WormBase Tree Display for Gene: WBGene00016204
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WBGene00016204 | SMap | S_parent | Sequence | C29E4 | |||||
---|---|---|---|---|---|---|---|---|---|
Identity | Version | 2 | |||||||
Name | CGC_name | gsto-1 | Paper_evidence | WBPaper00031042 | |||||
Sequence_name | C29E4.7 | ||||||||
Molecular_name | C29E4.7 | ||||||||
C29E4.7.1 | |||||||||
CE00089 | |||||||||
Other_name | CELE_C29E4.7 | Accession_evidence | NDB | BX284603 | |||||
Public_name | gsto-1 | ||||||||
DB_info | Database (12) | ||||||||
Species | Caenorhabditis elegans | ||||||||
History | Version_change | 1 | 28 May 2004 13:30:57 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of stlace from WS125 | ||
2 | 30 Oct 2007 09:47:18 | WBPerson2970 | Name_change | CGC_name | gsto-1 | ||||
Status | Live | ||||||||
Gene_info | Biotype | SO:0001217 | |||||||
Gene_class | gsto | ||||||||
Allele (25) | |||||||||
RNASeq_FPKM (74) | |||||||||
GO_annotation (30) | |||||||||
Ortholog (39) | |||||||||
Paralog | WBGene00001792 | Caenorhabditis elegans | From_analysis | TreeFam | |||||
Panther | |||||||||
WormBase-Compara | |||||||||
WBGene00015337 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
Panther | |||||||||
WormBase-Compara | |||||||||
WBGene00043097 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
Panther | |||||||||
WormBase-Compara | |||||||||
WBGene00019636 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
Panther | |||||||||
WormBase-Compara | |||||||||
WBGene00001365 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
WBGene00001371 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
WBGene00001790 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
WBGene00001791 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
WBGene00008920 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
WBGene00021817 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
Structured_description | Concise_description | gsto-1 encodes an experimentally verified thiol oxidoreductase and dehydroascorbate reductase, required for normal stress resistance; formally, GSTO-1 is an omega-class glutathione transferase (GST; EC 2.5.1.18), but it has little activity in vitro on classic GST substrates; GSTO-1 is expressed in postembryonic intestine; gsto-1(RNAi) induces hypersensitivity to heat-, arsenite-, juglone-, paraquat-, or cumene hydroperoxide-induced stresses, whereas overexpression of GSTO-1 enhances resistance to them; gsto-1 transcription is upregulated by stress; ELT-2 may directly activate gsto-1 transcription in developing gut via a 300-nucleotide sequence upstream of gsto-1's ATG start site. | Paper_evidence | WBPaper00031042 | |||||
WBPaper00031083 | |||||||||
Curator_confirmed | WBPerson567 | ||||||||
Date_last_updated | 16 Oct 2007 00:00:00 | ||||||||
Automated_description | Enables glutathione dehydrogenase (ascorbate) activity and glutathione transferase activity. Involved in cellular response to extracellular stimulus; obsolete oxidation-reduction process; and response to superoxide. Predicted to be located in cytoplasm. Human ortholog(s) of this gene implicated in Alzheimer's disease; Parkinson's disease; and asthma. Is an ortholog of human GSTO1 (glutathione S-transferase omega 1) and GSTO2 (glutathione S-transferase omega 2). | Paper_evidence | WBPaper00065943 | ||||||
Curator_confirmed | WBPerson324 | ||||||||
WBPerson37462 | |||||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
Disease_info | Potential_model | DOID:10652 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:13312,HGNC:23064) | ||||
DOID:2841 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:23064) | ||||||
DOID:14330 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:13312,HGNC:23064) | ||||||
Molecular_info | Corresponding_CDS | C29E4.7 | |||||||
Corresponding_transcript | C29E4.7.1 | ||||||||
Other_sequence | CBC14472_1 | ||||||||
AF203814.2 | |||||||||
CJC05775_1 | |||||||||
Associated_feature (3) | |||||||||
Experimental_info | RNAi_result (15) | ||||||||
Expr_pattern | Expr4883 | ||||||||
Expr4884 | |||||||||
Expr1021261 | |||||||||
Expr1036937 | |||||||||
Expr1145482 | |||||||||
Expr2012336 | |||||||||
Expr2030573 | |||||||||
Drives_construct | WBCnstr00012309 | ||||||||
WBCnstr00028246 | |||||||||
Construct_product | WBCnstr00012309 | ||||||||
WBCnstr00028246 | |||||||||
Antibody | WBAntibody00001308 | ||||||||
Microarray_results (18) | |||||||||
Expression_cluster (227) | |||||||||
Interaction (15) | |||||||||
Map_info (3) | |||||||||
Reference | WBPaper00024841 | ||||||||
WBPaper00031042 | |||||||||
WBPaper00038491 | |||||||||
WBPaper00042271 | |||||||||
WBPaper00045842 | |||||||||
WBPaper00055090 | |||||||||
Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
Method | Gene |