WormBase Tree Display for Gene: WBGene00007772
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| WBGene00007772 | SMap | S_parent | Sequence | C27C12 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | egrh-1 | Person_evidence | WBPerson460 | |||||
| Sequence_name | C27C12.2 | ||||||||
| Molecular_name | C27C12.2 | ||||||||
| C27C12.2.1 | |||||||||
| CE40601 | |||||||||
| Other_name | CELE_C27C12.2 | Accession_evidence | NDB | BX284606 | |||||
| Public_name | egrh-1 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 26 May 2004 16:54:48 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of WS125 | ||
| 2 | 26 Mar 2007 13:57:19 | WBPerson2970 | Name_change | CGC_name | egrh-1 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | egrh | ||||||||
| Allele (58) | |||||||||
| Strain | WBStrain00029951 | ||||||||
| WBStrain00051977 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (13) | |||||||||
| Ortholog (36) | |||||||||
| Paralog (7) | |||||||||
| Structured_description | Concise_description | egrh-1 encodes a zinc finger protein that has similarity to the vertebrate EGR (early growth response factor) family of proteins, including the human EGR transcription factors; in C. elegans, EGRH-1 activity is required, non-autonomously in the gut and the somatic gonad, for regulation of oocyte meiotic maturation and ovulation; EGRH-1 is expressed in the somatic gonad, specifically in the gonadal sheath and distal tip cells, and in sperm, as well as in the gut, and other non-gonadal tissues. | Paper_evidence | WBPaper00037082 | |||||
| Curator_confirmed | WBPerson12884 | ||||||||
| WBPerson1843 | |||||||||
| WBPerson1823 | |||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 12 Jan 2015 00:00:00 | ||||||||
| Automated_description | Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in negative regulation of oocyte maturation and negative regulation of ovulation. Located in nucleus and perinuclear region of cytoplasm. Expressed in body wall musculature; hermaphrodite somatic gonadal cell; nervous system; pharynx; and sperm. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; artery disease (multiple); lung disease (multiple); and neuropathy (multiple). Is an ortholog of human EGR1 (early growth response 1) and EGR3 (early growth response 3). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model (19) | ||||||||
| Molecular_info | Corresponding_CDS | C27C12.2 | |||||||
| Corresponding_transcript | C27C12.2.1 | ||||||||
| Other_sequence (22) | |||||||||
| Associated_feature (14) | |||||||||
| Transcription_factor | WBTranscriptionFactor000963 | ||||||||
| Experimental_info | RNAi_result | WBRNAi00092959 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00029263 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00110186 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00076168 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00041323 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00110187 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00110188 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00011248 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00114391 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00070166 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr9107 | ||||||||
| Expr1017133 | |||||||||
| Expr1033368 | |||||||||
| Expr1145368 | |||||||||
| Expr2011234 | |||||||||
| Expr2029470 | |||||||||
| Drives_construct | WBCnstr00008304 | ||||||||
| WBCnstr00008305 | |||||||||
| Construct_product | WBCnstr00008304 | ||||||||
| Antibody | WBAntibody00002152 | ||||||||
| Microarray_results (20) | |||||||||
| Expression_cluster (136) | |||||||||
| Interaction (21) | |||||||||
| Anatomy_function | WBbtf0409 | ||||||||
| WBbtf0410 | |||||||||
| WBbtf0411 | |||||||||
| WBbtf1061 | |||||||||
| Map_info (3) | |||||||||
| Reference | WBPaper00027882 | ||||||||
| WBPaper00032994 | |||||||||
| WBPaper00037082 | |||||||||
| WBPaper00038491 | |||||||||
| WBPaper00055090 | |||||||||
| WBPaper00061738 | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
