA in vitro, showing preference for highly structured RNAs; genetic analyses suggest that stau-1 activity is required for regulation of gene expression, RNA interference, and, along with eri-1, germ cell development; STAU-1 is expressed at all developmental stages, with highest levels seen in embryos. | Paper_evidence | WBPaper00041771 | |||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 04 Jan 2013 00:00:00 | ||||||||
| Automated_description | Enables double-stranded RNA binding activity. Involved in germ cell development and negative regulation of post-transcriptional gene silencing by regulatory ncRNA. Predicted to be located in several cellular components, including cytoplasmic stress granule; neuron projection; and neuronal cell body. Predicted to be part of messenger ribonucleoprotein complex. Human ortholog(s) of this gene implicated in atherosclerosis. Is an ortholog of human STAU1 (staufen double-stranded RNA binding protein 1). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:1936 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11370) | ||||
| Molecular_info | Corresponding_CDS | F55A4.5 | |||||||
| Corresponding_transcript | F55A4.5.1 | ||||||||
| Other_sequence | Dviv_isotig16239 | ||||||||
| Tcol_isotig22348 | |||||||||
| Dviv_isotig16238 | |||||||||
| BMC05552_1 | |||||||||
| JI165268.1 | |||||||||
| Dviv_isotig15347 | |||||||||
| Associated_feature (13) | |||||||||
| Experimental_info | RNAi_result | WBRNAi00080631 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00015685 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00048438 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00032846 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Chronogram1066 | ||||||||
| Expr6195 | |||||||||
| Expr10656 | |||||||||
| Expr1020852 | |||||||||
| Expr1038137 | |||||||||
| Expr1152225 | |||||||||
| Expr2016954 | |||||||||
| Expr2035102 | |||||||||
| Drives_construct | WBCnstr00003982 | ||||||||
| WBCnstr00026237 | |||||||||
| Construct_product | WBCnstr00026237 | ||||||||
| Regulate_expr_cluster | WBPaper00049286:stau-1(tm2266)_downregulated | ||||||||
| WBPaper00049286:stau-1(tm2266)_upregulated | |||||||||
| Antibody | WBAntibody00002397 | ||||||||
| Microarray_results (19) | |||||||||
| Expression_cluster (100) | |||||||||
| Interaction (98) | |||||||||
| Map_info | Map | X | Position | -18.8218 | Error | 0.010026 | |||
| Positive | Positive_clone | F55A4 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference (9) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
