WormBase Tree Display for Gene: WBGene00016655
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WBGene00016655 | SMap | S_parent | Sequence | C44E4 | |||
---|---|---|---|---|---|---|---|
Identity | Version | 2 | |||||
Name | CGC_name | acbp-1 | Person_evidence | WBPerson344 | |||
Sequence_name | C44E4.6 | ||||||
Molecular_name | C44E4.6 | ||||||
C44E4.6.1 | |||||||
CE08720 | |||||||
C44E4.6.2 | |||||||
Other_name | CELE_C44E4.6 | Accession_evidence | NDB | BX284601 | |||
Public_name | acbp-1 | ||||||
DB_info | Database (10) | ||||||
Species | Caenorhabditis elegans | ||||||
History | Version_change (2) | ||||||
Status | Live | ||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | acbp | ||||||
Allele (28) | |||||||
Strain | WBStrain00033090 | ||||||
RNASeq_FPKM (74) | |||||||
GO_annotation | 00025731 | ||||||
00025732 | |||||||
00025733 | |||||||
00025734 | |||||||
00025735 | |||||||
00122228 | |||||||
Contained_in_operon | CEOP1196 | ||||||
Ortholog (36) | |||||||
Paralog | WBGene00001153 | Caenorhabditis elegans | From_analysis | Panther | |||
WormBase-Compara | |||||||
WBGene00007680 | Caenorhabditis elegans | From_analysis | Panther | ||||
WormBase-Compara | |||||||
WBGene00009818 | Caenorhabditis elegans | From_analysis | Panther | ||||
WormBase-Compara | |||||||
WBGene00012457 | Caenorhabditis elegans | From_analysis | Panther | ||||
WBGene00044603 | Caenorhabditis elegans | From_analysis | Panther | ||||
WBGene00018949 | Caenorhabditis elegans | From_analysis | Panther | ||||
WormBase-Compara | |||||||
Structured_description | Concise_description | acbp-1 encodes a highly conserved protein containing a functional acyl-CoA-binding binding domain orthologous to human DBI (Diazepam Binding inhibitor) (OMIM: 125950) required for protein stability and ligand binding; acyl-CoA proteins are required for lipid droplet morphology and lipid storage function; acbp-1 mutants have reduced triglycerides, aberrant lipid droplet morphology and number in the intestine; mutants contain approximately 70% fewer but 3.8 times enlarged than that of the average lipid droplet; loss of ACBP-1 results in increased lipid chain unsaturation by 1.25 times; disruption of ACBP-1 function significantly reduces worm life span from 14 to 9 days; ACBP-1::GFP is predominantly expressed in intestine of L4 larvae. | Paper_evidence | WBPaper00038378 | |||
Curator_confirmed | WBPerson12884 | ||||||
WBPerson1843 | |||||||
Date_last_updated | 16 May 2011 00:00:00 | ||||||
Automated_description | Predicted to enable long-chain fatty acyl-CoA binding activity. Involved in determination of adult lifespan and lipid storage. Is an ortholog of human DBI (diazepam binding inhibitor, acyl-CoA binding protein). | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Molecular_info | Corresponding_CDS | C44E4.6 | |||||
Corresponding_transcript | C44E4.6.1 | ||||||
C44E4.6.2 | |||||||
Other_sequence | GR14873 | ||||||
Tcir_isotig20858 | |||||||
Tcol_isotig21312 | |||||||
MH10887 | |||||||
JI472356.1 | |||||||
ASC17443_1 | |||||||
Dviv_isotig15304 | |||||||
Tcir_isotig10732 | |||||||
ES408833.1 | |||||||
Acan_isotig12435 | |||||||
Associated_feature | WBsf649109 | ||||||
WBsf649110 | |||||||
WBsf664159 | |||||||
WBsf219293 | |||||||
WBsf219294 | |||||||
Experimental_info | RNAi_result | WBRNAi00023965 | Inferred_automatically | RNAi_primary | |||
WBRNAi00023089 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00023677 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00042488 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00076215 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00023165 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00029810 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00001450 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00003156 | Inferred_automatically | RNAi_primary | |||||
Expr_pattern | Expr13616 | ||||||
Expr13619 | |||||||
Expr1016939 | |||||||
Expr1037161 | |||||||
Expr1146474 | |||||||
Expr2009114 | |||||||
Expr2027351 | |||||||
Drives_construct | WBCnstr00039882 | ||||||
Construct_product | WBCnstr00039882 | ||||||
Microarray_results (20) | |||||||
Expression_cluster (131) | |||||||
Interaction (40) | |||||||
Map_info | Map | I | Position | -1.03673 | Error | 0.000586 | |
Positive | Positive_clone | C44E4 | Inferred_automatically | From sequence, transcript, pseudogene data | |||
Pseudo_map_position | |||||||
Reference | WBPaper00027468 | ||||||
WBPaper00033353 | |||||||
WBPaper00038378 | |||||||
WBPaper00038491 | |||||||
WBPaper00039062 | |||||||
WBPaper00049828 | |||||||
WBPaper00055090 | |||||||
WBPaper00063976 | |||||||
Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||
Method | Gene |