WormBase Tree Display for Gene: WBGene00010425
expand all nodes | collapse all nodes | view schema
WBGene00010425 | SMap | S_parent | Sequence | H37A05 | |||
---|---|---|---|---|---|---|---|
Identity | Version | 2 | |||||
Name | CGC_name | lpin-1 | Person_evidence | WBPerson8432 | |||
Sequence_name | H37A05.1 | ||||||
Molecular_name (3) | |||||||
Other_name | CELE_H37A05.1 | Accession_evidence | NDB | BX284605 | |||
Public_name | lpin-1 | ||||||
DB_info | Database | AceView | gene | 5O132 | |||
WormQTL | gene | WBGene00010425 | |||||
WormFlux | gene | WBGene00010425 | |||||
NDB | locus_tag | CELE_H37A05.1 | |||||
Panther | gene | CAEEL|WormBase=WBGene00010425|UniProtKB=Q9XXT5 | |||||
family | PTHR12181 | ||||||
NCBI | gene | 179853 | |||||
RefSeq | protein | NM_073979.7 | |||||
TREEFAM | TREEFAM_ID | TF314095 | |||||
TrEMBL | UniProtAcc | Q9XXT5 | |||||
UniProt_GCRP | UniProtAcc | Q9XXT5 | |||||
Species | Caenorhabditis elegans | ||||||
History | Version_change (2) | ||||||
Status | Live | ||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | lpin | ||||||
Allele (56) | |||||||
Strain | WBStrain00001552 | ||||||
WBStrain00029193 | |||||||
WBStrain00029194 | |||||||
WBStrain00037085 | |||||||
WBStrain00053909 | |||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (26) | |||||||
Ortholog (49) | |||||||
Structured_description | Concise_description | lpin-1 encodes a putative phosphatidic acid phosphatase orthologous tobudding yeast PAH1 and human LPIN1 (OMIM:605518), LPIN2 (OMIM:605519,mutated in Majeed syndrome), and LPIN3 (OMIM:605520); lpin-1 isexpressed in vulval muscle; in mass RNAi assays, lpin-1 is requiredfor the osmotic integrity of eggs and for normal larval growth, bodythickness, locomotion, and fertility; by orthology, LPIN-1 is expectedto be dephosphorylated by SCPL-2. | Paper_evidence | WBPaper00005654 | |||
WBPaper00006525 | |||||||
WBPaper00024497 | |||||||
WBPaper00025054 | |||||||
WBPaper00029274 | |||||||
WBPaper00029281 | |||||||
WBPaper00029282 | |||||||
WBPaper00029283 | |||||||
WBPaper00029284 | |||||||
Curator_confirmed | WBPerson1843 | ||||||
WBPerson567 | |||||||
Date_last_updated | 17 Jun 2009 00:00:00 | ||||||
Automated_description | Predicted to enable phosphatidate phosphatase activity and transcription coactivator activity. Involved in several processes, including endomembrane system organization; macromolecule localization; and nematode larval development. Located in endoplasmic reticulum; nuclear envelope; and nucleoplasm. Expressed in head neurons and hypodermis. Used to study obesity. Human ortholog(s) of this gene implicated in morbid obesity. Is an ortholog of human LPIN2 (lipin 2). | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Disease_info | Experimental_model | DOID:9970 | Homo sapiens | Paper_evidence | WBPaper00033438 | ||
Curator_confirmed | WBPerson38202 | ||||||
Date_last_updated | 11 Jun 2018 00:00:00 | ||||||
Potential_model | DOID:11981 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:13345) | |||
Models_disease_asserted | WBDOannot00000542 | ||||||
Molecular_info | Corresponding_CDS | H37A05.1 | |||||
Corresponding_CDS_history | H37A05.1:wp229 | ||||||
Corresponding_transcript | H37A05.1.1 | ||||||
Other_sequence (51) | |||||||
Associated_feature (20) | |||||||
Experimental_info | RNAi_result (65) | ||||||
Expr_pattern | Chronogram1159 | ||||||
Expr6290 | |||||||
Expr8650 | |||||||
Expr8695 | |||||||
Expr11676 | |||||||
Expr1026973 | |||||||
Expr1034547 | |||||||
Expr1153265 | |||||||
Expr2013257 | |||||||
Expr2031488 | |||||||
Drives_construct | WBCnstr00002394 | ||||||
WBCnstr00013464 | |||||||
WBCnstr00015871 | |||||||
WBCnstr00015872 | |||||||
Construct_product | WBCnstr00013464 | ||||||
WBCnstr00015871 | |||||||
WBCnstr00019172 | |||||||
Antibody (5) | |||||||
Microarray_results (22) | |||||||
Expression_cluster (127) | |||||||
Interaction (15) | |||||||
Map_info | Map | V | Position | 5.54896 | Error | 0.007081 | |
Positive | Positive_clone | H37A05 | Inferred_automatically | From sequence, transcript, pseudogene data | |||
Pseudo_map_position | |||||||
Reference (12) | |||||||
Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||
Method | Gene |