WormBase Tree Display for Gene: WBGene00004303
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WBGene00004303 | SMap | S_parent | Sequence | C29E4 | ||
---|---|---|---|---|---|---|
Identity | Version | 2 | ||||
Name | CGC_name | ran-2 | ||||
Sequence_name | C29E4.3 | |||||
Molecular_name | C29E4.3a | |||||
C29E4.3a.1 | ||||||
CE37483 | ||||||
C29E4.3b | ||||||
CE30621 | ||||||
C29E4.3b.1 | ||||||
C29E4.3b.2 | ||||||
Other_name (2) | ||||||
Public_name | ran-2 | |||||
DB_info | Database | AceView | gene | 3J25 | ||
WormQTL | gene | WBGene00004303 | ||||
WormFlux | gene | WBGene00004303 | ||||
NDB | locus_tag | CELE_C29E4.3 | ||||
Panther | gene | CAEEL|WormBase=WBGene00004303|UniProtKB=P34342 | ||||
family | PTHR24113 | |||||
NCBI | gene | 176115 | ||||
RefSeq | protein | NM_171884.5 | ||||
NM_171198.8 | ||||||
SwissProt | UniProtAcc | P34342 | ||||
TREEFAM | TREEFAM_ID | TF318283 | ||||
UniProt_GCRP | UniProtAcc | P34342 | ||||
Species | Caenorhabditis elegans | |||||
History | Version_change (2) | |||||
Acquires_merge | WBGene00004067 | |||||
Status | Live | |||||
Gene_info | Biotype | SO:0001217 | ||||
Gene_class | ran | |||||
Allele (51) | ||||||
Legacy_information | [Schnabel H] maternal effect embryonic lethal with abnormal pronuclear apppearance | |||||
Strain | WBStrain00036599 | |||||
WBStrain00007779 | ||||||
WBStrain00054780 | ||||||
RNASeq_FPKM (74) | ||||||
GO_annotation (13) | ||||||
Contained_in_operon | CEOP3465 | |||||
Ortholog (47) | ||||||
Structured_description | Concise_description | ran-2 encodes the C. elegans RanGAP (GTPase activating protein) homolog, conserved amongst yeast, Drosophila (segregation distorter), Xenopus, and humans; by homology, RAN-2 is predicted to function as a key regulator of the Ran GTP/GDP cycle by stimulating the otherwise weak Ran GTPase activity; in C. elegans, RAN-2 activity is essential during early embryogenesis for comigration of centrosomes with the male pronucleus, mitotic spindle formation, chromosome segregation, and nuclear envelope assembly; in addition, RAN-2 is also required for nucleocytoplasmic transport; ran-2 reporter gene expression is detected in embryos and larvae. | Paper_evidence | WBPaper00004403 | ||
WBPaper00004651 | ||||||
WBPaper00005178 | ||||||
WBPaper00005637 | ||||||
WBPaper00011686 | ||||||
Curator_confirmed | WBPerson1843 | |||||
Date_last_updated | 17 Jun 2004 00:00:00 | |||||
Automated_description | Predicted to enable GTPase activator activity and small GTPase binding activity. Involved in embryo development. Predicted to be located in cytosol; nucleus; and perinuclear region of cytoplasm. Expressed in intestinal cell. Is an ortholog of human RANGAP1 (Ran GTPase activating protein 1). | Paper_evidence | WBPaper00065943 | |||
Curator_confirmed | WBPerson324 | |||||
WBPerson37462 | ||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | |||||
Date_last_updated | 29 Nov 2023 00:00:00 | |||||
Molecular_info | Corresponding_CDS | C29E4.3a | ||||
C29E4.3b | ||||||
Corresponding_CDS_history | C29E4.3a:wp130 | |||||
Corresponding_transcript | C29E4.3a.1 | |||||
C29E4.3b.1 | ||||||
C29E4.3b.2 | ||||||
Other_sequence (24) | ||||||
Associated_feature | WBsf645370 | |||||
WBsf645371 | ||||||
WBsf976236 | ||||||
WBsf976237 | ||||||
WBsf225302 | ||||||
WBsf225303 | ||||||
WBsf225304 | ||||||
WBsf225305 | ||||||
Experimental_info | RNAi_result | WBRNAi00085739 | Inferred_automatically | RNAi_primary | ||
WBRNAi00062934 | Inferred_automatically | RNAi_primary | ||||
WBRNAi00062949 | Inferred_automatically | RNAi_primary | ||||
WBRNAi00001007 | Inferred_automatically | RNAi_primary | ||||
WBRNAi00041448 | Inferred_automatically | RNAi_primary | ||||
WBRNAi00086891 | Inferred_automatically | RNAi_primary | ||||
WBRNAi00062955 | Inferred_automatically | RNAi_primary | ||||
WBRNAi00002456 | Inferred_automatically | RNAi_primary | ||||
WBRNAi00062942 | Inferred_automatically | RNAi_primary | ||||
WBRNAi00065354 | Inferred_automatically | RNAi_primary | ||||
Expr_pattern | Expr2038 | |||||
Expr1026981 | ||||||
Expr1032128 | ||||||
Expr1145479 | ||||||
Expr2015251 | ||||||
Expr2033485 | ||||||
Microarray_results (20) | ||||||
Expression_cluster (122) | ||||||
Interaction (111) | ||||||
Map_info (3) | ||||||
Reference (11) | ||||||
Remark | Sequence connection from [Askjaer P, Mattaj IW]. krb 13/11/01 | |||||
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||
Method | Gene |